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anti-HMOX1 antibody :: Mouse Heme Oxygenase-1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190201 anti-HMOX1 antibody
Unit / Price
0.1 mg  /  $450 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heme Oxygenase-1 (HMOX1), Monoclonal Antibody

 Also Known As   

Heme Oxygenase 1 Monoclonal Antibody

 Product Synonym Names    Heme Oxygenase-1
 Product Gene Name   

anti-HMOX1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 22; NC_000022.10 (35777060..35790207). Location: 22q12; 22q13.1
 OMIM    141250
 3D Structure    ModBase 3D Structure for P09601
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    GTS-1
 Host    Mouse
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 Specificity    Heme Oxygenase-1 [Mouse monoclonal antibody to Heme Oxygenase-1]
This antibody reacts with human, rat and mouse heme oxygenase 1. It does not react with rabbit heme oxygenase I or heme oxygenase 2. This antibody will inhibit the activity of human or rat heme oxygenase 1.
 Form/Format    100 ug IgG in 10 mM PBS, pH 7.4, lyophilized.
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 Antigen    Rat heme oxygenase 1.
 Stabilizer    1% BSA
 Preservatives    None
 Dilutions Instructions    Reconstitute in distilled water to the final desired concentration.
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 Preparation and Storage    Lyophilized antibody is stable at 4 degree C for 2 years. Store the reconstituted solution in aliquots at -20 degree C or at 4 degree C for 6 months after the addition of 0.1% sodium azide by the user.
 Other Notes    Small volumes of anti-HMOX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-HMOX1 antibody    Enzyme and Enzyme Inhibitor Antibodies
 Applications Tested/Suitable for anti-HMOX1 antibody   

ELISA, Western Blot, Immunohistochemistry

 Application Notes for anti-HMOX1 antibody    ELISA: 1:10,000 dilution with solid phase antigen.
Western Blot: 5-10 ug/ml.
Immunohistochemistry: 5-10 ug/ml (for use on human frozen or paraffin embedded tissue). Heme oxygenase 1 activity assays.
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NCBI/Uniprot data below describe general gene information for HMOX1. It may not necessarily be applicable to this product.
 NCBI GI #    579973
 NCBI GeneID    3162
 NCBI Accession #    CAA32886.1 [Other Products]
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 UniProt Primary Accession #    P09601 [Other Products]
 UniProt Related Accession #    P09601; Q6FH11; Q96DI8 [Other Products]
 Molecular Weight    32,819 Da [Similar Products]
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 NCBI Official Full Name    heme oxygenase-1
 NCBI Official Synonym Full Names    heme oxygenase (decycling) 1
 NCBI Official Symbol    HMOX1 [Similar Products]
 NCBI Official Synonym Symbols   
HO-1; HSP32; bK286B10
[Similar Products]
 NCBI Protein Information    heme oxygenase 1; OTTHUMP00000198812; heat shock protein, 32-kD
 UniProt Protein Name    Heme oxygenase 1
 UniProt Gene Name    HMOX1 [Similar Products]
 UniProt Synonym Gene Names    HO; HO1 [Similar Products]
 UniProt Entry Name    HMOX1_HUMAN
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 NCBI Summary for HMOX1    Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq]
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 UniProt Comments for HMOX1    HMOX1: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. Expressed at higher levels in renal cancer tissue than in normal tissue. Belongs to the heme oxygenase family.

Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extracellular space; endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; endoplasmic reticulum; nucleolus; caveola; nucleus; cytosol

Molecular Function: signal transducer activity; protein binding; enzyme binding; protein homodimerization activity; metal ion binding; phospholipase D activity; heme binding; heme oxygenase (decyclizing) activity

Biological Process: cell death; response to nicotine; negative regulation of smooth muscle cell proliferation; cellular iron ion homeostasis; negative regulation of mast cell degranulation; positive regulation of smooth muscle cell proliferation; excretion; positive regulation of vasodilation; erythrocyte homeostasis; regulation of transcription factor activity; heme catabolic process; small GTPase mediated signal transduction; regulation of blood pressure; porphyrin metabolic process; negative regulation of mast cell cytokine production; angiogenesis; negative regulation of neuron apoptosis; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; transmembrane transport; healing during inflammatory response; protein homooligomerization; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription factor activity; heme oxidation; cellular response to nutrient; negative regulation of leukocyte migration; regulation of angiogenesis; negative regulation of DNA binding; positive regulation of angiogenesis; iron ion homeostasis; positive regulation of chemokine biosynthetic process; DNA damage response, signal transduction resulting in induction of apoptosis; response to hydrogen peroxide; response to estrogen stimulus; endothelial cell proliferation; response to oxidative stress; smooth muscle hyperplasia

Disease: Heme Oxygenase 1 Deficiency; Pulmonary Disease, Chronic Obstructive
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 Research Articles on HMOX1    1. Heme oxygenase-1 may confer protection from hypoxic pulmonary hypertension by effectively modifying the macrophage activation state in hypoxia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HMOX1 antibodyPathways associated with anti-HMOX1 antibody
 Reference Product  PubMed Publications
 AKT1 antibody  >10 publications with HMOX1 and AKT1
 NOS1 antibody  >9 publications with HMOX1 and NOS1
 POR antibody  >3 publications with HMOX1 and POR
 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Heme Degradation Pathway antibodies  Heme Degradation Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Keap1-Nrf2 Pathway antibodies  Keap1-Nrf2 Pathway Diagram
 Metabolism Of Porphyrins Pathway antibodies  Metabolism Of Porphyrins Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
Diseases associated with anti-HMOX1 antibodyOrgans/Tissues associated with anti-HMOX1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >861 publications with HMOX1 and Cardiovascular Diseases
 Inflammation Antibodies  >845 publications with HMOX1 and Inflammation
 Drug Toxicity Antibodies  >620 publications with HMOX1 and Drug Toxicity
 Neoplasms Antibodies  >333 publications with HMOX1 and Neoplasms
 Lung Diseases Antibodies  >280 publications with HMOX1 and Lung Diseases
 Liver Diseases Antibodies  >275 publications with HMOX1 and Liver Diseases
 Kidney Diseases Antibodies  >224 publications with HMOX1 and Kidney Diseases
 Lung Injury Antibodies  >207 publications with HMOX1 and Lung Injury
 Myocardial Ischemia Antibodies  >184 publications with HMOX1 and Myocardial Ischemia
 Atherosclerosis Antibodies  >168 publications with HMOX1 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1312 publications with HMOX1 and Blood
 Vascular Antibodies  >1030 publications with HMOX1 and Vascular
 Liver Antibodies  >763 publications with HMOX1 and Liver
 Brain Antibodies  >570 publications with HMOX1 and Brain
 Kidney Antibodies  >540 publications with HMOX1 and Kidney
 Muscle Antibodies  >536 publications with HMOX1 and Muscle
 Lung Antibodies  >508 publications with HMOX1 and Lung
 Heart Antibodies  >417 publications with HMOX1 and Heart
 Skin Antibodies  >149 publications with HMOX1 and Skin
 Intestine Antibodies  >129 publications with HMOX1 and Intestine
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