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anti-ICOS antibody :: Rat anti-Mouse ICOS Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS378147 anti-ICOS antibody
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ICOS, Monoclonal Antibody

★Popular Item★
 Also Known As   

ICOS

 Product Synonym Names    AILIM; CCLP; CRP-1; H4; Ly115
 Product Gene Name   

anti-ICOS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AJ277832 mRNA
 3D Structure    ModBase 3D Structure for Q9Y6W8
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 Clonality    Monoclonal
 Isotype    IgG2b Kappa
 Clone Number    7E.17G9
 Host    Rat
 Species Reactivity    Mouse
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 Purity/Purification    >95%
 Form/Format    PBS, pH7
 Concentration    2mg/ml (lot specific)
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 Preservative    None
 Total Protein    500ug
 Endotoxin    <2EU/mg
 Sterile    0.2um filtration
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 Preparation and Storage    Store at -20 degree C. For long term storage, aliquot and store frozen. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-ICOS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ICOS antibody   

Activation, Flow Cytometry (FC/FACS)

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NCBI/Uniprot data below describe general gene information for ICOS. It may not necessarily be applicable to this product.
 NCBI GI #    15029518
 NCBI GeneID    29851
 NCBI Accession #    NP_036224.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012092.3 [Other Products]
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 UniProt Primary Accession #    Q9Y6W8 [Other Products]
 UniProt Secondary Accession #    Q8N6W8 [Other Products]
 UniProt Related Accession #    Q9Y6W8 [Other Products]
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 NCBI Official Full Name    inducible T-cell costimulator
 NCBI Official Synonym Full Names    inducible T-cell costimulator
 NCBI Official Symbol    ICOS [Similar Products]
 NCBI Official Synonym Symbols   
AILIM; CD278; CVID1
[Similar Products]
 NCBI Protein Information    inducible T-cell costimulator
 UniProt Protein Name    Inducible T-cell costimulator
 UniProt Synonym Protein Names   
Activation-inducible lymphocyte immunomediatory molecule; CD_antigen: CD278
 Protein Family    ICOS ligand
 UniProt Gene Name    ICOS [Similar Products]
 UniProt Synonym Gene Names    AILIM [Similar Products]
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 NCBI Summary for ICOS    The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ICOS    ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33.2

Cellular Component: plasma membrane

Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Biological Process: phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; T cell costimulation

Disease: Immunodeficiency, Common Variable, 1; Immunodeficiency, Common Variable, 2
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 Research Articles on ICOS    1. This is the first replication association study of rs4325730 upstream of ICOS with AIH in the Japanese population and rs4325730G is a risk allele.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ICOS antibodyPathways associated with anti-ICOS antibody
 Reference Product  PubMed Publications
 CTLA4 antibody  >202 publications with ICOS and CTLA4
 ICOSLG antibody  >60 publications with ICOS and ICOSLG
 RC3H1 antibody  >17 publications with ICOS and RC3H1
 PIK3CD antibody  >5 publications with ICOS and PIK3CD
 CD40LG antibody  >5 publications with ICOS and CD40LG
 PIK3CB antibody  >2 publications with ICOS and PIK3CB
 PIK3CG antibody  >1 publications with ICOS and PIK3CG
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-ICOS antibodyOrgans/Tissues associated with anti-ICOS antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >150 publications with ICOS and Inflammation
 Death Antibodies  >109 publications with ICOS and Death
 Disease Models, Animal Antibodies  >108 publications with ICOS and Disease Models, Animal
 Necrosis Antibodies  >87 publications with ICOS and Necrosis
 Respiratory Tract Diseases Antibodies  >78 publications with ICOS and Respiratory Tract Diseases
 Hypersensitivity Antibodies  >68 publications with ICOS and Hypersensitivity
 Lung Diseases Antibodies  >59 publications with ICOS and Lung Diseases
 Common Variable Immunodeficiency Antibodies  >45 publications with ICOS and Common Variable Immunodeficiency
 Respiratory Hypersensitivity Antibodies  >44 publications with ICOS and Respiratory Hypersensitivity
 Liver Diseases Antibodies  >20 publications with ICOS and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >817 publications with ICOS and Blood
 Lung Antibodies  >62 publications with ICOS and Lung
 Heart Antibodies  >41 publications with ICOS and Heart
 Brain Antibodies  >29 publications with ICOS and Brain
 Thymus Antibodies  >21 publications with ICOS and Thymus
 Pharynx Antibodies  >9 publications with ICOS and Pharynx
 Thyroid Antibodies  >8 publications with ICOS and Thyroid
 Uterus Antibodies  >2 publications with ICOS and Uterus
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