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anti-HPA antibody :: Mouse anti-Human Heparanase (HPA) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2090630
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $175 +1 FREE 8GB USB
0.2 mg  /  $225 +1 FREE 8GB USB
1 mg  /  $510 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heparanase (HPA), Monoclonal Antibody

 Also Known As   

Monoclonal Antibody to Heparanase (HPA)

 Product Synonym Names    HPSE; HPR1; HPSE1; HSE1; Endo-glucoronidase;
 Product Gene Name   

anti-HPA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF152376 mRNA
 3D Structure    ModBase 3D Structure for Q9Y251
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 Clonality    Monoclonal
 Isotype    IgG2a Lambda
 Clone Number    C1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against HPA. It has been selected for its ability to recognize HPA in immunohistochemical staining and western blotting.
 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Liquid
 Concentration    1mg/mL (lot specific)
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 Immunogen    Recombinant Heparanase (HPA)
 Buffer Formulation    0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-HPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HPA antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

 Application Notes for anti-HPA antibody    Western Blot: 0.5-5ug/mL
Immunohistochemistry: 5-30ug/mL
Immunocytochemistry: 5-30ug/mL
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 Western Blot (WB) of anti-HPA antibody    (Western Blot; Sample: Human Jurkat cell lysate; Primary Ab: 2ug/ml Mouse Anti-Human HPA Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody )
anti-HPA antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-HPA antibody    (Figure. Western Blot; Sample: Recombinant HPA, Human.)
anti-HPA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HPA. It may not necessarily be applicable to this product.
 NCBI GI #    148746204
 NCBI GeneID    10855
 NCBI Accession #    NP_001092010.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001098540.2 [Other Products]
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 UniProt Primary Accession #    Q9Y251 [Other Products]
 UniProt Secondary Accession #    Q53GE5; Q9UL39; A9JIG7; C7F7I3; C7F7I4; E9PCA9; E9PGR1 [Other Products]
 UniProt Related Accession #    Q9Y251 [Other Products]
 Molecular Weight    42,791 Da
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 NCBI Official Full Name    heparanase isoform 1 preproprotein
 NCBI Official Synonym Full Names    heparanase
 NCBI Official Symbol    HPSE [Similar Products]
 NCBI Official Synonym Symbols   
HPA; HPA1; HPR1; HSE1; HPSE1
[Similar Products]
 NCBI Protein Information    heparanase
 UniProt Protein Name    Heparanase
 UniProt Synonym Protein Names   
Endo-glucoronidase; Heparanase-1; Hpa1
 UniProt Gene Name    HPSE [Similar Products]
 UniProt Synonym Gene Names    HEP; HPA; HPA1; HPR1; HPSE1; HSE1; Hpa1 [Similar Products]
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 NCBI Summary for HPA    Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for HPA    HPSE: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up- regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis. Belongs to the glycosyl hydrolase 79 family.

Protein type: EC 3.2.1.166; Extracellular matrix; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21.23

Cellular Component: extracellular region; intracellular membrane-bound organelle; lysosomal lumen; lysosomal membrane; lysosome; membrane raft; nucleoplasm; nucleus; proteinaceous extracellular matrix

Molecular Function: beta-glucuronidase activity; heparanase activity; protein binding; protein dimerization activity; syndecan binding

Biological Process: angiogenesis involved in wound healing; cell-matrix adhesion; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process; neutrophil degranulation; positive regulation of blood coagulation; positive regulation of hair follicle development; positive regulation of osteoblast proliferation; positive regulation of protein kinase B signaling; proteoglycan metabolic process; regulation of hair follicle development
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 Research Articles on HPA    1. Data demonstrate that the mesenchymal features induced by HPSE in MM cells contribute to enhanced tumor cell motility and bone-dissemination.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HPA antibodyPathways associated with anti-HPA antibody
 Reference Product  PubMed Publications
 SDC1 antibody  >2 publications with HPA and SDC1
 GPC3 antibody  >1 publications with HPA and GPC3
 HSPG2 antibody  >1 publications with HPA and HSPG2
 Products by Pathway  Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Defective PAPSS2 Causes SEMD-PA Pathway antibodies  Defective PAPSS2 Causes SEMD-PA Pathway Diagram
Diseases associated with anti-HPA antibodyOrgans/Tissues associated with anti-HPA antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >23 publications with HPA and Neoplasm Metastasis
 Inflammation Antibodies  >18 publications with HPA and Inflammation
 Melanoma Antibodies  >13 publications with HPA and Melanoma
 Neoplasm Invasiveness Antibodies  >12 publications with HPA and Neoplasm Invasiveness
 Lung Neoplasms Antibodies  >9 publications with HPA and Lung Neoplasms
 Breast Neoplasms Antibodies  >9 publications with HPA and Breast Neoplasms
 Disease Models, Animal Antibodies  >8 publications with HPA and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >6 publications with HPA and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >5 publications with HPA and Liver Neoplasms
 Kidney Diseases Antibodies  >4 publications with HPA and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >20 publications with HPA and Vascular
 Bone Antibodies  >13 publications with HPA and Bone
 Lung Antibodies  >12 publications with HPA and Lung
 Brain Antibodies  >12 publications with HPA and Brain
 Kidney Antibodies  >9 publications with HPA and Kidney
 Lymph Node Antibodies  >9 publications with HPA and Lymph Node
 Placenta Antibodies  >7 publications with HPA and Placenta
 Nerve Antibodies  >4 publications with HPA and Nerve
 Uterus Antibodies  >3 publications with HPA and Uterus
 Stomach Antibodies  >3 publications with HPA and Stomach
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