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anti-Hsp90 alpha antibody :: Mouse Hsp90 alpha Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190539 anti-Hsp90 alpha antibody
Unit / Price
0.1 mg  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hsp90 alpha, Monoclonal Antibody

 Also Known As   

Anti-Hsp90 alpha Monoclonal Antibody

 Product Gene Name   

anti-Hsp90 alpha antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (102547075..102606086, complement). Location: 14q32.33
 OMIM    140571
 3D Structure    ModBase 3D Structure for P07900
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2G5.G3
 Host    Mouse
 Species Reactivity    Human, mouse, rat
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 Specificity    Hsp90 alpha
This antibody recognizes human, mouse, and rat Hsp90alpha. Other species have not been tested. It does not crossreact with Hsp90beta in ELISA.
 Form/Format    100ug Protein G-purified antibody in PBS, pH 7.4.
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 Antigen    Human Hsp90 alpha
 Preservative    None.
 Dilution Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-Hsp90 alpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Hsp90 alpha antibody

   Hsp90 is an abundantly and ubiquitously expressed heat shock protein found in all eukaryotic cells. It exists in two principal forms, alpha and beta, which share 85% sequence homology. Both forms are expressed in the cytosol. Hsp90alpha exists primarily as a homodimer while Hsp90beta exists mainly as a monomer. Hsp90 plays a role in folding, assembly, maturation, and stabilization of specific proteins as a key component of a chaperone complex. Most of the Hsp90-regulated proteins that have been identified are involved in cell signaling; kinases, v-Src, Wee1, c-Raf, and p53 are some examples. When bound to ATP, Hsp90 interacts with cochaperones Cdc37, p23, and various immunophilin-like proteins to form complexes that stabilize and protect target proteins from proteasomal degradation.
 Applications Tested/Suitable for anti-Hsp90 alpha antibody   

ELISA; Immunoblot; Immunohistochemistry; Immunocytochemistry

 Application Notes for anti-Hsp90 alpha antibody    Immunoblotting: use at 0.5-1ug/ml. A band of ~90 kDa is detected. ELISA Immunohistochemistry/ Immunocytochemistry Imunoprecipitation. User should determine optimal concentrations for their application. Positive control: HeLa cell lysate.
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NCBI/Uniprot data below describe general gene information for Hsp90 alpha. It may not necessarily be applicable to this product.
 NCBI GI #    154146191
 NCBI GeneID    3320
 NCBI Accession #    NP_005339.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005348.3 [Other Products]
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 UniProt Primary Accession #    P07900 [Other Products]
 UniProt Secondary Accession #    Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5; A8K500; B3KPJ9 [Other Products]
 UniProt Related Accession #    O75322; P07900; Q2VPJ6; Q86SX1; Q86U12; Q8TBA7; Q96HX7 [Other Products]
 Molecular Weight    84,660 Da
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 NCBI Official Full Name    heat shock protein HSP 90-alpha isoform 2
 NCBI Official Synonym Full Names    heat shock protein 90kDa alpha (cytosolic), class A member 1
 NCBI Official Symbol    HSP90AA1 [Similar Products]
 NCBI Official Synonym Symbols   
HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4; FLJ31884
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-alpha; HSP 86; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kDa protein 1, alpha; renal carcinoma antigen NY-REN-38; heat shock 90kD protein, alpha-like 4; heat shock 90kD protein 1, alpha-like 4
 UniProt Protein Name    Heat shock protein HSP 90-alpha
 UniProt Synonym Protein Names   
Heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38
 UniProt Gene Name    HSP90AA1 [Similar Products]
 UniProt Synonym Gene Names    HSP90A; HSPC1; HSPCA [Similar Products]
 UniProt Entry Name    HS90A_HUMAN
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 NCBI Summary for Hsp90 alpha    HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]
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 UniProt Comments for Hsp90 alpha    HSP90A: a molecular chaperone of the heat shock protein 90 family. Has ATPase activity. Known to interact with a wide variety of proteins including steroid hormone receptors, neuropeptide Y, FKBP51/54, and FKBP52. G protein-coupled receptor kinases are stabilized by interacting with HSP 90. Hsp70 and Hsp90 promote tau solubility and tau binding to microtubules, reducing insoluble tau phosphorylation of tau.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; extracellular region; plasma membrane; melanosome; nucleus; cytosol

