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anti-HIST1H3A antibody :: Histone H3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8241534
Unit / Price
0.03 mL  /  $165 +1 FREE 8GB USB
0.1 mL  /  $245 +1 FREE 8GB USB
0.2 mL  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Histone H3 (HIST1H3A), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Histone H3 (TriMethyl K36) Antibody

 Product Synonym Names    HIST1H3A; H3FA; HIST1H3B; H3FL; HIST1H3C; H3FC; HIST1H3D; H3FB; HIST1H3E; H3FD; HIST1H3F; H3FI; HIST1H3G; H3FH; HIST1H3H; H3FK; HIST1H3I; H3FF; HIST1H3J; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; HIST2H3A; HIST2H3C; H3F2; H3FM; HIST2H3D; Histone H3.2; Histone H3/m; Histone H3/o; H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B; Histone H3.3
 Product Gene Name   

anti-HIST1H3A antibody

[Similar Products]
 Product Synonym Gene Name    HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST2H3A; HIST2H3C; HIST2H3D; H3F3A; H3F3B [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602810
 3D Structure    ModBase 3D Structure for P68431
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 Clonality    Monoclonal
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes endogenous levels of Histone H3 (TriMethyl K36) protein.
 Form/Format    Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
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 Source    Mouse
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence of human Histone H3. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4C. Upon delivery aliquot and store at -20C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-HIST1H3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HIST1H3A antibody

   Mouse monoclonal to Histone H3 (TriMethyl K36)
 Applications Tested/Suitable for anti-HIST1H3A antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-HIST1H3A antibody    Western Blot: (1/1000 - 1/3000)

Immunohistochemistry: (1/200 - 1/500)
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 Western Blot (WB) of anti-HIST1H3A antibody    Western blot analysis of Histone H3 (TriMethyl K36) expression in Hela (A) whole cell lysates.
anti-HIST1H3A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HIST1H3A antibody    Immunohistochemical analysis of Histone H3 (TriMethyl K36) staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-HIST1H3A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HIST1H3A. It may not necessarily be applicable to this product.
 NCBI GI #    55977055
 NCBI GeneID    8350
 NCBI Accession #    P68431.2 [Other Products]
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 UniProt Primary Accession #    P68431 [Other Products]
 UniProt Secondary Accession #    P02295; P02296; P16106; Q6ISV8; Q6NWP8; Q6NWP9; Q6NXU4; Q71DJ3; Q93081; A0PJT7; A5PLR1 [Other Products]
 UniProt Related Accession #    P68431 [Other Products]
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 NCBI Official Full Name    Histone H3.1
 NCBI Official Synonym Full Names    histone cluster 1, H3j
 NCBI Official Symbol    HIST1H3J [Similar Products]
 NCBI Official Synonym Symbols   
H3/j; H3FJ
[Similar Products]
 NCBI Protein Information    histone H3.1
 UniProt Protein Name    Histone H3.1
 UniProt Synonym Protein Names   
Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l
 Protein Family    Histone
 UniProt Gene Name    HIST1H3A [Similar Products]
 UniProt Synonym Gene Names    H3FA [Similar Products]
 UniProt Entry Name    H31_HUMAN
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 NCBI Summary for HIST1H3A    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
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 UniProt Comments for HIST1H3A    H3: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p22.2

Cellular Component: extracellular region; membrane; nuclear chromosome; nuclear chromosome, telomeric region; nucleoplasm; nucleosome; nucleus; protein complex

Molecular Function: DNA binding; histone binding; protein binding; protein heterodimerization activity

Biological Process: blood coagulation; cellular protein metabolic process; chromatin silencing at rDNA; DNA methylation on cytosine; DNA replication-dependent nucleosome assembly; establishment and/or maintenance of chromatin architecture; gene expression; negative regulation of gene expression, epigenetic; nucleosome assembly; positive regulation of defense response to virus by host; positive regulation of gene expression, epigenetic; protein heterotetramerization; regulation of gene expression, epigenetic; RNA-mediated gene silencing; small GTPase mediated signal transduction; telomere organization and biogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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