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anti-HOMER1 antibody :: Mouse anti-Human Homer 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS607905 anti-HOMER1 antibody
Unit / Price
0.1 mL  /  $510 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Homer 1 (HOMER1), Monoclonal Antibody

 Also Known As   

Homer 1

 Product Synonym Names    Anti -Homer 1
 Product Gene Name   

anti-HOMER1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (78669647..78809659, complement). Location: 5q14.2
 OMIM    604798
 3D Structure    ModBase 3D Structure for Q86YM7
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    9k1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human Homer1 (Homer protein homolog 1).
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
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 Immunogen    Recombinant human Homer1 (1-354aa) purified from E. coli
 Hybridoma    Mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Homer1 protein.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-HOMER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HOMER1 antibody

   Homer1 (Homer protein homolog 1) belongs to Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The Homer1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs).
 Product Categories/Family for anti-HOMER1 antibody    Antibodies; Abs to Neuroscience
 Applications Tested/Suitable for anti-HOMER1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-HOMER1 antibody    Suitable for use in ELISA, Western Blotting.
Dilution: Western Blotting: 1:1000-1:2000
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NCBI/Uniprot data below describe general gene information for HOMER1. It may not necessarily be applicable to this product.
 NCBI GI #    4759198
 NCBI GeneID    9456
 NCBI Accession #    NP_004263.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004272.4 [Other Products]
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 UniProt Primary Accession #    Q86YM7 [Other Products]
 UniProt Secondary Accession #    O96003; Q86YM5; B2R688 [Other Products]
 UniProt Related Accession #    Q86YM7 [Other Products]
 Molecular Weight    40,277 Da [Similar Products]
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 NCBI Official Full Name    homer protein homolog 1 isoform 1
 NCBI Official Synonym Full Names    homer homolog 1 (Drosophila)
 NCBI Official Symbol    HOMER1 [Similar Products]
 NCBI Official Synonym Symbols   
HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C
[Similar Products]
 NCBI Protein Information    homer protein homolog 1; homer-1; homer, neuronal immediate early gene, 1
 UniProt Protein Name    Homer protein homolog 1
 Protein Family    Homer protein
 UniProt Gene Name    HOMER1 [Similar Products]
 UniProt Synonym Gene Names    SYN47; Homer-1 [Similar Products]
 UniProt Entry Name    HOME1_HUMAN
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 NCBI Summary for HOMER1    This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HOMER1    HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q14.2

Cellular Component: postsynaptic membrane; costamere; cell soma; apical part of cell; axon; excitatory synapse; dendritic shaft; Z disc; cell junction

Molecular Function: identical protein binding; metabotropic glutatmate receptor binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding; protein complex scaffold

Biological Process: skeletal muscle contraction; circadian rhythm; response to nicotine; synaptic transmission; positive regulation of signal transduction; chemical homeostasis within a tissue; behavioral response to cocaine; metabotropic glutamate receptor, phospholipase C activating pathway; skeletal muscle fiber development; response to calcium ion; positive regulation of calcium ion transport
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 Research Articles on HOMER1    1. The uncoupling of synaptic protein homer 1c from target proteins activates store-operated calcium entry in a neurotransmitter-like manner in human neuroblastoma cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HOMER1 antibodyPathways associated with anti-HOMER1 antibody
 Reference Product  PubMed Publications
 RYR1 antibody  >4 publications with HOMER1 and RYR1
 SHANK1 antibody  >2 publications with HOMER1 and SHANK1
 GRM5 antibody  >2 publications with HOMER1 and GRM5
 Products by Pathway  Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
Diseases associated with anti-HOMER1 antibodyOrgans/Tissues associated with anti-HOMER1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >12 publications with HOMER1 and Nervous System Diseases
 Pain Antibodies  >8 publications with HOMER1 and Pain
 Brain Diseases Antibodies  >5 publications with HOMER1 and Brain Diseases
 Cocaine-Related Disorders Antibodies  >4 publications with HOMER1 and Cocaine-Related Disorders
 Hyperalgesia Antibodies  >3 publications with HOMER1 and Hyperalgesia
 Weight Loss Antibodies  >2 publications with HOMER1 and Weight Loss
 Movement Disorders Antibodies  >2 publications with HOMER1 and Movement Disorders
 Cognition Disorders Antibodies  >2 publications with HOMER1 and Cognition Disorders
 Cardiovascular Diseases Antibodies  >2 publications with HOMER1 and Cardiovascular Diseases
 Abnormalities, Drug-Induced Antibodies  >2 publications with HOMER1 and Abnormalities, Drug-Induced
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >44 publications with HOMER1 and Brain
 Nerve Antibodies  >15 publications with HOMER1 and Nerve
 Muscle Antibodies  >9 publications with HOMER1 and Muscle
 Blood Antibodies  >2 publications with HOMER1 and Blood
 Heart Antibodies  >2 publications with HOMER1 and Heart
 Eye Antibodies  >2 publications with HOMER1 and Eye
 Adrenal Gland Antibodies  >1 publications with HOMER1 and Adrenal Gland
 Kidney Antibodies  >1 publications with HOMER1 and Kidney
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