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; TPR domain binding; ATPase activity; unfolded protein binding; nitric-oxide synthase regulator activity; nucleotide binding; ATP binding

Biological Process: axon guidance; receptor-mediated endocytosis; positive regulation of nitric oxide biosynthetic process; organelle organization and biogenesis; signal transduction; nitric oxide metabolic process; protein import into mitochondrial outer membrane; response to unfolded protein; mitochondrial transport; innate immune response; protein refolding; mitotic cell cycle; regulation of nitric-oxide synthase activity; chaperone-mediated protein complex assembly; vascular endothelial growth factor receptor signaling pathway; G2/M transition of mitotic cell cycle
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 Research Articles on Hsp90 alpha    1. abrogation of the chaperone activity of Hsp90 affects P-body formation and the integrity of stress granules.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Hsp90 alpha antibodyPathways associated with anti-Hsp90 alpha antibody
 Reference Product  PubMed Publications
 STIP1 antibody  >2 publications with Hsp90 alpha and STIP1
 ST13 antibody  >1 publications with Hsp90 alpha and ST13
 PTGES3 antibody  >1 publications with Hsp90 alpha and PTGES3
 NR3C1 antibody  >1 publications with Hsp90 alpha and NR3C1
 MYC antibody  >1 publications with Hsp90 alpha and MYC
 AKT1 antibody  >1 publications with Hsp90 alpha and AKT1
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 EBV LMP1 Signaling Pathway antibodies  EBV LMP1 Signaling Pathway Diagram
 ErbB Receptor Signaling Network Pathway antibodies  ErbB Receptor Signaling Network Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
Diseases associated with anti-Hsp90 alpha antibodyOrgans/Tissues associated with anti-Hsp90 alpha antibody
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >3 publications with Hsp90 alpha and Neurodegenerative Diseases
 Nervous System Diseases Antibodies  >3 publications with Hsp90 alpha and Nervous System Diseases
 Neoplasms Antibodies  >2 publications with Hsp90 alpha and Neoplasms
 Dementia Antibodies  >2 publications with Hsp90 alpha and Dementia
 Male Urogenital Diseases Antibodies  >1 publications with Hsp90 alpha and Male Urogenital Diseases
 Cardiovascular Diseases Antibodies  >1 publications with Hsp90 alpha and Cardiovascular Diseases
 Stomach Neoplasms Antibodies  >1 publications with Hsp90 alpha and Stomach Neoplasms
 Liver Diseases Antibodies  >1 publications with Hsp90 alpha and Liver Diseases
 Multiple Myeloma Antibodies  >1 publications with Hsp90 alpha and Multiple Myeloma
 Infertility, Male Antibodies  >1 publications with Hsp90 alpha and Infertility, Male
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with Hsp90 alpha and Blood
 Brain Antibodies  >2 publications with Hsp90 alpha and Brain
 Spleen Antibodies  >1 publications with Hsp90 alpha and Spleen
 Nerve Antibodies  >1 publications with Hsp90 alpha and Nerve
 Stomach Antibodies  >1 publications with Hsp90 alpha and Stomach
 Thymus Antibodies  >1 publications with Hsp90 alpha and Thymus
 Embryonic Tissue Antibodies  >1 publications with Hsp90 alpha and Embryonic Tissue
 Liver Antibodies  >1 publications with Hsp90 alpha and Liver
 Lung Antibodies  >1 publications with Hsp90 alpha and Lung
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