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anti-HSPH1 antibody :: Mouse Heat Shock Protein 105 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140259 anti-HSPH1 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heat Shock Protein 105 (HSPH1), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Heat Shock Protein 105

 Product Synonym Names    HSPH1 Antibody; Heat Shock Protein 105, Mouse Anti Human; HSPH1; Heat Shock protein 105kDa; 110kDa protein 1; Heat shock 110 kDa protein; HSP110; HSP105alpha; Antigen NY-CO-25; HSP105; HSP105A; HSP105B; KIAA0201; NY-CO-25; DKFZp686M05240
 Product Gene Name   

anti-HSPH1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610703
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 Clonality    Monoclonal
 Isotype    IgG2b heavy chain and kappa light chain
 Clone Number    PJ1G12AT
 Host    Mouse
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 Purity/Purification    HSPH1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
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 Immunogen    Anti-human HSPH1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HSPH1 amino acids 1-858 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-HSPH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HSPH1 antibody

   Introduction: HSPH1 analysis is used as an indicator and as a diagnostic aid in problematic lesions. HSPH1 chaperones the responses to endoplasmic reticulum (ER) stress during its interactions with GRP78 and GSK3, and without HSP105 cell death following ER stress proceeds by a non-caspase-3-dependent process. HSPH1 is highly expressed in a variety of human tumors. HSPH1 is a mammalian member of the HSP105/110 family, a diverged subgroup of the HSP70 family. HSP105 has 2 isoforms, alpha and beta. Hsp105a associates with Hsp70/Hsc70 as complexes in vivo and regulates the chaperone activity of Hsp70/Hsc70 negatively in vitro and in vivo.
 Product Categories/Family for anti-HSPH1 antibody    MONOCLONAL ANTIBODIES, ANTI-HUMAN HEAT SHOCK PROTEINS; Monoclonal Antibodies; Anti Human Heat Shock Protein
 Applications Tested/Suitable for anti-HSPH1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-HSPH1 antibody    HSPH1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.
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NCBI/Uniprot data below describe general gene information for HSPH1. It may not necessarily be applicable to this product.
 NCBI GI #    42544159
 NCBI GeneID    10808
 NCBI Accession #    NP_006635.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006644.3 [Other Products]
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 UniProt Secondary Accession #    O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q9UPC4; B4DYH1 [Other Products]
 UniProt Related Accession #    Q92598 [Other Products]
 Molecular Weight    97,460 Da
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 NCBI Official Full Name    heat shock protein 105 kDa isoform 1
 NCBI Official Synonym Full Names    heat shock 105kDa/110kDa protein 1
 NCBI Official Symbol    HSPH1 [Similar Products]
 NCBI Official Synonym Symbols   
HSP105; HSP105A; HSP105B; NY-CO-25
[Similar Products]
 NCBI Protein Information    heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD alpha; heat shock 105kD beta
 UniProt Protein Name    Heat shock protein 105 kDa
 UniProt Synonym Protein Names   
Antigen NY-CO-25; Heat shock 110 kDa protein
 Protein Family    Heat shock protein
 UniProt Gene Name    HSPH1 [Similar Products]
 UniProt Synonym Gene Names    HSP105; HSP110; KIAA0201 [Similar Products]
 UniProt Entry Name    HS105_HUMAN
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 UniProt Comments for HSPH1    HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function: protein binding; ATP binding; alpha-tubulin binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein
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 Research Articles on HSPH1    1. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSPH1 antibodyPathways associated with anti-HSPH1 antibody
 Reference Product  PubMed Publications
 DNAJB1 antibody  >8 publications with HSPH1 and DNAJB1
 DNAJA1 antibody  >5 publications with HSPH1 and DNAJA1
 HSPA8 antibody  >4 publications with HSPH1 and HSPA8
 HSP90AA1 antibody  >1 publications with HSPH1 and HSP90AA1
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Scavenging By Class F Receptors Pathway antibodies  Scavenging By Class F Receptors Pathway Diagram
Diseases associated with anti-HSPH1 antibodyOrgans/Tissues associated with anti-HSPH1 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >6 publications with HSPH1 and Adenocarcinoma
 Disease Models, Animal Antibodies  >3 publications with HSPH1 and Disease Models, Animal
 Inflammation Antibodies  >3 publications with HSPH1 and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with HSPH1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with HSPH1 and Heart Diseases
 Pancreatic Neoplasms Antibodies  >2 publications with HSPH1 and Pancreatic Neoplasms
 Necrosis Antibodies  >2 publications with HSPH1 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >1 publications with HSPH1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >1 publications with HSPH1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with HSPH1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with HSPH1 and Blood
 Skin Antibodies  >7 publications with HSPH1 and Skin
 Brain Antibodies  >7 publications with HSPH1 and Brain
 Lymph Node Antibodies  >3 publications with HSPH1 and Lymph Node
 Lymph Antibodies  >3 publications with HSPH1 and Lymph
 Testis Antibodies  >3 publications with HSPH1 and Testis
 Liver Antibodies  >2 publications with HSPH1 and Liver
 Intestine Antibodies  >2 publications with HSPH1 and Intestine
 Lung Antibodies  >2 publications with HSPH1 and Lung
 Vascular Antibodies  >2 publications with HSPH1 and Vascular
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