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anti-HGF antibody :: Mouse anti-Human HGF HGF Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS530424 anti-HGF antibody
Unit / Price
0.5 mg  /  $1,445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HGF, Monoclonal Antibody

 Also Known As   

HGF antibody

 Product Synonym Names    Monoclonal HGF; Anti-HGF; Scatter Factor; Hepatocyte Growth Factor; HPTA; SF; Hepatopoietin
 Product Gene Name   

anti-HGF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142409
 3D Structure    ModBase 3D Structure for P14210
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    M952901
 Host    Mouse
 Species Reactivity    Human HGF
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 Form/Format    Supplied as a lyophilized powder.
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 Biological Significance    HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an Nterminal PAN/APPLE like domain, four Kringle domains, and a serine proteinaselike domain that has no detectable protease activity (1 5). Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide.
 Endotoxin Levels    <0.1 EU per 1 ug of the antibody by the LAL method.
 Immunogen    HGF antibody was raised in mouse using S. frugiperda insect ovarian cell line Sf 21-derived recombinant human HGF as the immunogen.
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 Preparation and Storage    Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-HGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HGF antibody

   Mouse monoclonal HGF antibody
 Product Categories/Family for anti-HGF antibody    Cytokines & Growth Factors
 Applications Tested/Suitable for anti-HGF antibody   

Neutralization, Western Blot (WB)

 Application Notes for anti-HGF antibody    Neutralization: 0.1-0.3 ug/ml
WB: 1 ug/ml
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NCBI/Uniprot data below describe general gene information for HGF. It may not necessarily be applicable to this product.
 NCBI GI #    337938
 NCBI GeneID    3082
 NCBI Accession #    AAA64297.1 [Other Products]
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 UniProt Primary Accession #    P14210 [Other Products]
 UniProt Secondary Accession #    Q02935; Q13494; Q14519; Q3KRB2; Q8TCE2; Q9BYL9; Q9BYM0; Q9UDU6; A1L3U6 [Other Products]
 UniProt Related Accession #    P14210 [Other Products]
 Molecular Weight    24,116 Da
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 NCBI Official Full Name    hepatocyte growth factor
 NCBI Official Synonym Full Names    hepatocyte growth factor (hepapoietin A; scatter factor)
 NCBI Official Symbol    HGF [Similar Products]
 NCBI Official Synonym Symbols   
SF; HGFB; HPTA; F-TCF; DFNB39
[Similar Products]
 NCBI Protein Information    hepatocyte growth factor
 UniProt Protein Name    Hepatocyte growth factor
 UniProt Synonym Protein Names   
Hepatopoietin-A; Scatter factor; SF
 Protein Family    Hepatocyte growth factor
 UniProt Gene Name    HGF [Similar Products]
 UniProt Synonym Gene Names    HPTA; SF [Similar Products]
 UniProt Entry Name    HGF_HUMAN
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 NCBI Summary for HGF    Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HGF    HGF: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization. Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39). A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the peptidase S1 family. Plasminogen subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Hormone; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q21.1

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; serine-type endopeptidase activity; chemoattractant activity

Biological Process: positive regulation of myelination; mitosis; platelet activation; organ regeneration; activation of MAPK activity; myoblast proliferation; hepatocyte growth factor receptor signaling pathway; negative regulation of caspase activity; proteolysis; liver development; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; platelet degranulation; positive chemotaxis; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; hyaluronan metabolic process; positive regulation of cell migration

Disease: Deafness, Autosomal Recessive 39
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 Research Articles on HGF    1. This SOCS7 knockdown-attributed effect could be due to a precise anti-PLCg-1 role.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HGF antibodyDiseases associated with anti-HGF antibody
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >776 publications with HGF and Liver Diseases
 Vascular Diseases Antibodies  >621 publications with HGF and Vascular Diseases
 Cardiovascular Diseases Antibodies  >611 publications with HGF and Cardiovascular Diseases
 Necrosis Antibodies  >472 publications with HGF and Necrosis
 Fibrosis Antibodies  >458 publications with HGF and Fibrosis
 Inflammation Antibodies  >441 publications with HGF and Inflammation
 Liver Neoplasms Antibodies  >439 publications with HGF and Liver Neoplasms
 Neoplasm Invasiveness Antibodies  >435 publications with HGF and Neoplasm Invasiveness
 Neoplasms, Experimental Antibodies  >311 publications with HGF and Neoplasms, Experimental
 Kidney Diseases Antibodies  >306 publications with HGF and Kidney Diseases
Organs/Tissues associated with anti-HGF antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1874 publications with HGF and Blood
 Liver Antibodies  >1713 publications with HGF and Liver
 Vascular Antibodies  >1283 publications with HGF and Vascular
 Bone Antibodies  >780 publications with HGF and Bone
 Kidney Antibodies  >763 publications with HGF and Kidney
 Lung Antibodies  >718 publications with HGF and Lung
 Muscle Antibodies  >627 publications with HGF and Muscle
 Bone Marrow Antibodies  >539 publications with HGF and Bone Marrow
 Embryonic Tissue Antibodies  >381 publications with HGF and Embryonic Tissue
 Brain Antibodies  >362 publications with HGF and Brain
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