NP_006092.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,913 Da
NCBI Official Full Name
kinetochore protein NDC80 homolog
NCBI Official Synonym Full Names
NDC80 kinetochore complex component
NCBI Official Synonym Symbols
HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80 [Similar Products]
NCBI Protein Information
kinetochore protein NDC80 homolog; kinetochore associated 2; kinetochore protein Hec1; kinetochore-associated protein 2; highly expressed in cancer protein; retinoblastoma-associated protein HEC; NDC80 kinetochore complex component homolog; NDC80 homolog, kinetochore complex component; highly expressed in cancer, rich in leucine heptad repeats
UniProt Protein Name
Kinetochore protein NDC80 homolog
UniProt Synonym Protein Names
Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC
UniProt Synonym Gene Names
UniProt Entry Name
NDC80_HUMAN
NCBI Summary for HEC1
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
UniProt Comments for HEC1
HEC1: plays an essential role in chromosome segregation by interacting through its coiled-coil domains with several proteins that modulate the G2/M phase. Phosphorylation by Nek2 is essential for faithful chromosome segregation. Required for the recruitment of Mps1 kinase and Mad1/Mad2 complexes to kinetochores.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 18p11.32
Cellular Component: kinetochore; membrane; nucleus; cytosol; chromosome, pericentric region
Molecular Function: protein binding; structural constituent of cytoskeleton
Biological Process: mitosis; mitotic spindle organization and biogenesis; establishment of mitotic spindle orientation; attachment of spindle microtubules to kinetochore during mitosis; mitotic sister chromatid segregation; cell division; mitotic cell cycle; attachment of spindle microtubules to kinetochore; chromosome segregation
Research Articles on HEC1
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Products associated with anti-HEC1 antibody
Pathways associated with anti-HEC1 antibody
Diseases associated with anti-HEC1 antibody
Organs/Tissues associated with anti-HEC1 antibody
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