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anti-HSPG2 antibody :: Rat Heparan Sulfate Proteoglycan, Domain 4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS600265 anti-HSPG2 antibody
Unit / Price
0.5 mL  /  $665 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heparan Sulfate Proteoglycan, Domain 4 (HSPG2), Monoclonal Antibody

 Also Known As   

Heparan Sulfate Proteoglycan, Domain 4 (Perlecan, HSPG)

 Product Synonym Names    Anti -Heparan Sulfate Proteoglycan, Domain 4 (Perlecan, HSPG)
 Product Gene Name   

anti-HSPG2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (22148737..22263750, complement). Location: 1p36.1-p34
 OMIM    142461
 3D Structure    ModBase 3D Structure for P98160
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 Clonality    Monoclonal
 Isotype    IgG2a,k
 Clone Number    0.N.325 (A7L6)
 Host    Rat
 Species Reactivity    Bovine, Human, Mouse, Porcine
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 Specificity    Recognizes mouse Heparan Sulfate Proteoglycan. Does not crossreact with laminin, fibronectin or dermatran sulfate proteoglycan. Species crossreactivity: Human, bovine, porcine
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See H1890-92X.
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 Immunogen    Mouse EHS laminin preparation. Cellular Localization: Basement membrane
 Positive Control    Tonsil
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-HSPG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HSPG2 antibody

   Perlecan is a major heparan sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth facors, perlecan hs been stronglyimplicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor. Suppression of perlican causes substantial inhibition of neoplastic growth and neovasacularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogaenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
 Product Categories/Family for anti-HSPG2 antibody    Antibodies; Abs to Carbohydrates, Glycoproteins
 Applications Tested/Suitable for anti-HSPG2 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-HSPG2 antibody    Suitable for use in Immunofluorescence and Immunohistochemistry. Not suitable for use in Western Blot.
Dilution: Immunohistochemistry (Frozen and acid-alcohol fixed, paraffin embedded sections): 1-2ug/ml for 30 minutes at RT. Staining of acid-alcohol-fixed tissues requires antigen unmasking with 15,000u/ml of bovine testicular hyaluronidase in PBS, pH 7.4 for 30 minutes at 37 degree C
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NCBI/Uniprot data below describe general gene information for HSPG2. It may not necessarily be applicable to this product.
 NCBI GI #    11602963
 NCBI GeneID    3339
 NCBI Accession #    CAC18534.1 [Other Products]
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 UniProt Primary Accession #    P98160 [Other Products]
 UniProt Secondary Accession #    Q16287; Q5SZI3; Q9H3V5 [Other Products]
 UniProt Related Accession #    P98160 [Other Products]
 Molecular Weight    468,830 Da [Similar Products]
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 NCBI Official Full Name    heparan sulfate proteoglycan perlecan
 NCBI Official Synonym Full Names    heparan sulfate proteoglycan 2
 NCBI Official Symbol    HSPG2 [Similar Products]
 NCBI Official Synonym Symbols   
PLC; SJA; SJS; HSPG; SJS1; PRCAN
[Similar Products]
 NCBI Protein Information    basement membrane-specific heparan sulfate proteoglycan core protein; perlecan proteoglycan; endorepellin (domain V region)
 UniProt Protein Name    Basement membrane-specific heparan sulfate proteoglycan core protein
 UniProt Synonym Protein Names   
Perlecan
 Protein Family    Small heat shock protein
 UniProt Gene Name    HSPG2 [Similar Products]
 UniProt Synonym Gene Names    HSPG; PLC [Similar Products]
 UniProt Entry Name    PGBM_HUMAN
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 NCBI Summary for HSPG2    This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010]
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 UniProt Comments for HSPG2    HSPG2: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Defects in HSPG2 are the cause of Schwartz-Jampel syndrome (SJS1); a rare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses. Defects in HSPG2 are the cause of dyssegmental dysplasia Silverman-Handmaker type (DDSH). The dyssegmental dysplasias are rare, autosomal recessive skeletal dysplasias with anisospondyly and micromelia. There are two recognized types: the severe, lethal DDSH and the milder Rolland-Desbuquois form. Individuals with DDSH also have a flat face, micrognathia, cleft palate and reduced joint mobility, and frequently have an encephalocoele. The endochondral growth plate is short, the calcospherites (which are spherical calcium-phosphorus crystals produced by hypertrophic chondrocytes) are unfused, and there is mucoid degeneration of the resting cartilage.

Protein type: Cell adhesion; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 1p36.1-p34

Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; focal adhesion; Golgi lumen; plasma membrane; extracellular region; basal lamina

Molecular Function: protein C-terminus binding; protein binding; metal ion binding

Biological Process: cardiac muscle development; phototransduction, visible light; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; lipoprotein metabolic process; pathogenesis; embryonic skeletal morphogenesis; chondroitin sulfate metabolic process; extracellular matrix disassembly; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; protein localization; carbohydrate metabolic process; chondrocyte differentiation; angiogenesis; brain development; retinoid metabolic process; endochondral ossification

Disease: Schwartz-jampel Syndrome, Type 1; Dyssegmental Dysplasia, Silverman-handmaker Type
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 Research Articles on HSPG2    1. No association has been found between polymorphisms of rs251124 and rs3767137 loci of CSPG2 and HSPG2 genes and intracranial aneurysm in the selected population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSPG2 antibodyPathways associated with anti-HSPG2 antibody
 Reference Product  PubMed Publications
 SDC2 antibody  >2 publications with HSPG2 and SDC2
 HPSE antibody  >1 publications with HSPG2 and HPSE
 BGN antibody  >1 publications with HSPG2 and BGN
 APP antibody  >1 publications with HSPG2 and APP
 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
Diseases associated with anti-HSPG2 antibodyOrgans/Tissues associated with anti-HSPG2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >17 publications with HSPG2 and Nervous System Diseases
 Osteochondrodysplasias Antibodies  >9 publications with HSPG2 and Osteochondrodysplasias
 Mental Disorders Antibodies  >9 publications with HSPG2 and Mental Disorders
 Cardiovascular Diseases Antibodies  >8 publications with HSPG2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >6 publications with HSPG2 and Disease Models, Animal
 Movement Disorders Antibodies  >5 publications with HSPG2 and Movement Disorders
 Kidney Diseases Antibodies  >5 publications with HSPG2 and Kidney Diseases
 Dementia Antibodies  >5 publications with HSPG2 and Dementia
 Alzheimer Disease Antibodies  >5 publications with HSPG2 and Alzheimer Disease
 Dyssegmental dysplasia Antibodies  >5 publications with HSPG2 and Dyssegmental dysplasia
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >10 publications with HSPG2 and Bone
 Blood Antibodies  >9 publications with HSPG2 and Blood
 Muscle Antibodies  >8 publications with HSPG2 and Muscle
 Vascular Antibodies  >6 publications with HSPG2 and Vascular
 Embryonic Tissue Antibodies  >6 publications with HSPG2 and Embryonic Tissue
 Connective Tissue Antibodies  >5 publications with HSPG2 and Connective Tissue
 Eye Antibodies  >4 publications with HSPG2 and Eye
 Brain Antibodies  >4 publications with HSPG2 and Brain
 Ovary Antibodies  >4 publications with HSPG2 and Ovary
 Kidney Antibodies  >4 publications with HSPG2 and Kidney
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