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anti-HIP2 antibody :: Mouse anti-Human HIP2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120186
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HIP2, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human HIP2

 Product Synonym Names    Homo sapiens huntingtin interacting protein 2 (HIP2); LIG;HYPG; UBE2K
 Product Gene Name   

anti-HIP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602846
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    757C3a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-HIP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HIP2 antibody

   The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-HIP2 antibody   

Dot Blot (DB)

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 Quality Control of anti-HIP2 antibody    Western blot analysis of immunized recombinant protein, using anti-HIP2 monoclonal antibody.
anti-HIP2 antibody Quality Control image
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 Quality Control #2 of anti-HIP2 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-HIP2 antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for HIP2. It may not necessarily be applicable to this product.
 NCBI GI #    163660383
 NCBI GeneID    3093
 NCBI Accession #    NP_005330.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005339 [Other Products]
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 UniProt Secondary Accession #    O54806; P27924; Q16721; Q9CVV9; Q9Y2D3; A6NJC1; A8K5Y9; B2RDF8; C9JGP1 [Other Products]
 UniProt Related Accession #    P61086 [Other Products]
 Molecular Weight    17,447 Da
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 NCBI Official Full Name    Homo sapiens ubiquitin-conjugating enzyme E2K (UBE2K), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    ubiquitin-conjugating enzyme E2K
 NCBI Official Symbol    UBE2K [Similar Products]
 NCBI Official Synonym Symbols   
LIG; HIP2; HYPG; UBC1; E2-25K
[Similar Products]
 NCBI Protein Information    ubiquitin-conjugating enzyme E2 K; E2(25K); HIP-2; huntingtin interacting protein 2; huntingtin-interacting protein 2; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 KDA; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-protein ligase
 Protein Family    High-potential iron-sulfur protein
 UniProt Gene Name    UBE2K [Similar Products]
 UniProt Entry Name    UBE2K_HUMAN
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 NCBI Summary for HIP2    The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HIP2    UBE2K: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein- dependent degradation of RB1. Interacts with RNF138/NARF. Interacts with BRCA1. By aggregated low-density lipoprotein. Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19

Cellular Component: filopodium tip; intermediate filament cytoskeleton; cytoplasm; nucleus; actin cytoskeleton

Molecular Function: small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; nucleotide binding; ATP binding; ligase activity

Biological Process: protein polyubiquitination; regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination
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 Research Articles on HIP2    1. Hip2, a ubiquitin-conjugating enzyme, can overcome radiation-induced G2/M cell cycle arrest and trigger the entry into mitosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HIP2 antibodyDiseases associated with anti-HIP2 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
 RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways antibodies  RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >8 publications with HIP2 and Brain Diseases
 Cognition Disorders Antibodies  >3 publications with HIP2 and Cognition Disorders
 Cardiovascular Diseases Antibodies  >1 publications with HIP2 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1 publications with HIP2 and Atherosclerosis
 Vascular Diseases Antibodies  >1 publications with HIP2 and Vascular Diseases
 Weight Loss Antibodies  >1 publications with HIP2 and Weight Loss
Organs/Tissues associated with anti-HIP2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with HIP2 and Brain
 Nerve Antibodies  >5 publications with HIP2 and Nerve
 Blood Antibodies  >4 publications with HIP2 and Blood
 Liver Antibodies  >1 publications with HIP2 and Liver
 Embryonic Tissue Antibodies  >1 publications with HIP2 and Embryonic Tissue
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