View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List anti-HMGB1 antibody :: Mouse anti-Human HMGB1 Monoclonal Antibody Catalog # MBS690349 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name HMGB1, Monoclonal Antibody Full Product Name Mouse Anti-Human HMGB1 Product Synonym Names HMGB1; HMG1; HMG3; SBP-1 Product Gene Name anti-HMGB1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: 13; NC_000013.11 (30458740..30465944, complement). Location: 13q12 OMIM 163905 3D Structure ModBase 3D Structure for P09429 Clonality Monoclonal Isotype IgG2 Clone Number (6X30) Host Mouse Species Reactivity Human Form/Format Lyophilized Antibody Generation This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of HMGB-1. Reconstitution Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. Preparation and Storage Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity. ISO Certification Manufactured in an ISO 9001:2008 Certified Laboratory. Other Notes Small volumes of anti-HMGB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-HMGB1 antibody Human High-mobility group box 1 protein (HMGB1), previously known as HMG1 or amphoterin, is a member of the high mobility group box family of non- histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa, 215 amino acid (aa) single chain polypeptide containing three domains: two N-terminal globular, 70 aa positively charged DNA-binding domains (HMG boxes A and B), and a negatively charged 30 aa C-terminal region that contains only Asp and Glu. Residues 27-43 and 178-184 contain a NLS. Posttranslational modifications of the molecule have been reported, with acetylation occurring on as many as 17 lysine residues. HMGB1 is expressed at high levels in almost all cells. It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins. It is now known that HMGB1 can also act extracellularly, both as an inflammatory mediator that promotes monocyte migration and cytokine secretion, and as a mediator of T celldendritic cell interaction. The cytokine activity of HBMG1 is restricted to the HMG B box, while the A box is associated with the helixloophelix domain of transcription factors. HMBG1 is released in response to cell death and as a secretion product. Although HMBG 1 does not possess a classic signal sequence, it appears to be secreted as an acetylated form via secretory endolysosome exocytosis. Once secreted, HMGB1 transduces cellular signals through its high affinity receptor, RAGE and, possibly, TLR2 and TLR4. Human HMGB1 is 100% aa identical to canine HMGB1 and 99% aa identical to mouse, rat, bovine and porcine HMGB1, respectively. Applications Tested/Suitable for anti-HMGB1 antibody Western Blot (WB) TOP NCBI/Uniprot data below describe general gene information for HMGB1. It may not necessarily be applicable to this product. NCBI GI # 4504425 NCBI GeneID 3146 NCBI Accession # NP_002119.1 [Other Products] NCBI GenBank Nucleotide # NM_002128.4 [Other Products] UniProt Primary Accession # P09429 [Other Products] UniProt Secondary Accession # Q14321; Q5T7C3; Q6IBE1; A5D8W9[Other Products] UniProt Related Accession # P09429[Other Products] Molecular Weight 24,894 Da TOP NCBI Official Full Name high mobility group protein B1 NCBI Official Synonym Full Names high mobility group box 1 NCBI Official Symbol HMGB1 [Similar Products] NCBI Official Synonym Symbols HMG1; HMG3; SBP-1 [Similar Products] NCBI Protein Information high mobility group protein B1; HMG-1; Amphoterin; high-mobility group box 1; high mobility group protein 1; Sulfoglucuronyl carbohydrate binding protein; high-mobility group (nonhistone chromosomal) protein 1 UniProt Protein Name High mobility group protein B1 UniProt Synonym Protein Names High mobility group protein 1 Protein Family High mobility group protein UniProt Gene Name HMGB1 [Similar Products] UniProt Synonym Gene Names HMG1; HMG-1 [Similar Products] UniProt Entry Name HMGB1_HUMAN TOP TOP UniProt Comments for HMGB1 Function: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells By similarity.Subunit structure: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 By similarity.Subcellular location: Nucleus. Chromosome. Sequence similarities: Belongs to the HMGB family.Contains 2 HMG box DNA-binding domains. Research Articles on HMGB1 1. Patients with 1176G/G genotype of HMGB1 gene are more likely to have a progressive status in chronic hepatitis B infection. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-HMGB1 antibody Reference Product PubMed Publications TNF antibody >388 publications with HMGB1 and TNF TLR4 antibody >284 publications with HMGB1 and TLR4 TP53 antibody >6 publications with HMGB1 and TP53 AGER antibody >3 publications with HMGB1 and AGER DIF antibody >2 publications with HMGB1 and DIF PLAT antibody >1 publications with HMGB1 and PLAT Pathways associated with anti-HMGB1 antibody Products by Pathway Pathway Diagram Activated TLR4 Signalling Pathway antibodies Activated TLR4 Signalling Pathway Diagram Activation Of DNA Fragmentation Factor Pathway antibodies Activation Of DNA Fragmentation Factor Pathway Diagram Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Induced DNA Fragmentation Pathway antibodies Apoptosis Induced DNA Fragmentation Pathway Diagram Apoptotic Execution Phase Pathway antibodies Apoptotic Execution Phase Pathway Diagram Base Excision Repair Pathway antibodies Base Excision Repair Pathway Diagram Base Excision Repair Pathway antibodies Base Excision Repair Pathway Diagram Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram Diseases associated with anti-HMGB1 antibody Disease Name Pubmed Publications Inflammation Antibodies >1109 publications with HMGB1 and Inflammation Necrosis Antibodies >637 publications with HMGB1 and Necrosis Sepsis Antibodies >433 publications with HMGB1 and Sepsis Neoplasms Antibodies >421 publications with HMGB1 and Neoplasms Disease Models, Animal Antibodies >318 publications with HMGB1 and Disease Models, Animal Lung Diseases Antibodies >179 publications with HMGB1 and Lung Diseases Liver Diseases Antibodies >133 publications with HMGB1 and Liver Diseases Heart Diseases Antibodies >96 publications with HMGB1 and Heart Diseases Myocardial Ischemia Antibodies >86 publications with HMGB1 and Myocardial Ischemia Atherosclerosis Antibodies >70 publications with HMGB1 and Atherosclerosis Organs/Tissues associated with anti-HMGB1 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >952 publications with HMGB1 and Blood Liver Antibodies >339 publications with HMGB1 and Liver Lung Antibodies >304 publications with HMGB1 and Lung Brain Antibodies >252 publications with HMGB1 and Brain Vascular Antibodies >245 publications with HMGB1 and Vascular Muscle Antibodies >141 publications with HMGB1 and Muscle Heart Antibodies >128 publications with HMGB1 and Heart Kidney Antibodies >125 publications with HMGB1 and Kidney Bone Antibodies >102 publications with HMGB1 and Bone Nerve Antibodies >95 publications with HMGB1 and Nerve TOP © 2006-24 MyBioSource.com. 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