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anti-Ifng antibody :: Rat anti-Mouse IFN-g Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS670352 anti-Ifng antibody
Unit / Price
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFN-g (Ifng), Monoclonal Antibody

★Popular Item★
 Also Known As   

Rat Anti-Mouse IFN-g-FITC

 Product Synonym Names    Rat Anti-Mouse IFN-gamma
 Product Gene Name   

anti-Ifng antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000076.6 (118441047..118445892). Location: 10 D2; 10 66.75 cM
 3D Structure    ModBase 3D Structure for P01580
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    XMG1.2
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    Mouse Interferon-gamma (IFN-gamma) This is a neutralizing antibody
 Form/Format    Fluorescein (FITC) Conjugate
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 Immunogen    E. coli-expressed recombinant mouse IFN-gamma
 Characterization    To ensure acceptable performance, each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.
 Warning    Reagents contain sodium azide which is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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 Preparation and Storage    The fluorescein (FITC) conjugate is supplied as 100 tests in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C.
 Other Notes    Small volumes of anti-Ifng antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Ifng antibody   

ELISA

 Application Notes for anti-Ifng antibody    ELISA: XMG1.2 monoclonal antibody can be used as a capture antibody in a sandwich ELISA for quantifying mouse IFN-gamma protein levels. Biotinylated XMG1.2 antibody can be paired with a suitable purified capture antibody, with purified recombinant human IFN-gamma as the standard.; Western Blot: The purified XMG1.2 antibody is also useful for Western Blot applications. For Western Blot, a concentration of 1-5 ug/mL (in conjunction with AP-labeled Goat Anti-Rat-Ig, has been found to enable detection of <= 100 ng/lane of recombinant mouse IFN-gamma under reducing conditions.; Immunofluorescence/Flow Cytometry: XMG1.2 antibody is useful for intracytoplasmic staining and flow cytometric analysis to identify and enumerate IFN-gamma-positive cells within mixed cell populations.4-6 Recombinant mouse IFN-gamma or Rat IgG1 should be used as a specificity control. FITC conjugated XMG1.2 antibodies are useful for intracellular staining in cells producing IFN-gamma. Intracellular staining buffers are recommended for this application.; Neutralization: The LE/AF form of XMG1.2 can be used for neutralizing mouse IFN-gamma bioactivity. A suitable LE/AF Rat IgG1 should be used as an isotype control.; Since applications vary, each investigator should determine the optimal concentration appropriate for individual applications.
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NCBI/Uniprot data below describe general gene information for Ifng. It may not necessarily be applicable to this product.
 NCBI GI #    33468859
 NCBI GeneID    15978
 NCBI Accession #    NP_032363.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008337.3 [Other Products]
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 UniProt Primary Accession #    P01580 [Other Products]
 UniProt Secondary Accession #    Q542B8 [Other Products]
 UniProt Related Accession #    P01580 [Other Products]
 Molecular Weight    17,907 Da [Similar Products]
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 NCBI Official Full Name    interferon gamma
 NCBI Official Synonym Full Names    interferon gamma
 NCBI Official Symbol    Ifng [Similar Products]
 NCBI Official Synonym Symbols   
Ifg; IFN-g
[Similar Products]
 NCBI Protein Information    interferon gamma; IFN-gamma; gamma interferon
 UniProt Protein Name    Interferon gamma
 Protein Family    Interferon
 UniProt Gene Name    Ifng [Similar Products]
 UniProt Synonym Gene Names    IFN-gamma [Similar Products]
 UniProt Entry Name    IFNG_MOUSE
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 NCBI Summary for Ifng    This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]
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 UniProt Comments for Ifng    Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Subunit structure: Homodimer.

Subcellular location: Secreted.

Tissue specificity: Released primarily from activated T lymphocytes.

Sequence similarities: Belongs to the type II (or gamma) interferon family.
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Product References and Citations for anti-Ifng antibody

   1. Cherwinski, H.M., J.H. Schumacher, K.D. Brown, and T.R. Mossman. 1987. J. Exp. Med. 166:1229.
2. Abrams, J.S., M.-G. Roncarolo, H.. Yssel, U. Andersson, G.J. Gleich, and J.E., Silver. 1992. Immunol. Rev. 127:5.
3. Sander, B., I. Hoiden, U. Andersson, E. Moller, and J. Abrams. 1993. J. Immunol. Meth. 166:201.
4. Vickingson, A., K. Pederson, and D. Muller. 1994. J. Immunol. Meth. 173:219.
5. Ferrick, D.A., M.D. Schrenzel, T. Mulvania, B. Hsieh, W.G. Ferlin, and H. Lepper. 1995. Nature 373:255.
6. Hsieh, B., M. Schrenzel, T. Mulvania, H. Lepper, L. DiMolfetto-Landon, and D. Ferrick. 1996. J. Immunol. 156:232.
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 Research Articles on Ifng    1. Styrax japonica glycoprotein strongly increased cytokine IFN-gamma expression in splenocytes induced by diethylnitrosamine (DEN), suggesting that glycoprotein could improve cellular immune function in DEN-induced mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Ifng antibodyPathways associated with anti-Ifng antibody
 Reference Product  PubMed Publications
 Il4 antibody  >69 publications with Ifng and Il4
 Il6 antibody  >63 publications with Ifng and Il6
 Il2 antibody  >38 publications with Ifng and Il2
 Stat1 antibody  >28 publications with Ifng and Stat1
 Ifngr1 antibody  >24 publications with Ifng and Ifngr1
 Il18 antibody  >20 publications with Ifng and Il18
 Cxcl9 antibody  >8 publications with Ifng and Cxcl9
 Socs1 antibody  >8 publications with Ifng and Socs1
 Jak2 antibody  >3 publications with Ifng and Jak2
 Jak1 antibody  >3 publications with Ifng and Jak1
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
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 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
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 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with anti-Ifng antibodyOrgans/Tissues associated with anti-Ifng antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >107 publications with Ifng and Necrosis
 Autoimmune Diseases Antibodies  >71 publications with Ifng and Autoimmune Diseases
 Respiratory Tract Diseases Antibodies  >51 publications with Ifng and Respiratory Tract Diseases
 Hepatitis Antibodies  >24 publications with Ifng and Hepatitis
 MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO Antibodies  >21 publications with Ifng and MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
 Lymphoproliferative Disorders Antibodies  >16 publications with Ifng and Lymphoproliferative Disorders
 Diabetes Mellitus, Type 1 Antibodies  >15 publications with Ifng and Diabetes Mellitus, Type 1
 HIV Infections Antibodies  >13 publications with Ifng and HIV Infections
 Arthritis, Rheumatoid Antibodies  >11 publications with Ifng and Arthritis, Rheumatoid
 Hepatitis C Antibodies  >10 publications with Ifng and Hepatitis C
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >32 publications with Ifng and Spleen
 Mixed Antibodies  >11 publications with Ifng and Mixed
 Embryonic Tissue Antibodies  >7 publications with Ifng and Embryonic Tissue
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