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anti-HSP60 antibody :: Mouse anti-Human, mouse Heat shock protein 60, HSP60 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS355099
Western Blot (WB)
Unit / Price
0.1 mg  /  $275 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heat shock protein 60, HSP60, Monoclonal Antibody

 Also Known As   

Anti-Heat shock protein 60, HSP60 antibody

 Product Synonym Names    Monoclonal Anti- Heat shock protein 60; HSP60
 Product Gene Name   

anti-HSP60 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_003074.8 (8668918..8672578). Location: chromosome: 3
 3D Structure    ModBase 3D Structure for P29197
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    H6-2
 Host    Mouse
 Species Reactivity    Human, mouse
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 Purity/Purification    Protein A or Protein G purified
 Form/Format    Liquid
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 Immunogen    A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of HSP60.
 Storage Buffer    In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.
 Storage Buffer    In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.
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 Preparation and Storage    Store at 4 degree C after thawing (1 week). Aliquot and store at -20 degree C for long term (at least one year). Avoid repeated freeze and thaw cycles
 Other Notes    Small volumes of anti-HSP60 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HSP60 antibody

   Heat shock protein 60 (HSP60) in the matrix of mitochondria is essential for the folding and assembly of newly imported proteins. Hsp60 belongs to a class of structurally related chaperonins found in organelles of endosymbiotic origin and in the bacterial cytosol.1 Members of the chaperonin class include the Escherichia coli, groEL protein and the Rubisco subunit-binding protein of chloroplasts.2 In both prokaryotic and eukaryotic systems, synthesis of these proteins is induced in response to stresses, such as heat shock.3 Under normal physiological conditions, HSP60 is a 60 KD oligomer composed of monomers that form a complex arranged as two stacked heptameric rings.1 HSP60 may be a very useful marker for patients with superficial bladder carcinoma and may be used for predicting disease progression. And low HSP60 expression levels may be usable as a prognostic marker to identify patients for whom local treatment would be insufficient.4 HSP60 also linked to diabetes, cancer and certain types of immunological disorders.
 Applications Tested/Suitable for anti-HSP60 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

 Application Notes for anti-HSP60 antibody    WB (1:5000)
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 Western Blot (WB) of anti-HSP60 antibody    anti-HSP60 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HSP60. It may not necessarily be applicable to this product.
 NCBI GI #    15229559
 NCBI GeneID    821983
 NCBI Accession #    NP_189041.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_113304.4 [Other Products]
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 UniProt Primary Accession #    P29197 [Other Products]
 UniProt Secondary Accession #    Q9LIQ8 [Other Products]
 UniProt Related Accession #    P29197 [Other Products]
 Molecular Weight    61,281 Da
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 NCBI Official Full Name    heat shock protein 60
 NCBI Official Symbol    HSP60 [Similar Products]
 NCBI Official Synonym Symbols   
heat shock protein 60; HEAT SHOCK PROTEIN 60-3B; HSP60; HSP60-3B
[Similar Products]
 NCBI Protein Information    heat shock protein 60
 UniProt Protein Name    Chaperonin CPN60, mitochondrial
 UniProt Synonym Protein Names   
HSP60
 Protein Family    Hydrogenosomal chaperonin
 UniProt Gene Name    CPN60 [Similar Products]
 UniProt Entry Name    CH60A_ARATH
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 NCBI Summary for HSP60    mitochondrial chaperonin HSP. assist in rapid assembly of the oligomeric protein structures in the mitochondria.
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 UniProt Comments for HSP60    Function: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

Subcellular location: Mitochondrion.

Induction: By heat shock.

Sequence similarities: Belongs to the chaperonin (HSP60) family.
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Product References and Citations for anti-HSP60 antibody

   1. Cheng MY, Hartl FU, Horwich AL (November 1990). "The mitochondrial chaperonin hsp60 is required for its own assembly". Nature 348 (6300): 455-8. 2. Cheng, M. Y., Hartl, F.-U., Martin, J., Pollock, R. A., Kalousek, F., Neupert, W., Hallberg, E. M., Hallberg, R. L., Horwich, A. L. Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature 337: 620-625, 1989. 3. Venner, T. J., Singh, B., Gupta, R. S. Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families. DNA Cell Biol. 9: 545-552, 1990. 4. Lebret T, Watson RW, Moliniť V, et al. (September 2003). "Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma". Cancer 98 (5): 970-7.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSP60 antibodyPathways associated with anti-HSP60 antibody
 Reference Product  PubMed Publications
 HSP70 antibody  >770 publications with HSP60 and HSP70
 CPN10 antibody  >14 publications with HSP60 and CPN10
 HSP60-3A antibody  >3 publications with HSP60 and HSP60-3A
 Hsp70b antibody  >3 publications with HSP60 and Hsp70b
 Products by Pathway  Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
Organs/Tissues associated with anti-HSP60 antibody
 Organ/Tissue Name  Pubmed Publications
 Root Antibodies  >6 publications with HSP60 and Root
 Whole Plant Antibodies  >5 publications with HSP60 and Whole Plant
 Flower Antibodies  >1 publications with HSP60 and Flower
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