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anti-Ifng antibody :: Rat IFN GAMMA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS210342
Testing Data
Unit / Price
0.2 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFN GAMMA (Ifng), Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE INTERFERON GAMMA:Biotin

 Product Gene Name   

anti-Ifng antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P01580
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    XMG1.2
 Host    Rat
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 Form/Format    Biotin
Purified IgG conjugated to Biotin - liquid
 Concentration    IgG concentration 1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or -20 degree C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-Ifng antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Ifng antibody

   Rat anti Mouse Interferon gamma antibody, clone XMG1.2 recognizes murine IFN gamma. Rat anti Mouse Interferon gamma antibody, clone XMG1.2 may be used for the detection of intracellular IFN gamma using flow cytometric techniques and has been shown to block the functional activity of murine interferon gamma.
 Applications Tested/Suitable for anti-Ifng antibody   

ELISA (EIA), Flow cytometry (FC/FACS)*

 Application Notes for anti-Ifng antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
ELISA: Minimum Dilution: 0.25ug/ml; Maximum Dilution: 2.0ug/ml
Flow Cytometry: Application Note: Membrane permeabilisation is required for this application. MyBioSource recommends the use of Leucoperm for this purpose.
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 Testing Data of anti-Ifng antibody    Detection of Recombinant Mouse Interferon Gamma in Sandwich ELISA using Rat anti Mouse Interferon Gamma: Endotoxin Low (MBS216933) as a coating antibody and a biotinylated Rabbit anti Mouse Interferon Gamma as the detection reagent
anti-Ifng antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Ifng. It may not necessarily be applicable to this product.
 NCBI GI #    33468859
 NCBI GeneID    15978
 NCBI Accession #    NP_032363.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008337.3 [Other Products]
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 UniProt Primary Accession #    P01580 [Other Products]
 UniProt Secondary Accession #    Q542B8 [Other Products]
 UniProt Related Accession #    P01580 [Other Products]
 Molecular Weight    17,907 Da [Similar Products]
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 NCBI Official Full Name    interferon gamma
 NCBI Official Synonym Full Names    interferon gamma
 NCBI Official Symbol    Ifng [Similar Products]
 NCBI Official Synonym Symbols   
Ifg; IFN-g
[Similar Products]
 NCBI Protein Information    interferon gamma; IFN-gamma; gamma interferon
 UniProt Protein Name    Interferon gamma
 Protein Family    Interferon
 UniProt Gene Name    Ifng [Similar Products]
 UniProt Synonym Gene Names    IFN-gamma [Similar Products]
 UniProt Entry Name    IFNG_MOUSE
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 NCBI Summary for Ifng    This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]
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 UniProt Comments for Ifng    IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family.

Protein type: Membrane protein, integral; Secreted, signal peptide; Cytokine; Secreted

Cellular Component: extracellular space; cell; extracellular region; intracellular; external side of plasma membrane

Molecular Function: protein binding; interferon-gamma receptor binding; cytokine activity

Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of cell adhesion; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; apoptosis; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; positive regulation of interleukin-12 production; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-6 biosynthetic process; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of killing of cells of another organism; sensory perception of mechanical stimulus; positive regulation of interleukin-1 beta secretion; positive regulation of membrane protein ectodomain proteolysis; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of MHC class II biosynthetic process; regulation of growth; positive regulation of cell proliferation; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; regulation of the force of heart contraction; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of synaptic transmission, cholinergic; neutrophil chemotaxis; regulation of immune response; adaptive immune response; CD8-positive, alpha-beta T cell differentiation during immune response; negative regulation of myelination; unfolded protein response; response to virus; defense response to protozoan; positive regulation of tumor necrosis factor production; humoral immune response; inflammatory cell apoptosis; antigen processing and presentation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of interleukin-12 biosynthetic process; positive regulation of chemokine biosynthetic process; negative regulation of interleukin-17 production; protein import into nucleus, translocation; defense response to bacterium; neutrophil apoptosis; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; regulation of insulin secretion
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 Research Articles on Ifng    1. Induction of IFNG production by U0126 inhibits tumor growth in a mouse model.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Ifng antibodyPathways associated with anti-Ifng antibody
 Reference Product  PubMed Publications
 Il4 antibody  >102 publications with Ifng and Il4
 Il6 antibody  >88 publications with Ifng and Il6
 Il2 antibody  >59 publications with Ifng and Il2
 Stat1 antibody  >41 publications with Ifng and Stat1
 Ifngr1 antibody  >31 publications with Ifng and Ifngr1
 Il18 antibody  >24 publications with Ifng and Il18
 Irf1 antibody  >16 publications with Ifng and Irf1
 Socs1 antibody  >10 publications with Ifng and Socs1
 Jak2 antibody  >6 publications with Ifng and Jak2
 Jak1 antibody  >6 publications with Ifng and Jak1
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Diseases associated with anti-Ifng antibodyOrgans/Tissues associated with anti-Ifng antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >155 publications with Ifng and Necrosis
 Autoimmune Diseases Antibodies  >90 publications with Ifng and Autoimmune Diseases
 Respiratory Tract Diseases Antibodies  >71 publications with Ifng and Respiratory Tract Diseases
 Hepatitis Antibodies  >34 publications with Ifng and Hepatitis
 Lymphoproliferative Disorders Antibodies  >21 publications with Ifng and Lymphoproliferative Disorders
 Diabetes Mellitus, Type 1 Antibodies  >17 publications with Ifng and Diabetes Mellitus, Type 1
 HIV Infections Antibodies  >17 publications with Ifng and HIV Infections
 Hepatitis C Antibodies  >16 publications with Ifng and Hepatitis C
 Arthritis, Rheumatoid Antibodies  >15 publications with Ifng and Arthritis, Rheumatoid
 Leishmaniasis Antibodies  >11 publications with Ifng and Leishmaniasis
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >40 publications with Ifng and Spleen
 Mixed Antibodies  >12 publications with Ifng and Mixed
 Embryonic Tissue Antibodies  >9 publications with Ifng and Embryonic Tissue
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