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anti-ID2 antibody :: Mouse anti-Human ID2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120287
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ID2, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human ID2

 Product Synonym Names    Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2); GIG8; ID2A; ID2H; MGC26389
 Product Gene Name   

anti-ID2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600386
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2457C5a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-ID2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ID2 antibody

   The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-ID2 antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

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 Quality Control of anti-ID2 antibody    Western blot analysis of immunized recombinant protein, using anti-ID2 monoclonal antibody.
anti-ID2 antibody Quality Control image
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 Quality Control #2 of anti-ID2 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-ID2 antibody Quality Control #2 image
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 Immunocytochemistry (ICC) of anti-ID2 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-ID2 mAb. [Lot No. 2457C5a-1]
anti-ID2 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for ID2. It may not necessarily be applicable to this product.
 NCBI GI #    33946335
 NCBI GeneID    3398
 NCBI Accession #    NP_002157.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002166 [Other Products]
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 UniProt Related Accession #    Q02363 [Other Products]
 Molecular Weight    14,917 Da
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 NCBI Official Full Name    Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA
 NCBI Official Synonym Full Names    inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
 NCBI Official Symbol    ID2 [Similar Products]
 NCBI Official Synonym Symbols   
GIG8; ID2A; ID2H; bHLHb26
[Similar Products]
 NCBI Protein Information    DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; cell growth-inhibiting gene 8; class B basic helix-loop-helix protein 26; helix-loop-helix protein ID2; inhibitor of differentiation 2
 UniProt Protein Name    DNA-binding protein inhibitor ID-2
 UniProt Synonym Protein Names   
Class B basic helix-loop-helix protein 26; bHLHb26; Inhibitor of DNA binding 2; Inhibitor of differentiation 2
 Protein Family    DNA-binding protein inhibitor
 UniProt Gene Name    ID2 [Similar Products]
 UniProt Entry Name    ID2_HUMAN
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 NCBI Summary for ID2    The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
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 UniProt Comments for ID2    ID2: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: nucleoplasm; microtubule cytoskeleton; centrosome; protein complex; cytoplasm; nucleus; chromatin; cytosol

Molecular Function: protein dimerization activity; protein binding

Biological Process: regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of smooth muscle cell proliferation; cell maturation; negative regulation of transcription from RNA polymerase II promoter; entrainment of circadian clock by photoperiod; locomotor rhythm; natural killer cell differentiation; embryonic digestive tract morphogenesis; negative regulation of osteoblast differentiation; circadian regulation of gene expression; positive regulation of macrophage differentiation; oligodendrocyte development; positive regulation of astrocyte differentiation; negative regulation of B cell differentiation; Peyer's patch development; transcription, DNA-dependent; positive regulation of erythrocyte differentiation; olfactory bulb development; negative regulation of transcription factor activity; neuron fate commitment; mammary gland epithelial cell proliferation; enucleate erythrocyte differentiation; regulation of circadian rhythm; negative regulation of DNA binding; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; positive regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; metanephros development; positive regulation of blood pressure
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 Research Articles on ID2    1. role of Id2-TGFbeta crosstalk in reversible adaptive plasticity in neuroblastoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ID2 antibodyPathways associated with anti-ID2 antibody
 Reference Product  PubMed Publications
 MYC antibody  >58 publications with ID2 and MYC
 TCF3 antibody  >35 publications with ID2 and TCF3
 BMP4 antibody  >31 publications with ID2 and BMP4
 CTNNB1 antibody  >19 publications with ID2 and CTNNB1
 TCF4 antibody  >12 publications with ID2 and TCF4
 CDK2 antibody  >8 publications with ID2 and CDK2
 RB1 antibody  >3 publications with ID2 and RB1
 PKD2 antibody  >2 publications with ID2 and PKD2
 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with anti-ID2 antibodyOrgans/Tissues associated with anti-ID2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >47 publications with ID2 and Carcinoma
 Nervous System Diseases Antibodies  >43 publications with ID2 and Nervous System Diseases
 Skin Diseases Antibodies  >29 publications with ID2 and Skin Diseases
 Cell Transformation, Neoplastic Antibodies  >27 publications with ID2 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >26 publications with ID2 and Adenocarcinoma
 Inflammation Antibodies  >20 publications with ID2 and Inflammation
 Breast Neoplasms Antibodies  >20 publications with ID2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >19 publications with ID2 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >18 publications with ID2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >16 publications with ID2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >190 publications with ID2 and Blood
 Bone Antibodies  >146 publications with ID2 and Bone
 Brain Antibodies  >80 publications with ID2 and Brain
 Embryonic Tissue Antibodies  >64 publications with ID2 and Embryonic Tissue
 Nerve Antibodies  >62 publications with ID2 and Nerve
 Liver Antibodies  >56 publications with ID2 and Liver
 Bone Marrow Antibodies  >54 publications with ID2 and Bone Marrow
 Vascular Antibodies  >44 publications with ID2 and Vascular
 Heart Antibodies  >33 publications with ID2 and Heart
 Kidney Antibodies  >30 publications with ID2 and Kidney
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