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anti-ICAM1 antibody :: Mouse anti-Human ICAM1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850134
Testing Data
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ICAM1, Monoclonal Antibody

 Also Known As   

ICAM1 Antibody

 Product Synonym Names    BB2; CD54; P3.58; ICAM1
 Product Gene Name   

anti-ICAM1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 611162
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 Clonality    Monoclonal
 Clone Number    6G12
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of human ICAM1(28-480aa) expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C.
 Other Notes    Small volumes of anti-ICAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ICAM1 antibody

   Background: ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils), with lower levels that increase in inflammation. ICAM1 is also detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.
 Product Categories/Family for anti-ICAM1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-ICAM1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ICAM1 antibody    WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000
Not yet tested in other applications.
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 Testing Data of anti-ICAM1 antibody    Figure 1: Western blot analysis using ICAM1 mouse mAb against ICAM1-hIgGFc transfected HEK293 (1) cell lysate.
anti-ICAM1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ICAM1. It may not necessarily be applicable to this product.
 NCBI GI #    167466198
 NCBI GeneID    3383
 NCBI Accession #    NP_000192.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000201.2 [Other Products]
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 UniProt Secondary Accession #    Q5NKV7; Q96B50; B2R6M3 [Other Products]
 UniProt Related Accession #    P05362 [Other Products]
 Molecular Weight    57.8kDa
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 NCBI Official Full Name    intercellular adhesion molecule 1
 NCBI Official Synonym Full Names    intercellular adhesion molecule 1
 NCBI Official Symbol    ICAM1 [Similar Products]
 NCBI Official Synonym Symbols   
BB2; CD54; P3.58
[Similar Products]
 NCBI Protein Information    intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
 UniProt Protein Name    Intercellular adhesion molecule 1
 UniProt Synonym Protein Names   
Major group rhinovirus receptor; CD_antigen: CD54
 Protein Family    Intercellular adhesion molecule
 UniProt Gene Name    ICAM1 [Similar Products]
 UniProt Synonym Gene Names    ICAM-1 [Similar Products]
 UniProt Entry Name    ICAM1_HUMAN
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 NCBI Summary for ICAM1    This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ICAM1    ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.

Protein type: Cell adhesion; Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: extracellular space; focal adhesion; cell surface; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane

Molecular Function: integrin binding; viral receptor activity; protein binding; transmembrane receptor activity; receptor activity

Biological Process: entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; cellular response to nutrient levels; leukocyte adhesion; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; regulation of cell adhesion; response to drug; virion attachment, binding of host cell surface receptor; regulation of immune response; negative regulation of calcium ion transport; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to copper ion; positive regulation of actin filament polymerization; positive regulation of vasoconstriction; cell adhesion mediated by integrin; adhesion to host; response to ionizing radiation; leukocyte migration

Disease: Malaria, Susceptibility To
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 Research Articles on ICAM1    1. NF-kappaB/ICAM-1 pathway induced adhesion of neutrophils and was involved in renal injury after hypoxia-ischemia injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ICAM1 antibodyPathways associated with anti-ICAM1 antibody
 Reference Product  PubMed Publications
 ITGB2 antibody  >879 publications with ICAM1 and ITGB2
 ITGAL antibody  >472 publications with ICAM1 and ITGAL
 ITGAM antibody  >437 publications with ICAM1 and ITGAM
 CD44 antibody  >370 publications with ICAM1 and CD44
 IL6 antibody  >148 publications with ICAM1 and IL6
 ITGAX antibody  >139 publications with ICAM1 and ITGAX
 SELE antibody  >78 publications with ICAM1 and SELE
 HLA-B antibody  >29 publications with ICAM1 and HLA-B
 DIF antibody  >3 publications with ICAM1 and DIF
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
Diseases associated with anti-ICAM1 antibodyOrgans/Tissues associated with anti-ICAM1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5540 publications with ICAM1 and Inflammation
 Necrosis Antibodies  >4736 publications with ICAM1 and Necrosis
 Cardiovascular Diseases Antibodies  >3592 publications with ICAM1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1436 publications with ICAM1 and Atherosclerosis
 Reperfusion Injury Antibodies  >874 publications with ICAM1 and Reperfusion Injury
 Myocardial Ischemia Antibodies  >787 publications with ICAM1 and Myocardial Ischemia
 Kidney Diseases Antibodies  >752 publications with ICAM1 and Kidney Diseases
 Liver Diseases Antibodies  >547 publications with ICAM1 and Liver Diseases
 Hypertension Antibodies  >518 publications with ICAM1 and Hypertension
 Asthma Antibodies  >501 publications with ICAM1 and Asthma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11674 publications with ICAM1 and Blood
 Vascular Antibodies  >8724 publications with ICAM1 and Vascular
 Lung Antibodies  >1751 publications with ICAM1 and Lung
 Heart Antibodies  >1270 publications with ICAM1 and Heart
 Skin Antibodies  >1191 publications with ICAM1 and Skin
 Liver Antibodies  >1174 publications with ICAM1 and Liver
 Kidney Antibodies  >1164 publications with ICAM1 and Kidney
 Brain Antibodies  >1159 publications with ICAM1 and Brain
 Muscle Antibodies  >1032 publications with ICAM1 and Muscle
 Embryonic Tissue Antibodies  >770 publications with ICAM1 and Embryonic Tissue
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