NP_067690.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
NCBI Official Synonym Full Names
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
NCBI Protein Information
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; hyperpolarization-activated, cyclic nucleotide-gated K+ 4
UniProt Protein Name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
UniProt Entry Name
HCN4_RAT
NCBI Summary for Hcn4
may act as a neuronal pacemaker channel; may play a role in neurotransmitter release [RGD, Feb 2006]
UniProt Comments for Hcn4
HCN4: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli. Defects in HCN4 are a cause of sick sinus syndrome type 2 (SSS2); also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors, in which case it is considered to be a congenital disorder. Defects in HCN4 are the cause of Brugada syndrome type 8 (BRGDA8). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the potassium channel HCN family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation
Cellular Component: neuron projection; cell soma; basolateral plasma membrane; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; terminal button; intrinsic to plasma membrane
Molecular Function: identical protein binding; protein binding; voltage-gated potassium channel activity; potassium channel activity; intracellular cAMP activated cation channel activity; voltage-gated sodium channel activity; cAMP binding
Biological Process: regulation of synaptic transmission; regulation of membrane potential; regulation of heart rate; in utero embryonic development; regulation of heart contraction; cation transport
Product References and Citations for anti-Hcn4 antibody
1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.:Sunderland, MA USA. 2. www.iochannels.org 3. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34232
Research Articles on Hcn4
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Products associated with anti-Hcn4 antibody
Pathways associated with anti-Hcn4 antibody
Diseases associated with anti-Hcn4 antibody
Organs/Tissues associated with anti-Hcn4 antibody
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