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anti-Hsp90 antibody :: Mouse anti-Human, Hsp90 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200047
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hsp90, Monoclonal Antibody

★Popular Item★
 Also Known As   

Hsp90 antibody

 Product Synonym Names    Heat shock protein HSP 90-alpha; HSP 86; Renal carcinoma antigen NY-REN-38; HSPC1; HSPCA; Heat shock protein 90-alpha Renal carcinoma antigen NY REN 38; D6S182; FLJ26984; FLJ31884; Heat shock 90kDa protein 1 alpha; heat shock protein 90kDa alpha (cytosolic); class A member 2; HSP84; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90AA1; HSP90ALPHA; HSP90N; HSPCAL3; HSPCB; HSPN; LAP2; Lipopolysaccharide associated protein2; LPS associated protein 2; NY REN 38 antigen; hsp90; Heat shock protein HSP 90-alpha
 Product Gene Name   

anti-Hsp90 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X15183 mRNA
 3D Structure    ModBase 3D Structure for P07900
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 Clonality    Monoclonal
 Isotype    Mouse IgG2bheavy chain and k light chain
 Clone Number    4F10
 Host    Mouse
 Species Reactivity    Human,
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human Hsp90 (1-732aa) purified from E. coli
 Clone Note    Anti-human Hsp90 mAb, clone 4F10, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Hsp90 protein.
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 Preparation and Storage    Can be stored at 4C for short term ( 1-2 weeks). For long term storage, aliquot and store at -20C or -70C . Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-Hsp90 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Hsp90 antibody

   Hsp90 is a human heat shock protein. In response to adverse change in their environment, cell from all organisms increase the expression of a class of proteins referred to as heat shock or stress protein. The Hsp90, a highly conserved stress-induced protein, is abundantly expressed in most tissues under non-stress conditions and is required for eukaryotic cell viability. Hsp90 is primarily a cytoplasmic protein and its function remains unknown. It exists in a dimeric form and has been observed to bind to several other cellular proteins such as retro-virus kinases, steroid receptor, heme-regulated protein kinase, actin and tubulin.
 Product Categories/Family for anti-Hsp90 antibody    Heat Shock Proteins
 Applications Tested/Suitable for anti-Hsp90 antibody   

ELISA (EIA), WB (Cell lysate), Immunohistochemistry (IHC)

 Application Notes for anti-Hsp90 antibody    The antibody has been tested by ELISA, Western Blot, and Immunohistochemistry analysis to assure specifity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended diltuion range for Western Blot is 1:500~ 1:200 and immunohistochemistry analysis is 1:100~200. Recommended starting dilution for Western Blot is 1:1000 and Immunohistochemistry is 1:100.
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 Western Blot (WB) of anti-Hsp90 antibody    The Recombinant Human HSP90 (50ng) and Cell lysates(40ug)
were resolved by SDS-PAGE, transferred to PVDF membrane
and probed with anti-human HSP90antibody (1:1000). Proteins
were visualized using a goat anti-mouse secondary antibody
conjugated to HRP and an ECL detection system
Lane 1. : Hsp90 recombinant protein
Lane 2. : 293T cell lysate
Lane 3. : HeLa cell lysate
Lane 4. : HepG2 cell lysate
anti-Hsp90 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC) of anti-Hsp90 antibody    Flow cytometry analysis of HSP90in HepG2cell line,staining at 2-5ug for 1x106cellsredline). The secondary antibody used goat anti-mouse IgGAlexa fluor 488 conjugate. Isotype control antibody was mouse IgG(black line).
anti-Hsp90 antibody Flow Cytometry (FC) (FC/FACS) image
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 Immunohistochemistry (IHC) of anti-Hsp90 antibody    Paraffin embedded sections of human urothelium were incubated with anti-human Hsp90 (1:100)for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detectedusing Diaminobenzidine (DAB)
anti-Hsp90 antibody Immunohistochemistry (IHC) (IHC) image
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 Testing Data(TD) of anti-Hsp90 antibody    ICC/IF analysis of HSP90in HeLa cells line, stained with DAPI(Blue) for nucleus staining and monoclonal anti-human HSP90 antibody (1: 100) with goat anti-mouse IgG-Alexa fluor 488 conjugate(Green).
anti-Hsp90 antibody Testing Data(TD) image
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NCBI/Uniprot data below describe general gene information for Hsp90. It may not necessarily be applicable to this product.
 NCBI GI #    154146191
 NCBI GeneID    3320
 NCBI Accession #    NP_005339 [Other Products]
 NCBI GenBank Nucleotide #    NM_005348.3 [Other Products]
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 UniProt Primary Accession #    P07900 [Other Products]
 UniProt Secondary Accession #    Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5; A8K500; B3KPJ9 [Other Products]
 UniProt Related Accession #    P07900 [Other Products]
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 NCBI Official Full Name    heat shock protein HSP 90-alpha isoform 2
 NCBI Official Synonym Full Names    heat shock protein 90 alpha family class A member 1
 NCBI Official Symbol    HSP90AA1 [Similar Products]
 NCBI Official Synonym Symbols   
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-alpha
 UniProt Protein Name    Heat shock protein HSP 90-alpha
 UniProt Synonym Protein Names   
Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38
 Protein Family    Heat shock protein
 UniProt Gene Name    HSP90AA1 [Similar Products]
 UniProt Synonym Gene Names    HSP90A; HSPC1; HSPCA; HSP 86; HSP86; LAP-2; LPS-associated protein 2 [Similar Products]
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 NCBI Summary for Hsp90    The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for Hsp90    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).
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Product References and Citations for anti-Hsp90 antibody

