Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow HAX1 rightarrow Monoclonal HAX1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Heat Shock Protein 40, HSP-40 ELISA Kit
 • Collagen Type lV (COL4) ELISA Kit
 • PSME1 Antibody
 • CD18 Antibody
 • CD48 Antibody
 • protein tyrosine phosphatase, receptor type, S (PTPRS) Antibody
 • CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Antibody
 • Alpha-Fetoprotein L3 (AFP-L3) ELISA Kit
 • Complement Component 5a (C5a) ELISA Kit
 • Killer Cell Immunoglobulin Like Receptor 2DS2 (KIR2DS2) Recombinant Protein
 • SRPRB Antibody
 • HOOK2 Antibody
 • Adenovirus Hexon Antibody
 • Influenza virus (H3N2) Antigen
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-HAX1 antibody :: Mouse anti-Human HAX1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200151
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HAX1, Monoclonal Antibody

 Also Known As   

HAX1 antibody

 Product Synonym Names    HCLS1 associated protein X-1; HS1BP1; HCLSBP1; HCLS1 (and PKD2) associated protein
 Product Gene Name   

anti-HAX1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    U68566 mRNA
 3D Structure    ModBase 3D Structure for O00165
Section Bar
 Clonality    Monoclonal
 Isotype    IgG2b, k
 Clone Number    AT3C5
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
Section Bar
 Antigen Species    Human
 Immunogen    Recombinant human HAX1 (1-279aa) purified from E. coli
 Clone Note    Anti-human HAX1 mAb, clone AT3C5, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human HAX1 protein.
Section Bar
 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-HAX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-HAX1 antibody

   HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1 (HS1), one of the substrates of receptor-coupled tyrosine kinases activated during clonal expansion and deletion in lymphoid cells. It also interacts with the product of the polycystic kidney disease 2 (PKD2) gene and with the F-actin-binding protein, cortactin. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.
 Product Categories/Family for anti-HAX1 antibody    Metabolism
 Applications Tested/Suitable for anti-HAX1 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)

 Application Notes for anti-HAX1 antibody    WB: 1:1000 ~ 2000.
Recommended starting dilution is 1:1000.
Section Bar
 Western Blot (WB) of anti-HAX1 antibody    The HeLa cell lysate (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human HAX1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. The Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human HAX1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Raji cell lysate
anti-HAX1 antibody Western Blot (WB) (WB) image
Section Bar
 Immunofluorescence (IF) of anti-HAX1 antibody    ICC/IF analysis of HAX1 in HeLa cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human HAX1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
anti-HAX1 antibody Immunofluorescence (IF) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for HAX1. It may not necessarily be applicable to this product.
 NCBI GI #    13435356
 NCBI GeneID    10456
 NCBI Accession #    NP_006109 [Other Products]
 NCBI GenBank Nucleotide #    NM_006118.3 [Other Products]
Section Bar
 UniProt Primary Accession #    O00165 [Other Products]
 UniProt Secondary Accession #    Q5VYD5; Q5VYD7; Q96AU4; Q9BS80; A8W4W9; A8W4X0; B4DUJ7 [Other Products]
 UniProt Related Accession #    O00165 [Other Products]
 Molecular Weight    21,801 Da
Table BarTOPTable Bar
 NCBI Official Full Name    HCLS1-associated protein X-1 isoform a
 NCBI Official Synonym Full Names    HCLS1 associated protein X-1
 NCBI Official Symbol    HAX1 [Similar Products]
 NCBI Official Synonym Symbols   
SCN3; HS1BP1; HCLSBP1
[Similar Products]
 NCBI Protein Information    HCLS1-associated protein X-1
 UniProt Protein Name    HCLS1-associated protein X-1
 UniProt Synonym Protein Names   
HS1-associating protein X-1; HAX-1; HS1-binding protein 1; HSP1BP-1
 Protein Family    HCLS1-associated protein
 UniProt Gene Name    HAX1 [Similar Products]
 UniProt Synonym Gene Names    HS1BP1; HAX-1; HSP1BP-1 [Similar Products]
Section Bar
 NCBI Summary for HAX1    The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for HAX1    Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
Table BarTOPTable Bar
 

Product References and Citations for anti-HAX1 antibody

   Klein C, et al., (2007) Nat Genet. 39 (1):86-92; Yin H, et al., (2001) Cytokine. 15 (3):122-37
Section Bar
 Research Articles on HAX1    1. Oncogenic HAX-1 increases the proliferation, migration, and angiogenic activity of HUVECs. Findings provide unique insight into the pathogenesis of NPC.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-HAX1 antibodyDiseases associated with anti-HAX1 antibody
 Reference Product  PubMed Publications
 G6PC3 antibody  >15 publications with HAX1 and G6PC3
 HCLS1 antibody  >14 publications with HAX1 and HCLS1
 HTRA2 antibody  >6 publications with HAX1 and HTRA2
 PARL antibody  >3 publications with HAX1 and PARL
 CTTN antibody  >3 publications with HAX1 and CTTN
 PKD2 antibody  >2 publications with HAX1 and PKD2
 Disease Name  Pubmed Publications
 Neutropenia, Severe Congenital, Autosomal Recessive 3 Antibodies  >29 publications with HAX1 and Neutropenia, Severe Congenital, Autosomal Recessive 3
 Cell Transformation, Neoplastic Antibodies  >11 publications with HAX1 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >8 publications with HAX1 and Neoplasm Metastasis
 Heart Diseases Antibodies  >6 publications with HAX1 and Heart Diseases
 Disease Models, Animal Antibodies  >4 publications with HAX1 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >3 publications with HAX1 and Neurobehavioral Manifestations
 Liver Diseases Antibodies  >2 publications with HAX1 and Liver Diseases
 Neurodegenerative Diseases Antibodies  >2 publications with HAX1 and Neurodegenerative Diseases
 Atrophy Antibodies  >2 publications with HAX1 and Atrophy
 Necrosis Antibodies  >2 publications with HAX1 and Necrosis
Organs/Tissues associated with anti-HAX1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >51 publications with HAX1 and Blood
 Bone Antibodies  >27 publications with HAX1 and Bone
 Bone Marrow Antibodies  >27 publications with HAX1 and Bone Marrow
 Muscle Antibodies  >13 publications with HAX1 and Muscle
 Heart Antibodies  >12 publications with HAX1 and Heart
 Skin Antibodies  >10 publications with HAX1 and Skin
 Brain Antibodies  >9 publications with HAX1 and Brain
 Liver Antibodies  >7 publications with HAX1 and Liver
 Lymph Node Antibodies  >6 publications with HAX1 and Lymph Node
 Lymph Antibodies  >6 publications with HAX1 and Lymph
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions