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| Product Name
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HCN1 Cyclic nucleotide-gated Channel, Monoclonal Antibody
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| Also Known As
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Anti-HCN1 Cyclic Nucleotide-Gated Channel Monoclonal Antibody
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Immunogen Sequence Positions
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778-910
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| Clonality
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Monoclonal
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| Isotype
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lgG1
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| Clone Number
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S70-28
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| Host
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Mouse
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| Species Reactivity
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Human, mouse, rat
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| Specificity
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HCN1 Cyclic nucleotide-gated Channel
This antibody recognizes human, mouse, and rat HCN1. It does not cross-react with HCN2.
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| Form/Format
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100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography
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| Antigen
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Fusion protein aa 778-910 (C-terminus) of rat HCN! (accession number Q9JKBO).
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| Dilution Instructions
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Dilute in PBS or medium which is identical to that used in the assay system.
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| Preparation and Storage
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This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
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| Other Notes
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Small volumes of anti-hcn1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulation of cell excitability. They contribute to spontaneous rhythmic activity in the heart and brain.
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| Applications Tested/Suitable for anti-hcn1 antibody
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Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence
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| Application Notes for anti-hcn1 antibody
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Immunoblotting: use at 1-10ug/ml. A band of ~100kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1 ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate
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TOP
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| NCBI/Uniprot data below describe general gene information for hcn1. It may not necessarily be applicable to this product. |
| NCBI GI #
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185136002
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| NCBI GeneID
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100135980
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| NCBI Accession #
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NP_001117790.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001124318.1
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[Other Products]
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TOP
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| NCBI Official Full Name
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hyperpolarization-activated cyclic nucleotide-gated cation channel 1
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| NCBI Official Symbol
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hcn1
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[Similar Products]
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| NCBI Protein Information
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hyperpolarization-activated cyclic nucleotide-gated cation channel 1
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| Protein Family
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Anaphase-promoting complex
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Organs/Tissues associated with anti-hcn1 antibody |
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TOP
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Antibody 