   B-T, et al., (1984) Molecular & Cellular Biol 4: 2802-2810; Pritchard, K. A, et al., (2001) J Biol Chem 276:17621-17624; Miyamoto, A, et al., (2002) Nature 416:865-869
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 Research Articles on Hsp90    1. Results identified GRP78 and HSP90a as binding partners of PRDM14 in triple-negative breast cancer cells, and all participate in cancer regulation. The interactions were direct and required the C-terminal region including the zinc finger motifs of PRDM14.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Hsp90 antibodyPathways associated with anti-Hsp90 antibody
 Reference Product  PubMed Publications
 PTGES3 antibody  >4 publications with Hsp90 and PTGES3
 STIP1 antibody  >3 publications with Hsp90 and STIP1
 HSPA4 antibody  >2 publications with Hsp90 and HSPA4
 CDC37 antibody  >2 publications with Hsp90 and CDC37
 Products by Pathway  Pathway Diagram
 AURKA Activation By TPX2 Pathway antibodies  AURKA Activation By TPX2 Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Aryl Hydrocarbon Receptor Pathway antibodies  Aryl Hydrocarbon Receptor Pathway Diagram
 Aryl Hydrocarbon Receptor Pathway antibodies  Aryl Hydrocarbon Receptor Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-Hsp90 antibodyOrgans/Tissues associated with anti-Hsp90 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >12 publications with Hsp90 and Nervous System Diseases
 Liver Diseases Antibodies  >8 publications with Hsp90 and Liver Diseases
 Inflammation Antibodies  >8 publications with Hsp90 and Inflammation
 Cardiovascular Diseases Antibodies  >8 publications with Hsp90 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >6 publications with Hsp90 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >5 publications with Hsp90 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >5 publications with Hsp90 and Necrosis
 Liver Neoplasms Antibodies  >5 publications with Hsp90 and Liver Neoplasms
 Lung Neoplasms Antibodies  >4 publications with Hsp90 and Lung Neoplasms
 Breast Neoplasms Antibodies  >4 publications with Hsp90 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with Hsp90 and Blood
 Brain Antibodies  >11 publications with Hsp90 and Brain
 Liver Antibodies  >10 publications with Hsp90 and Liver
 Lung Antibodies  >10 publications with Hsp90 and Lung
 Muscle Antibodies  >10 publications with Hsp90 and Muscle
 Testis Antibodies  >7 publications with Hsp90 and Testis
 Vascular Antibodies  >5 publications with Hsp90 and Vascular
 Heart Antibodies  >5 publications with Hsp90 and Heart
 Embryonic Tissue Antibodies  >4 publications with Hsp90 and Embryonic Tissue
 Bone Antibodies  >4 publications with Hsp90 and Bone
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