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anti-KAT5 antibody :: Mouse anti-Human HIV-1 Tat Interacting Protein, 60kD Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601906 anti-KAT5 antibody
Unit / Price
0.1 mg  /  $565 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HIV-1 Tat Interacting Protein, 60kD (KAT5), Monoclonal Antibody

 Also Known As   

HIV-1 Tat Interacting Protein, 60kD (HTATIP, HTATIP1, cPLA2-interacting Protein, ESA1, PLIP, TIP60)

 Product Synonym Names    Anti -HIV-1 Tat Interacting Protein, 60kD (HTATIP, HTATIP1, cPLA2-interacting Protein, ESA1, PLIP, TIP60)
 Product Gene Name   

anti-KAT5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (65479489..65487075). Location: 11q13
 OMIM    601409
 3D Structure    ModBase 3D Structure for Q92993
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    8C182
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human HIV-1 Tat Interacting Protein at ~60kD.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
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 Immunogen    Partial sequence from the internal region of recombinant full-length protein to human HIV-1 Tat Interacting Protein, 60kD
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-KAT5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-KAT5 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-KAT5 antibody   

Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-KAT5 antibody    Suitable for use in Western Blot and Immunocytochemistry.
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NCBI/Uniprot data below describe general gene information for KAT5. It may not necessarily be applicable to this product.
 NCBI GI #    119594838
 NCBI GeneID    10524
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 UniProt Primary Accession #    Q92993 [Other Products]
 UniProt Secondary Accession #    O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q9BWK7 [Other Products]
 UniProt Related Accession #    Q59EJ8; Q92993 [Other Products]
 Molecular Weight    58,582 Da [Similar Products]
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 NCBI Official Full Name    HIV-1 Tat interacting protein, 60kDa, isoform CRA_c
 NCBI Official Synonym Full Names    K(lysine) acetyltransferase 5
 NCBI Official Symbol    KAT5 [Similar Products]
 NCBI Official Synonym Symbols   
TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; HTATIP1
[Similar Products]
 NCBI Protein Information    histone acetyltransferase KAT5; OTTHUMP00000233811; OTTHUMP00000233812; OTTHUMP00000233813; OTTHUMP00000233848; K-acetyltransferase 5; cPLA2 interacting protein; lysine acetyltransferase 5; cPLA(2)-interacting protein; 60 kDa Tat-interactive protein; Tat interacting protein, 60kDa; histone acetyltransferase HTATIP; HIV-1 Tat interactive protein, 60kDa
 UniProt Protein Name    Histone acetyltransferase KAT5
 UniProt Synonym Protein Names   
60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein
 Protein Family    Histone acetyltransferase
 UniProt Gene Name    KAT5 [Similar Products]
 UniProt Synonym Gene Names    HTATIP; TIP60 [Similar Products]
 UniProt Entry Name    KAT5_HUMAN
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 NCBI Summary for KAT5    The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]
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 UniProt Comments for KAT5    Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.

Protein type: Nucleolus; EC 2.3.1.48; Nuclear receptor co-regulator; Acetyltransferase

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; transcription factor complex; NuA4 histone acetyltransferase complex; perinuclear region of cytoplasm; nucleolus; nucleus; cytosol

Molecular Function: protein binding; histone acetyltransferase activity; androgen receptor binding; metal ion binding; transcription coactivator activity; protein complex binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of interleukin-2 production; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; regulation of growth; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to ionizing radiation; histone acetylation; negative regulation of transcription, DNA-dependent
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 Research Articles on KAT5    1. Down-regulation of TIP60 is important for the malignant pathway of gastric carcinogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KAT5 antibodyPathways associated with anti-KAT5 antibody
 Reference Product  PubMed Publications
 CD82 antibody  >1 publications with KAT5 and CD82
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 IL-9 Signaling Pathway antibodies  IL-9 Signaling Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram
Diseases associated with anti-KAT5 antibodyOrgans/Tissues associated with anti-KAT5 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with KAT5 and Neoplasms
 Thyroid Neoplasms Antibodies  >9 publications with KAT5 and Thyroid Neoplasms
 Carcinoma, Papillary Antibodies  >8 publications with KAT5 and Carcinoma, Papillary
 Carcinoma, Small Cell Antibodies  >2 publications with KAT5 and Carcinoma, Small Cell
 Colorectal Neoplasms Antibodies  >1 publications with KAT5 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >1 publications with KAT5 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >9 publications with KAT5 and Thyroid
 Kidney Antibodies  >1 publications with KAT5 and Kidney
 Testis Antibodies  >1 publications with KAT5 and Testis
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