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anti-HLA-A antibody :: Mouse anti-Human HLA Class 2 Antigen DR4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS604087 anti-HLA-A antibody
Unit / Price
0.1 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HLA Class 2 Antigen DR4 (HLA-A), Monoclonal Antibody

★Popular Item★
 Also Known As   

HLA Class 2 Antigen DR4 (X-Reactive)

 Product Synonym Names    Anti -HLA Class 2 Antigen DR4 (X-Reactive)
 Product Gene Name   

anti-HLA-A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (29910247..29913661). Location: 6p21.3
 OMIM    142800
 3D Structure    ModBase 3D Structure for P01891
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 Clonality    Monoclonal
 Isotype    IgM
 Clone Number    8.L.335
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes HLA Class 2 Antigen-DR4. Additional crossreactivity occurs with related proteins. Specificity was determined at a 1:10 dilution by the microcytotoxicity test under standard NIH conditions.
 Purity/Purification    Ascites
 Form/Format    Supplied as a lyophilized powder from PBS, 1% BSA. Reconstitute with 100ul sterile ddH2O to make a 10X stock solution.
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 Cytotoxicity    Expected Results:
Cell death will occur in any test well where the HLA cell surface antigen is recognized by its matched anti-HLA antibody. Live lymphocytes indicate a negative reaction. Dead lymphocytes indicate a positive reaction.
Limitations:
Cell isolation difficulties, contamination of the lymphocyte preparation with red blood cells, monocytes, platelets or granulocytes, cell concentrations outside acceptable levels, bacterial contamination and/or change in pH of antisera may cause erroneous results.
 Source    Ascites fluid
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 Preparation and Storage    Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-HLA-A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-HLA-A antibody    Antibodies; Abs to HLA
 Applications Tested/Suitable for anti-HLA-A antibody   

This antibody has not been tested in methodologies other than Microcytoxicity Test. Potential applications include Flow Cytometry, Cell Typing, Tissue Staining and Chimerism Studies. Other applications not tested.

 Application Notes for anti-HLA-A antibody    Cytotoxicity: Add 0.9ml of 1% BSA in PBS to 100ul of 10X working dilution.
optimal dilutions to be determined by the researcher
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NCBI/Uniprot data below describe general gene information for HLA-A. It may not necessarily be applicable to this product.
 NCBI GI #    487911
 NCBI GeneID    3105
 NCBI Accession #    BAA04118.1 [Other Products]
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 UniProt Primary Accession #    P01891 [Other Products]
 UniProt Secondary Accession #    O19673; O19695; O19794; O19795; O43907; O77938; O98010; P10315; P79505; Q9MYA5; Q9MYC4 [Other Products]
 UniProt Related Accession #    P01891; P01892; P04439; P05534; P10314; P10316; P13746; P16189; P18462; P30443 [Other Products]
 Molecular Weight    40,909 Da [Similar Products]
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 NCBI Official Full Name    HLA-A11 antigen A11.2
 NCBI Official Synonym Full Names    major histocompatibility complex, class I, A
 NCBI Official Symbol    HLA-A [Similar Products]
 NCBI Official Synonym Symbols   
HLAA
[Similar Products]
 NCBI Protein Information    HLA class I histocompatibility antigen, A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain
 UniProt Protein Name    HLA class I histocompatibility antigen, A-68 alpha chain
 UniProt Synonym Protein Names   
Aw-68; HLA class I histocompatibility antigen, A-28 alpha chain; MHC class I antigen A*68
 Protein Family    HLA class I histocompatibility antigen
 UniProt Gene Name    HLA-A [Similar Products]
 UniProt Synonym Gene Names    HLAA [Similar Products]
 UniProt Entry Name    1A68_HUMAN
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 NCBI Summary for HLA-A    HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HLA-A    HLAA: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; Golgi apparatus; phagocytic vesicle membrane; cell surface; membrane; early endosome membrane; endoplasmic reticulum; integral to plasma membrane; plasma membrane; MHC class I protein complex; Golgi medial cisterna

Molecular Function: protein binding; peptide antigen binding; beta-2-microglobulin binding; T cell receptor binding; TAP binding; receptor binding

Biological Process: regulation of immune response; detection of bacterium; viral reproduction; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protection from natural killer cell mediated cytotoxicity; regulation of defense response to virus by virus; positive regulation of interferon-gamma production; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response

Disease: Severe Cutaneous Adverse Reaction, Susceptibility To
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 Research Articles on HLA-A    1. The most frequent haplotypes that may be associated with susceptibility to American cutaneous leishmaniasis were A*02 B*44 DRB1*07 (P = 0.0236) and A*24 B*35 DRB1*01 (P = 0.0236).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HLA-A antibodyOrgans/Tissues associated with anti-HLA-A antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7059 publications with HLA-A and Blood
 Kidney Antibodies  >1004 publications with HLA-A and Kidney
 Bone Antibodies  >903 publications with HLA-A and Bone
 Liver Antibodies  >457 publications with HLA-A and Liver
 Skin Antibodies  >421 publications with HLA-A and Skin
 Lung Antibodies  >369 publications with HLA-A and Lung
 Lymph Antibodies  >190 publications with HLA-A and Lymph
 Prostate Antibodies  >156 publications with HLA-A and Prostate
 Embryonic Tissue Antibodies  >146 publications with HLA-A and Embryonic Tissue
 Placenta Antibodies  >140 publications with HLA-A and Placenta
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