AAP44001.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
hepatocyte growth factor activator inhibitor 1B
NCBI Official Synonym Full Names
serine peptidase inhibitor, Kunitz type 1
NCBI Protein Information
kunitz-type protease inhibitor 1; HAI-1; serine protease inhibitor, Kunitz type 1; hepatocyte growth factor activator inhibitor type 1
UniProt Protein Name
Kunitz-type protease inhibitor 1
UniProt Synonym Protein Names
Hepatocyte growth factor activator inhibitor type 1
UniProt Synonym Gene Names
UniProt Entry Name
SPIT1_HUMAN
NCBI Summary for SPINT1
The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for SPINT1
SPINT1: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: extracellular space; membrane; extracellular region
Molecular Function: serine-type endopeptidase inhibitor activity
Biological Process: extracellular matrix organization and biogenesis
Research Articles on SPINT1
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Products associated with anti-SPINT1 antibody
Pathways associated with anti-SPINT1 antibody
Diseases associated with anti-SPINT1 antibody
Organs/Tissues associated with anti-SPINT1 antibody
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