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anti-hspa1l antibody :: Rat Heat Shock Cognate Protein 70 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS600190 anti-hspa1l antibody
Unit / Price
0.05 mg  /  $465 +1 FREE 8GB USB
0.2 mg  /  $740 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heat Shock Cognate Protein 70 (hspa1l), Monoclonal Antibody

 Also Known As   

Heat Shock Cognate Protein 70 (HSC70, HSP73) (Biotin)

 Product Synonym Names    Anti -Heat Shock Cognate Protein 70 (HSC70, HSP73) (Biotin)
 Product Gene Name   

anti-hspa1l antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    6i2
 Host    Rat
 Species Reactivity    Bovine, Canine, Chicken, Hamster, Human, Mouse, Porcine, Rabbit, Rat, Sheep
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 Specificity    Detects a ~73kD protein, corresponding to the apparent molecular mass of Hsc70 on SDS-PAGE Western Blot, in samples from human, mouse, rat, bovine, canine, chicken, guinea pig, hamster, monkey, porcine, rabbit, sheep and turtle origins.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. Conjugated to Biotin.
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 Immunogen    Sodium-arsenite-treated heat-resistant variants of Chinese hamster cells (1).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add glycerol (40-50%)aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-hspa1l antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-hspa1l antibody

   This product is the same antibody as H1831-25A but conjugated to Biotin.

The 70kD heat shock cognate protein, Hsc70 is closely related biochemically and biologically to Hsp70 and is part of the Hsp70 family which contains a number of highly related protein isoforms ranging in size from 66kD to 78kD. These proteins include both cognate members which are found within major intracellular compartments and highly inducible isoforms which appear to be predominantly cytoplasmic or nuclear in distribution (3). Members of the Hsp70 family are molecular chaperones which are involved in many cellular functions such as protein folding, transport, maturation and degradation and they exert their function in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregation and misfolding. The binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (4). Recent data has demonstrated that BAG-1 which possesses a ubiquitin-like domain at its amino terminus modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal a role of BAG-1 as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome (5). There is also experimental data which shows that the ATPase domain and the substrate binding domain of Hsc70 cooperate and form a cochaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp) which is essential for normal neurotransmitter release (6).
 Product Categories/Family for anti-hspa1l antibody    Antibodies; Abs to Heat Shock Proteins
 Applications Tested/Suitable for anti-hspa1l antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

 Application Notes for anti-hspa1l antibody    Suitable for use in ELISA, Western Blotting, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation, FACS (2,10), Immunoelectron Microscopy (9).
Dilution: ELISA: 1:100-1:750 (15,16)
Western Blot: 1ug/ml (2,4,11)
Immunoprecipitation: 5ug/ml (4,13,14)
Immunohistochemistry: 1:200 (3,12)
Immunocytochemistry: 5ug/ml (4,11)
Electron Microscopy: 1:1000 (9)
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NCBI/Uniprot data below describe general gene information for hspa1l. It may not necessarily be applicable to this product.
 NCBI GI #    148222597
 NCBI GeneID    379760
 NCBI Accession #    NP_001080068.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001086599.1 [Other Products]
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 NCBI Official Full Name    heat shock 70kDa protein 1-like
 NCBI Official Synonym Full Names    heat shock 70kDa protein 1-like
 NCBI Official Symbol    hspa1l [Similar Products]
 NCBI Official Synonym Symbols   
hsc70; hsc70.I; MGC52655
[Similar Products]
 NCBI Protein Information    heat shock 70kDa protein 1-like; heat shock cognate protein 70
 Protein Family    Heat shock 70 kDa protein
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 Research Articles on hspa1l    1. csp interaction with Hsc 70 molecular chaperones is vital for regulated secretion in Xenopus oocytes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-hspa1l antibodyOrgans/Tissues associated with anti-hspa1l antibody
 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with hspa1l and Bone
 Connective Tissue Antibodies  >4 publications with hspa1l and Connective Tissue
 Heart Antibodies  >3 publications with hspa1l and Heart
 Muscle Antibodies  >3 publications with hspa1l and Muscle
 Brain Antibodies  >3 publications with hspa1l and Brain
 Vascular Antibodies  >2 publications with hspa1l and Vascular
 Embryonic Tissue Antibodies  >2 publications with hspa1l and Embryonic Tissue
 Ear Antibodies  >1 publications with hspa1l and Ear
 Kidney Antibodies  >1 publications with hspa1l and Kidney
 Umbilical Cord Antibodies  >1 publications with hspa1l and Umbilical Cord
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