NP_006426.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interferon-induced transmembrane protein 2
NCBI Official Synonym Full Names
interferon induced transmembrane protein 2
NCBI Official Synonym Symbols
NCBI Protein Information
interferon-induced transmembrane protein 2; dispanin subfamily A member 2c; interferon-inducible protein 1-8D
UniProt Protein Name
Interferon-induced transmembrane protein 2
UniProt Synonym Protein Names
Dispanin subfamily A member 2c; DSPA2c; Interferon-inducible protein 1-8D
UniProt Synonym Gene Names
UniProt Entry Name
IFM2_HUMAN
UniProt Comments for IFITM2
IFITM2: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Belongs to the CD225/Dispanin family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: plasma membrane; integral to membrane
Biological Process: negative regulation of viral genome replication; negative regulation of virion penetration into host cell; response to virus; cytokine and chemokine mediated signaling pathway; immune response; defense response to virus
Research Articles on IFITM2
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Products associated with anti-IFITM2 antibody
Pathways associated with anti-IFITM2 antibody
Diseases associated with anti-IFITM2 antibody
Organs/Tissues associated with anti-IFITM2 antibody
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