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anti-HR antibody :: Mouse anti-Human HR Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120396
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HR, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human HR

 Product Synonym Names    Homo sapiens hairless homolog (mouse), mRNA (cDNA clone MGC:70516 IMAGE:6138631), complete cds.; HSA277165; AU
 Product Gene Name   

anti-HR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146550
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    366C2b
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-HR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HR antibody

   This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. Mutations in this gene have been documented in cases of autosomal recessive congenital alopecia and atrichia with papular lesions.[NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-HR antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

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 Quality Control of anti-HR antibody    Western blot analysis of immunized recombinant protein, using anti-HR monoclonal antibody.
anti-HR antibody Quality Control image
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 Quality Control #2 of anti-HR antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-HR antibody Quality Control #2 image
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 Immunocytochemistry (ICC) of anti-HR antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-HR mAb. [366C2b-1]
anti-HR antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for HR. It may not necessarily be applicable to this product.
 NCBI GI #    45501002
 NCBI GeneID    55806
 NCBI Accession #    BC067128 [Other Products]
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 UniProt Secondary Accession #    Q6GS30; Q96H33; Q9NPE1 [Other Products]
 UniProt Related Accession #    O43593 [Other Products]
 Molecular Weight    121,857 Da
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 NCBI Official Full Name    Homo sapiens hairless homolog (mouse), mRNA
 NCBI Official Synonym Full Names    hair growth associated
 NCBI Official Symbol    HR [Similar Products]
 NCBI Official Synonym Symbols   
AU; MUHH; ALUNC; HYPT4; MUHH1; HSA277165
[Similar Products]
 NCBI Protein Information    lysine-specific demethylase hairless; hairless homolog; protein hairless
 UniProt Protein Name    Lysine-specific demethylase hairless
 Protein Family    Hrp65 protein
 UniProt Gene Name    HR [Similar Products]
 UniProt Entry Name    HAIR_HUMAN
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 NCBI Summary for HR    This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
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 UniProt Comments for HR    HR: May act as a transcription factor that could act on to regulate one of the phases of hair growth. Defects in HR are the cause of alopecia universalis congenita (ALUNC). ALUNC is a rare autosomal recessive form of hair loss characterized by hair follicles without hair. Defects in HR are the cause of atrichia with papular lesions (APL); also known as congenital atrichia. APL is an autosomal recessive disease characterized by papillary lesions over most of the body and almost complete absence of hair. Defects in HR are the cause of hypotrichosis type 4 (HYPT4). An autosomal dominant condition characterized by reduced amount of hair, alopecia, little or no eyebrows, eyelashes or body hair, and coarse, wiry, twisted hair in early childhood. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 8p21.2

Cellular Component: nuclear body; nucleus

Molecular Function: DNA binding; metal ion binding; oxidoreductase activity; transcription factor activity; transcription corepressor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of transcription, DNA-dependent

Disease: Hypotrichosis 4; Alopecia Universalis Congenita; Atrichia With Papular Lesions
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 Research Articles on HR    1. study reports two cases of Marie Unna hereditary hypotrichosis; a novel nonsense mutation of U2HR was identified in the second case, but no causative mutation in U2HR or EPS8L3 was found in the first case
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HR antibodyDiseases associated with anti-HR antibody
 Reference Product  PubMed Publications
 VDR antibody  >66 publications with HR and VDR
 HMGB1 antibody  >35 publications with HR and HMGB1
 HDAC1 antibody  >16 publications with HR and HDAC1
 HDAC2 antibody  >11 publications with HR and HDAC2
 HDAC3 antibody  >8 publications with HR and HDAC3
 SFRP2 antibody  >3 publications with HR and SFRP2
 HDAC5 antibody  >2 publications with HR and HDAC5
 THRA antibody  >1 publications with HR and THRA
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >7116 publications with HR and Brain Diseases
 Hypertension Antibodies  >7040 publications with HR and Hypertension
 Lung Diseases Antibodies  >6679 publications with HR and Lung Diseases
 Disease Models, Animal Antibodies  >5260 publications with HR and Disease Models, Animal
 Kidney Diseases Antibodies  >5022 publications with HR and Kidney Diseases
 Inflammation Antibodies  >5018 publications with HR and Inflammation
 Necrosis Antibodies  >4529 publications with HR and Necrosis
 Liver Diseases Antibodies  >4148 publications with HR and Liver Diseases
 Breast Neoplasms Antibodies  >3875 publications with HR and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >3178 publications with HR and Neoplasms, Experimental
Organs/Tissues associated with anti-HR antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >66219 publications with HR and Blood
 Heart Antibodies  >32754 publications with HR and Heart
 Brain Antibodies  >14563 publications with HR and Brain
 Kidney Antibodies  >10645 publications with HR and Kidney
 Lung Antibodies  >9366 publications with HR and Lung
 Skin Antibodies  >5579 publications with HR and Skin
 Eye Antibodies  >3651 publications with HR and Eye
 Intestine Antibodies  >3534 publications with HR and Intestine
 Stomach Antibodies  >2672 publications with HR and Stomach
 Embryonic Tissue Antibodies  >1622 publications with HR and Embryonic Tissue
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