Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow HP rightarrow Monoclonal HP  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • MT3 cDNA Clone
 • LPAM1 Antibody
 • Pepsin (PP) ELISA Kit
 • Tumor Necrosis Factor alpha (TNFalpha) ELISA Kit
 • Akt Antibody
 • Ultrasensitivity Thyroxine (U-T4) ELISA Kit
 • BACE2 B Antibody
 • Interferon alpha (IFN-alpha) ELISA Kit
 • P2RX7 Antibody
 • cubilin (intrinsic factor-cobalamin receptor) (CUBN) ELISA Kit
 • Serine-threonine-protein phosphatase 2A 65 kDa regulatory su... Recombinant Protein
 • IL10 cDNA Clone
 • CATSPER1 Antibody
 • Corticotropin Releasing Hormone (CRH) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-HP antibody :: Mouse anti-Human HP / Haptoglobin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245473
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HP / Haptoglobin, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal [clone 2F4] (IgG1,k) to Human HP / Haptoglobin

 Product Synonym Names    Anti-HP / Haptoglobin Antibody (clone 2F4) IHC-plus; HP; Binding peptide; Haptoglobin alpha(1S)-beta; Haptoglobin; beta polypeptide; Haptoglobin; Haptoglobin alpha(2FS)-beta; Haptoglobin; alpha polypeptide; HP2ALPHA2; BP; Zonulin; HPA1S; Human HP; Haptoglobin
 Product Gene Name   

anti-HP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    gene 614081
 3D Structure    ModBase 3D Structure for P00738
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    2F4
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Purity/Purification    Purified
 Form/Format    HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
 Concentration    1 mg/ml (lot specific)
Section Bar
 Target    HP/Haptoglobin
 Target Species    Human
 Immunogen Description    Protein purified from Human plasma.
 Immunogen    HP / Haptoglobin antibody was raised against protein purified from Human plasma.
Section Bar
 Preparation and Storage    Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-HP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-HP antibody

   The Haptoglobin (HP) gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin.
 Applications Tested/Suitable for anti-HP antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-HP antibody    ELISA, IHC-P (1:50), WB (1:2000)
Usage: Immunohistochemistry: MBS245547 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS245547 was determined to be 1:50.
Section Bar
 Immunohistochemistry (IHC) of anti-HP antibody    Anti-Haptoglobin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
anti-HP antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-HP antibody    Anti-Haptoglobin antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
anti-HP antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Western Blot (WB) of anti-HP antibody     
anti-HP antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for HP. It may not necessarily be applicable to this product.
 NCBI GI #    4826762
 NCBI GeneID    3240
 NCBI Accession #    NP_005134.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005143.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P00738 [Other Products]
 UniProt Secondary Accession #    P00737; Q0VAC4; Q0VAC5; Q2PP15; Q3B7J0; Q6LBY9; Q9UC67; B0AZL5 [Other Products]
 UniProt Related Accession #    P00738 [Other Products]
 Molecular Weight    38,452 Da
Table BarTOPTable Bar
 NCBI Official Full Name    haptoglobin isoform 1 preproprotein
 NCBI Official Synonym Full Names    haptoglobin
 NCBI Official Symbol    HP [Similar Products]
 NCBI Official Synonym Symbols   
BP; HPA1S; HP2ALPHA2
[Similar Products]
 NCBI Protein Information    haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide
 UniProt Protein Name    Haptoglobin
 UniProt Synonym Protein Names   
ZonulinCleaved into the following 2 chains:Haptoglobin alpha chain; Haptoglobin beta chain
 UniProt Gene Name    HP [Similar Products]
 UniProt Entry Name    HPT_HUMAN
Section Bar
 NCBI Summary for HP    This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Section Bar
 UniProt Comments for HP    HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: extracellular space; extracellular region

Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity

Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; metabolic process; immune system process; defense response to bacterium; negative regulation of oxidoreductase activity; acute-phase response; defense response

Disease: Anhaptoglobinemia
Table BarTOPTable Bar
 Research Articles on HP    1. Antimicrobial protein, zonulin, has antibacterial activity and functions in regulation of intestinal barrier function.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-HP antibodyPathways associated with anti-HP antibody
 Reference Product  PubMed Publications
 CD163 antibody  >59 publications with HP and CD163
 APOE antibody  >28 publications with HP and APOE
 IL6 antibody  >27 publications with HP and IL6
 HBA1 antibody  >25 publications with HP and HBA1
 APOA1 antibody  >11 publications with HP and APOA1
 HBB antibody  >4 publications with HP and HBB
 MIS12 antibody  >2 publications with HP and MIS12
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with anti-HP antibodyOrgans/Tissues associated with anti-HP antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1582 publications with HP and Cardiovascular Diseases
 Inflammation Antibodies  >1090 publications with HP and Inflammation
 Heart Diseases Antibodies  >719 publications with HP and Heart Diseases
 Hypersensitivity Antibodies  >642 publications with HP and Hypersensitivity
 Liver Diseases Antibodies  >586 publications with HP and Liver Diseases
 Hypertension Antibodies  >469 publications with HP and Hypertension
 Kidney Diseases Antibodies  >459 publications with HP and Kidney Diseases
 Autoimmune Diseases Antibodies  >456 publications with HP and Autoimmune Diseases
 Necrosis Antibodies  >451 publications with HP and Necrosis
 Fibrosis Antibodies  >434 publications with HP and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5432 publications with HP and Blood
 Brain Antibodies  >1242 publications with HP and Brain
 Liver Antibodies  >1203 publications with HP and Liver
 Lung Antibodies  >1114 publications with HP and Lung
 Muscle Antibodies  >722 publications with HP and Muscle
 Kidney Antibodies  >672 publications with HP and Kidney
 Connective Tissue Antibodies  >322 publications with HP and Connective Tissue
 Bone Marrow Antibodies  >217 publications with HP and Bone Marrow
 Adipose Tissue Antibodies  >174 publications with HP and Adipose Tissue
 Ovary Antibodies  >143 publications with HP and Ovary
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions