NP_006635
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97,460 Da
NCBI Official Full Name
heat shock protein 105 kDa isoform 1
NCBI Official Synonym Full Names
heat shock protein family H (Hsp110) member 1
NCBI Official Synonym Symbols
HSP105; HSP105A; HSP105B; NY-CO-25 [Similar Products]
NCBI Protein Information
heat shock protein 105 kDa
UniProt Protein Name
Heat shock protein 105 kDa
UniProt Synonym Protein Names
Antigen NY-CO-25; Heat shock 110 kDa protein
UniProt Synonym Gene Names
NCBI Summary for HSP105alpha
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
UniProt Comments for HSP105alpha
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities ().
Product References and Citations for anti-HSP105alpha antibody
Wang XY., et al. (2001) J Immunol. 166 (1):490-7.; Yamagishi N., et al. (2006) Exp Cell Res. 312 (17):3215-23. ;Saito Y., et al. (2007) Exp Cell Res. 313 (17):3707-17.
Research Articles on HSP105alpha
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Disclaimer
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Products associated with anti-HSP105alpha antibody
Pathways associated with anti-HSP105alpha antibody
Diseases associated with anti-HSP105alpha antibody
Organs/Tissues associated with anti-HSP105alpha antibody
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