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anti-HLA-DR antibody :: Rat anti-Human HLA-DR Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS520342
Testing Data
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HLA-DR, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Human HLA-DR, FITC, (Clone YE2/36 HLK) (rat IgG2a)

 Product Synonym Names    HLA-DR, FITC, (Clone YE2/36 HLK) (rat IgG2a); Purified Anti-Human HLA-DR Monoclonal Antibody
 Product Gene Name   

anti-HLA-DR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (32627241..32634466, complement). Location: 6p21.3
 3D Structure    ModBase 3D Structure for Q29900
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 Clonality    Monoclonal
 Isotype    Rat IgG2a
 Clone Number    YE2/36 HLK
 Host    Rat
 Species Reactivity    Human
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 Specificity    HLA-DR (HLA-DR Ia alpha chain, cross reactive with mouse H-2, I-A sub-region)
 Form/Format    FITC
 Concentration    Antibody Concentration: 1.0 ug/106 cells (lot specific)
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 Immunogen    EHR-B Ramos cells
 Donor    immunized AO rat spleen cells
 Fusion Partner    Y3 Ag1.2.3 rat myeloma
 Presentation    conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
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 Preparation and Storage    For all formats, store at 4 degree C. DO NOT FREEZE PE conjugate. For long term storage (Ascites, Purified, Biotin and FITC), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-HLA-DR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HLA-DR antibody

   purified anti-human HLA-DR monoclonal antibody recognizes an epitope on the Ia alpha chain of the Human lymphocyte antigen. This antibody has also been shown to recognize the H-2, I-A region of the mouse.
 Applications Tested/Suitable for anti-HLA-DR antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-HLA-DR antibody    flow cytometry, immunofluorescence1 and immunohistochemistry3 (frozen and paraffin sections).
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 Testing Data of anti-HLA-DR antibody    anti-HLA-DR antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for HLA-DR. It may not necessarily be applicable to this product.
 NCBI GI #    642238
 NCBI GeneID    3119
 NCBI Accession #    CAA23788.1 [Other Products]
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 UniProt Primary Accession #    Q29900 [Other Products]
 UniProt Related Accession #    P01920 [Other Products]
 Molecular Weight    5,068 Da
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 NCBI Official Full Name    HLA-DR
 NCBI Official Synonym Full Names    major histocompatibility complex, class II, DQ beta 1
 NCBI Official Symbol    HLA-DQB1 [Similar Products]
 NCBI Official Synonym Symbols   
IDDM1; CELIAC1; HLA-DQB
[Similar Products]
 NCBI Protein Information    HLA class II histocompatibility antigen, DQ beta 1 chain; MHC DQ beta; MHC class2 antigen; lymphocyte antigen; MHC class II antigen DQB1; MHC class II DQ beta chain; MHC class II antigen HLA-DQ-beta-1; MHC class II HLA-DQ beta glycoprotein
 UniProt Protein Name    HLA-DR
 UniProt Entry Name    Q29900_HUMAN
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 NCBI Summary for HLA-DR    HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
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 UniProt Comments for HLA-DR    HLA-DQB1: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Belongs to the MHC class II family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; membrane; lysosomal membrane; plasma membrane; endosome membrane; trans-Golgi network membrane; MHC class II protein complex

Molecular Function: MHC class II receptor activity; peptide antigen binding

Biological Process: humoral immune response mediated by circulating immunoglobulin; cytokine and chemokine mediated signaling pathway; T cell costimulation; antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; immunoglobulin production during immune response; T cell receptor signaling pathway

Disease: Celiac Disease; Creutzfeldt-jakob Disease; Multiple Sclerosis, Susceptibility To
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 Research Articles on HLA-DR    1. Data indicate that DRB1*13:02-DQB1*06:04 and DRB1*15:01-DQB1*06:02 haplotypes share the same DQA1*01:02 allele.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HLA-DR antibodyOrgans/Tissues associated with anti-HLA-DR antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >668 publications with HLA-DR and Blood
 Pancreas Antibodies  >99 publications with HLA-DR and Pancreas
 Skin Antibodies  >73 publications with HLA-DR and Skin
 Liver Antibodies  >70 publications with HLA-DR and Liver
 Bone Marrow Antibodies  >66 publications with HLA-DR and Bone Marrow
 Brain Antibodies  >56 publications with HLA-DR and Brain
 Thyroid Antibodies  >52 publications with HLA-DR and Thyroid
 Eye Antibodies  >48 publications with HLA-DR and Eye
 Lung Antibodies  >38 publications with HLA-DR and Lung
 Heart Antibodies  >35 publications with HLA-DR and Heart
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