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anti-HBB antibody :: Mouse Hemoglobin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS530164 anti-HBB antibody
Unit / Price
1 mg  /  $415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hemoglobin (HBB), Monoclonal Antibody

 Also Known As   

Hemoglobin antibody

 Product Synonym Names    Monoclonal Hemoglobin; Anti-Hemoglobin; Hemoglobin (Whole)
 Product Gene Name   

anti-HBB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q0Z944
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4720000
 Host    Mouse
 Species Reactivity    Human hemoglobin
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 Form/Format    PBS, pH 7.4, with 0.09% NaN3
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 Biological Significance    Hemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates (except the fish family Channichthyidae) and the tissues of some invertebrates. Hemoglobin in the blood is what transports oxygen from the lungs or gills to the rest of the body (i.e. the tissues) where it releases the oxygen for cell use, and collects carbon dioxide to bring it back to the lungs. In mammals the protein makes up about 97% of the red blood cells' dry content, and around 35% of the total content (including water).Hemoglobin has an oxygen binding capacity of 1.34 ml O2 per gram of hemoglobin, which increases the total blood oxygen capacity seventyfold.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Hemoglobin antibody was raised in mouse using human hemoglobin as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-HBB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HBB antibody

   Mouse monoclonal Hemoglobin antibody
 Product Categories/Family for anti-HBB antibody    Nutrition & Metabolism
 Applications Tested/Suitable for anti-HBB antibody   

User optimized

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NCBI/Uniprot data below describe general gene information for HBB. It may not necessarily be applicable to this product.
 NCBI GI #    109893891
 NCBI GeneID    3043
 NCBI Accession #    ABG47031.1 [Other Products]
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 UniProt Primary Accession #    Q0Z944 [Other Products]
 UniProt Related Accession #    P68871 [Other Products]
 Molecular Weight    11,504 Da [Similar Products]
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 NCBI Official Full Name    hemoglobin, partial
 NCBI Official Synonym Full Names    hemoglobin, beta
 NCBI Official Symbol    HBB [Similar Products]
 NCBI Official Synonym Symbols   
CD113t-C; beta-globin
[Similar Products]
 NCBI Protein Information    hemoglobin subunit beta
 UniProt Protein Name    Beta globin
 UniProt Synonym Protein Names   
Beta globin
 Protein Family    Hemoglobin
 UniProt Gene Name    HBB [Similar Products]
 UniProt Entry Name    Q0Z944_HUMAN
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 NCBI Summary for HBB    The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HBB    HBB: Involved in oxygen transport from the lung to the various peripheral tissues. Defects in HBB may be a cause of Heinz body anemias (HEIBAN). This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency. Defects in HBB are the cause of beta-thalassemia (B-THAL). A form of thalassemia. Thalassemias are common monogenic diseases occurring mostly in Mediterranean and Southeast Asian populations. The hallmark of beta-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. Absence of beta chain causes beta(0)-thalassemia, while reduced amounts of detectable beta globin causes beta(+)-thalassemia. In the severe forms of beta-thalassemia, the excess alpha globin chains accumulate in the developing erythroid precursors in the marrow. Their deposition leads to a vast increase in erythroid apoptosis that in turn causes ineffective erythropoiesis and severe microcytic hypochromic anemia. Clinically, beta-thalassemia is divided into thalassemia major which is transfusion dependent, thalassemia intermedia (of intermediate severity), and thalassemia minor that is asymptomatic. Defects in HBB are the cause of sickle cell anemia (SKCA); also known as sickle cell disease. Sickle cell anemia is characterized by abnormally shaped red cells resulting in chronic anemia and periodic episodes of pain, serious infections and damage to vital organs. Normal red blood cells are round and flexible and flow easily through blood vessels, but in sickle cell anemia, the abnormal hemoglobin (called Hb S) causes red blood cells to become stiff. They are C-shaped and resembles a sickle. These stiffer red blood cells can led to microvascular occlusion thus cutting off the blood supply to nearby tissues. Defects in HBB are the cause of beta-thalassemia dominant inclusion body type (B-THALIB). An autosomal dominant form of beta thalassemia characterized by moderate anemia, lifelong jaundice, cholelithiasis and splenomegaly, marked morphologic changes in the red cells, erythroid hyperplasia of the bone marrow with increased numbers of multinucleate red cell precursors, and the presence of large inclusion bodies in the normoblasts, both in the marrow and in the peripheral blood after splenectomy. Belongs to the globin family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: hemoglobin complex; extracellular region; cytosol

Molecular Function: haptoglobin binding; protein binding; peroxidase activity; hemoglobin binding; iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: receptor-mediated endocytosis; positive regulation of nitric oxide biosynthetic process; nitric oxide transport; response to hydrogen peroxide; protein heterooligomerization; hydrogen peroxide catabolic process; bicarbonate transport; oxygen transport; regulation of blood pressure; regulation of blood vessel size; blood coagulation

Disease: Fetal Hemoglobin Quantitative Trait Locus 1; Beta-thalassemia; Sickle Cell Anemia; Heinz Body Anemias; Beta-thalassemia, Dominant Inclusion Body Type; Malaria, Susceptibility To; Alpha-thalassemia
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 Research Articles on HBB    1. Molecular defect in the alpha-globin and beta-globin genes, and in the KLF1 gene were found in the borderline hemoglobin A2 Chinese individuals.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HBB antibodyPathways associated with anti-HBB antibody
 Reference Product  PubMed Publications
 HBA2 antibody  >30 publications with HBB and HBA2
 HBA1 antibody  >21 publications with HBB and HBA1
 HBG2 antibody  >16 publications with HBB and HBG2
 KLF1 antibody  >9 publications with HBB and KLF1
 HPX antibody  >4 publications with HBB and HPX
 HBZ antibody  >3 publications with HBB and HBZ
 AQP1 antibody  >1 publications with HBB and AQP1
 Products by Pathway  Pathway Diagram
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 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway antibodies  Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway Diagram
 Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway antibodies  Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
Organs/Tissues associated with anti-HBB antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >259 publications with HBB and Blood
 Liver Antibodies  >71 publications with HBB and Liver
 Brain Antibodies  >30 publications with HBB and Brain
 Bone Antibodies  >30 publications with HBB and Bone
 Kidney Antibodies  >23 publications with HBB and Kidney
 Bone Marrow Antibodies  >21 publications with HBB and Bone Marrow
 Muscle Antibodies  >20 publications with HBB and Muscle
 Eye Antibodies  >19 publications with HBB and Eye
 Heart Antibodies  >18 publications with HBB and Heart
 Lung Antibodies  >14 publications with HBB and Lung
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