NP_000180.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
hexokinase-2
NCBI Official Synonym Full Names
hexokinase 2
NCBI Protein Information
hexokinase-2; HK II; OTTHUMP00000160433; OTTHUMP00000202738; hexokinase type II; hexokinase-2, muscle; muscle form hexokinase
UniProt Protein Name
Hexokinase-2
UniProt Synonym Protein Names
Hexokinase type II; HK II; Muscle form hexokinase
UniProt Entry Name
HXK2_HUMAN
NCBI Summary for HK2
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq]
UniProt Comments for HK2
HK2: a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). The predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). Genetic variations of HK2 do not appear to contribute to NIDDM.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Mitochondrial; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: mitochondrial outer membrane; membrane; cytosol
Molecular Function: hexokinase activity; mannokinase activity; fructokinase activity; glucokinase activity; ATP binding; glucose binding
Biological Process: lactation; apoptotic mitochondrial changes; glycolysis; hexose transport; carbohydrate metabolic process; glucose 6-phosphate metabolic process; carbohydrate phosphorylation; cell glucose homeostasis; glucose metabolic process; regulation of glucose import; pathogenesis; glucose transport; transmembrane transport
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Products associated with anti-HK2 antibody
Pathways associated with anti-HK2 antibody
Diseases associated with anti-HK2 antibody
Organs/Tissues associated with anti-HK2 antibody
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