Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow Hsp90 rightarrow Monoclonal Hsp90  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • homeobox B7 (HOXB7) ELISA Kit
 • Treponema pallidum TmpA Recombinant Protein
 • CD8a Antibody
 • CD38 Antibody
 • 25-Hydroxyvitamin D3 (HVD3) ELISA Kit
 • Cross-linked C-terminal Telopeptides of type II collagen (CT... ELISA Kit
 • MSH2 Antibody
 • RNA-directed RNA polymerase L (L), partial Recombinant Protein
 • EGR3 Antibody
 • Zn-Metallothionein (ZN-MT) ELISA Kit
 • Dopamine beta-Hydroxylase, N-Terminus, Human (DBH) Antibody
 • Bone Morphogenetic Protein 6 (BMP6) ELISA Kit
 • Catalase (CAT) ELISA Kit
 • Regulated On Activation In Normal T-Cell Expressed And Secre... Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-Hsp90 antibody :: Hsp90 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS475175
Western Blot (WB)
Unit / Price
0.1 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hsp90, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Hsp90 Mouse mAb

 Product Synonym Names    D6S182; FLJ26984; FLJ31884; Heat shock 86 kDa; heat shock 90kDa protein 1 alpha; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein HSP 90 alpha; Heat shock protein HSP 90 beta; Heat shock protein HSP 90-alpha; HS90A_HUMAN; HSP 84; HSP 86; Hsp 90; HSP84; HSP86; Hsp89; Hsp90; HSP90 Beta; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; LAP2; Lipopolysaccharide associated protein2; LPS associated protein 2; NY REN 38 antigen; Renal carcinoma antigen NY-REN-38
 Product Gene Name   

anti-Hsp90 antibody

[Similar Products]
 Product Synonym Gene Name    EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4. [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    X15183 mRNA
 3D Structure    ModBase 3D Structure for P07900
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4B6-G2-H6
 Host    Mouse
Source: Human
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Affinity Purified
 Form/Format    Purified mouse monoclonal in PBS (pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
 Concentration    2.25mg/ml (lot specific)
Section Bar
 Immunogen    Purified recombinant human HSP90AA1 protein fragments expressed in E Coli
 Sensitivity    This antibody detects endogenous levels of Hsp90 alpha and Hsp90 beta.
 Sequence Similarities    Belongs to the heat shock protein 90 family.
 Subunit Structure    Homodimer.Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C STIP1.Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34.Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex.Interacts with CHORDC1 and DNAJC7.Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems.Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity
 Subcellular Location    Cytoplasm. Melanosome. Note:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Section Bar
 Other Notes    Small volumes of anti-Hsp90 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-Hsp90 antibody

   Entrez Summary: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer.The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones.Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
 Product Categories/Family for anti-Hsp90 antibody    Signal Transduction; Protein Trafficking; Chaperones; Heat Shock Proteins; Cancer T; umor biomarkers; Other.
 Applications Tested/Suitable for anti-Hsp90 antibody   

Western Blot (WB)

 Application Notes for anti-Hsp90 antibody    WB: 1:2000
Section Bar
 Western Blot (WB) of anti-Hsp90 antibody    Western blot detection of Hsp90 in Hela, 3T3, C6, K562 and A549 cell lysates using Hsp90 mouse mAb (1:2000 diluted).Exposion time: 4min.Predicted band size:90KDa.Observed band size:90KDa.
anti-Hsp90 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for Hsp90. It may not necessarily be applicable to this product.
 NCBI GI #    153792590
 NCBI GeneID    3320
 NCBI Accession #    NP_001017963.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001017963 [Other Products]
Section Bar
 UniProt Primary Accession #    P07900 [Other Products]
 UniProt Secondary Accession #    Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5; A8K500; B3KPJ9 [Other Products]
 UniProt Related Accession #    P07900 [Other Products]
 Molecular Weight    90
Table BarTOPTable Bar
 NCBI Official Full Name    heat shock protein HSP 90-alpha isoform 1
 NCBI Official Synonym Full Names    heat shock protein 90 alpha family class A member 1
 NCBI Official Symbol    HSP90AA1 [Similar Products]
 NCBI Official Synonym Symbols   
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-alpha
 UniProt Protein Name    Heat shock protein HSP 90-alpha
 UniProt Synonym Protein Names   
Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38
 Protein Family    Heat shock protein
 UniProt Gene Name    HSP90AA1 [Similar Products]
 UniProt Synonym Gene Names    HSP90A; HSPC1; HSPCA; HSP 86; HSP86; LAP-2; LPS-associated protein 2 [Similar Products]
Section Bar
 NCBI Summary for Hsp90    The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Section Bar
 UniProt Comments for Hsp90    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
Table BarTOPTable Bar
 Research Articles on Hsp90    1. this study identified HSP90AA1 as a new potential biomarker for Behcet's disease by comparing highly ranked genes from all the built network-derived gene lists, which was confirmed the with real-world clinical samples
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-Hsp90 antibodyPathways associated with anti-Hsp90 antibody
 Reference Product  PubMed Publications
 HSPA8 antibody  >4 publications with Hsp90 and HSPA8
 AHR antibody  >3 publications with Hsp90 and AHR
 HIF1A antibody  >2 publications with Hsp90 and HIF1A
 AKT1 antibody  >2 publications with Hsp90 and AKT1
 UCHL1 antibody  >2 publications with Hsp90 and UCHL1
 STIP1 antibody  >2 publications with Hsp90 and STIP1
 NR3C1 antibody  >1 publications with Hsp90 and NR3C1
 NOS3 antibody  >1 publications with Hsp90 and NOS3
 MYC antibody  >1 publications with Hsp90 and MYC
 IKBKB antibody  >1 publications with Hsp90 and IKBKB
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with anti-Hsp90 antibodyOrgans/Tissues associated with anti-Hsp90 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with Hsp90 and Neoplasms
 Nervous System Diseases Antibodies  >5 publications with Hsp90 and Nervous System Diseases
 Breast Neoplasms Antibodies  >3 publications with Hsp90 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with Hsp90 and Carcinoma, Hepatocellular
 Infertility, Male Antibodies  >2 publications with Hsp90 and Infertility, Male
 Brain Diseases Antibodies  >2 publications with Hsp90 and Brain Diseases
 Liver Neoplasms Antibodies  >1 publications with Hsp90 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with Hsp90 and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with Hsp90 and Kidney Diseases
 Necrosis Antibodies  >1 publications with Hsp90 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with Hsp90 and Blood
 Brain Antibodies  >5 publications with Hsp90 and Brain
 Liver Antibodies  >3 publications with Hsp90 and Liver
 Testis Antibodies  >3 publications with Hsp90 and Testis
 Stomach Antibodies  >2 publications with Hsp90 and Stomach
 Embryonic Tissue Antibodies  >2 publications with Hsp90 and Embryonic Tissue
 Lung Antibodies  >2 publications with Hsp90 and Lung
 Nerve Antibodies  >2 publications with Hsp90 and Nerve
 Muscle Antibodies  >2 publications with Hsp90 and Muscle
 Bone Antibodies  >2 publications with Hsp90 and Bone
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions