Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow HLA-DP/-DQ/-DR rightarrow Monoclonal HLA-DP/-DQ/-DR  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • CNIH2 Antibody
 • Rho Kinase-ROCKII (Paired T249) (Rho Kinase-ROCKII (Paired T... Antibody
 • Podocin (NPHS2) Recombinant Protein
 • T4 Antibody
 • Tau Protein ELISA Kit
 • Heparanase 1 (HPSE) Antibody
 • Klotho Beta (KLbeta) ELISA Kit
 • solute carrier family 19 (folate transporter) , member 1 (Sl... ELISA Kit
 • Matrix Metalloproteinase 9 (MMP-9) ELISA Kit
 • Parathyroid Hormone (PTH) Antibody
 • Pax ELISA Kit
 • IgY, H&L Chain Secondary Antibody
 • Interferon Gamma (IFN-gamma) ELISA Kit
 • TBG ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-HLA-DP/-DQ/-DR antibody :: Mouse HLA-DP/-DQ/-DR Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS4380017
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HLA-DP/-DQ/-DR, Monoclonal Antibody

★Popular Item★
 Also Known As   

HLA-DP/-DQ/-DR (MHC II)

 Product Synonym Names    HLA-DPB1; HLA-DQA1; HLA-DQB1; HLA-DRA; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5;
 Product Gene Name   

anti-HLA-DP/-DQ/-DR antibody

[Similar Products]
 Product Synonym Gene Name    HLA-DP; HLA-DQ; HLA-DR [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for P04440
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    CR3/43
 Host    Mouse
 Species Reactivity    Human. Others not known.
Section Bar
 Specificity    Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an  chain (36kDa) and a  chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six  and ten  chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Section Bar
 Immunogen    Cells from human tonsil
 Cellular Localization    Cell Surface
 Hu-chromosome Location    6p21.3 (HLA-DP & HLA-DR)
 Positive Control    Raji cells. Tonsil or lymph node
Section Bar
 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-HLA-DP/-DQ/-DR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-HLA-DP/-DQ/-DR antibody   

Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-HLA-DP/-DQ/-DR antibody    IF: 0.5-1ug/ml
IHC-F: 1-2ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
Section Bar
 Immunohistochemistry (IHC) of anti-HLA-DP/-DQ/-DR antibody    Formalin-fixed, paraffin-embedded human Tonsil stained with HLA-DP/-DQ/-DR Monoclonal Antibody (CR3/43).
anti-HLA-DP/-DQ/-DR antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-HLA-DP/-DQ/-DR antibody    Formalin-fixed, paraffin-embedded human Tonsil stained with HLA-DP/-DQ/-DR Monoclonal Antibody (CR3/43).
anti-HLA-DP/-DQ/-DR antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for HLA-DP/-DQ/-DR. It may not necessarily be applicable to this product.
 NCBI GI #    24797076
 NCBI GeneID    3115
 NCBI Accession #    NP_002112.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002121.5 [Other Products]
Section Bar
 UniProt Primary Accession #    P04440 [Other Products]
 UniProt Secondary Accession #    A0PFJ7; A5I886; A8YPB3; B5U8B4; B7VF80; B7VF87; B8ZX68; B8ZYT0; B9W5S8; B9W6F7; B9W6F9 [Other Products]
 UniProt Related Accession #    P04440 [Other Products]
 Molecular Weight    36kDa (alpha chain); 27kDa (beta chain)
Table BarTOPTable Bar
 NCBI Official Full Name    HLA class II histocompatibility antigen, DP beta 1 chain
 NCBI Official Synonym Full Names    major histocompatibility complex, class II, DP beta 1
 NCBI Official Symbol    HLA-DPB1 [Similar Products]
 NCBI Official Synonym Symbols   
DPB1; HLA-DP; HLA-DPB; HLA-DP1B
[Similar Products]
 NCBI Protein Information    HLA class II histocompatibility antigen, DP beta 1 chain
 UniProt Protein Name    HLA class II histocompatibility antigen, DP beta 1 chain
 UniProt Synonym Protein Names   
HLA class II histocompatibility antigen, DP(W4) beta chain; MHC class II antigen DPB1
 UniProt Gene Name    HLA-DPB1 [Similar Products]
 UniProt Synonym Gene Names    HLA-DP1B [Similar Products]
Section Bar
 NCBI Summary for HLA-DP/-DQ/-DR    HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for HLA-DP/-DQ/-DR    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
Table BarTOPTable Bar
 

Product References and Citations for anti-HLA-DP/-DQ/-DR antibody

   Gatter et al. 1982. J Clin Pathol. 35(11):1253-67. Gatter et al. 1982. Semin Oncol. 9(4):517-25.
Section Bar
 Research Articles on HLA-DP/-DQ/-DR    1. The rs3117242 of HLA-DPB1 could be considered a genetic risk factor for granulomatosis with polyangiitis in Chinese Han people.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-HLA-DP/-DQ/-DR antibodyDiseases associated with anti-HLA-DP/-DQ/-DR antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Diseases, Interstitial Antibodies  >54 publications with HLA-DP/-DQ/-DR and Lung Diseases, Interstitial
 Nervous System Diseases Antibodies  >50 publications with HLA-DP/-DQ/-DR and Nervous System Diseases
 Berylliosis Antibodies  >37 publications with HLA-DP/-DQ/-DR and Berylliosis
 Skin Diseases Antibodies  >34 publications with HLA-DP/-DQ/-DR and Skin Diseases
 Multiple Sclerosis Antibodies  >34 publications with HLA-DP/-DQ/-DR and Multiple Sclerosis
 Arthritis, Rheumatoid Antibodies  >31 publications with HLA-DP/-DQ/-DR and Arthritis, Rheumatoid
 Liver Diseases Antibodies  >30 publications with HLA-DP/-DQ/-DR and Liver Diseases
 Lymphoma Antibodies  >24 publications with HLA-DP/-DQ/-DR and Lymphoma
 Asthma Antibodies  >22 publications with HLA-DP/-DQ/-DR and Asthma
 Sarcoidosis Antibodies  >19 publications with HLA-DP/-DQ/-DR and Sarcoidosis
Organs/Tissues associated with anti-HLA-DP/-DQ/-DR antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >195 publications with HLA-DP/-DQ/-DR and Blood
 Bone Antibodies  >64 publications with HLA-DP/-DQ/-DR and Bone
 Bone Marrow Antibodies  >60 publications with HLA-DP/-DQ/-DR and Bone Marrow
 Lung Antibodies  >32 publications with HLA-DP/-DQ/-DR and Lung
 Liver Antibodies  >18 publications with HLA-DP/-DQ/-DR and Liver
 Skin Antibodies  >14 publications with HLA-DP/-DQ/-DR and Skin
 Kidney Antibodies  >12 publications with HLA-DP/-DQ/-DR and Kidney
 Brain Antibodies  >11 publications with HLA-DP/-DQ/-DR and Brain
 Thyroid Antibodies  >10 publications with HLA-DP/-DQ/-DR and Thyroid
 Heart Antibodies  >9 publications with HLA-DP/-DQ/-DR and Heart
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions