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anti-HDAC10 antibody :: Mouse anti-Human HDAC10 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS830442
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HDAC10, Monoclonal Antibody

 Also Known As   

HDAC10 antibody

 Product Synonym Names    Monoclonal HDAC10; Anti-HDAC10; HDA-1c0; HDA 1c0; Histone Deacetylase 10; HDAC10
 Product Gene Name   

anti-HDAC10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608544
 3D Structure    ModBase 3D Structure for Q969S8
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1B1
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    HDAC10 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    A class II histone deacetylase, HDAC10 is most similar to HDAC6. Both contain a unique, putative second catalytic domain not found in other HDACs. In HDAC10, however, this domain is not functional. HDAC10 resides in both the nucleus and cytoplasm.
 Immunogen    HDAC10 antibody was raised in mouse using a full length recombinant protein of human HDAC10 (NP_114408) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-HDAC10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HDAC10 antibody

   Mouse monoclonal HDAC10 antibody
 Product Categories/Family for anti-HDAC10 antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-HDAC10 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-HDAC10 antibody    FC: 1:100
IF: 1:100
WB: 1:2000
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 Western Blot (WB) of anti-HDAC10 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant HDAC10 protein (Right) or empty vector (Left) detected with HDAC10 antibody
anti-HDAC10 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-HDAC10 antibody    Immunofluorescent staining of COS7 cells transiently transfected with recombinant HDAC10 protein using HDAC10 antibody
anti-HDAC10 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for HDAC10. It may not necessarily be applicable to this product.
 NCBI GI #    20070354
 NCBI GeneID    83933
 NCBI Accession #    NP_114408 [Other Products]
 NCBI GenBank Nucleotide #    NM_032019.5 [Other Products]
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 UniProt Primary Accession #    Q969S8 [Other Products]
 UniProt Secondary Accession #    Q08AP4; Q6STF9; Q96P77; Q96P78; Q9H028; Q9UGX1; Q9UGX2 [Other Products]
 UniProt Related Accession #    Q969S8 [Other Products]
 Molecular Weight    43,016 Da
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 NCBI Official Full Name    histone deacetylase 10 isoform 1
 NCBI Official Synonym Full Names    histone deacetylase 10
 NCBI Official Symbol    HDAC10 [Similar Products]
 NCBI Official Synonym Symbols   
HD10
[Similar Products]
 NCBI Protein Information    histone deacetylase 10
 UniProt Protein Name    Histone deacetylase 10
 Protein Family    Histone deacetylase
 UniProt Gene Name    HDAC10 [Similar Products]
 UniProt Synonym Gene Names    HD10 [Similar Products]
 UniProt Entry Name    HDA10_HUMAN
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 NCBI Summary for HDAC10    The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for HDAC10    HDAC10: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Belongs to the histone deacetylase family. HD type 2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; EC 3.5.1.98; Deacetylase

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: nucleoplasm; cytoplasm; histone deacetylase complex; nucleus

Molecular Function: NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity

Biological Process: establishment and/or maintenance of chromatin architecture; Notch signaling pathway; protein amino acid deacetylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; histone deacetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; oligodendrocyte development; negative regulation of transcription, DNA-dependent
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 Research Articles on HDAC10    1. Suggest HDAC10 expression as a prognostic marker for gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HDAC10 antibodyPathways associated with anti-HDAC10 antibody
 Reference Product  PubMed Publications
 HDAC3 antibody  >13 publications with HDAC10 and HDAC3
 HDAC1 antibody  >11 publications with HDAC10 and HDAC1
 HDAC2 antibody  >10 publications with HDAC10 and HDAC2
 HDAC8 antibody  >7 publications with HDAC10 and HDAC8
 EP300 antibody  >1 publications with HDAC10 and EP300
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 HDACs Deacetylate Histones Pathway antibodies  HDACs Deacetylate Histones Pathway Diagram
 NOTCH1 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH1 Intracellular Domain Regulates Transcription Pathway Diagram
Diseases associated with anti-HDAC10 antibodyOrgans/Tissues associated with anti-HDAC10 antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >3 publications with HDAC10 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with HDAC10 and Carcinoma, Hepatocellular
 Immune System Diseases Antibodies  >2 publications with HDAC10 and Immune System Diseases
 Liver Neoplasms Antibodies  >2 publications with HDAC10 and Liver Neoplasms
 Adenoma Antibodies  >1 publications with HDAC10 and Adenoma
 Seizures Antibodies  >1 publications with HDAC10 and Seizures
 Inflammation Antibodies  >1 publications with HDAC10 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with HDAC10 and Blood
 Lung Antibodies  >4 publications with HDAC10 and Lung
 Brain Antibodies  >4 publications with HDAC10 and Brain
 Stomach Antibodies  >3 publications with HDAC10 and Stomach
 Lymph Node Antibodies  >2 publications with HDAC10 and Lymph Node
 Lymph Antibodies  >2 publications with HDAC10 and Lymph
 Bone Antibodies  >2 publications with HDAC10 and Bone
 Liver Antibodies  >2 publications with HDAC10 and Liver
 Kidney Antibodies  >1 publications with HDAC10 and Kidney
 Embryonic Tissue Antibodies  >1 publications with HDAC10 and Embryonic Tissue
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