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anti-IFN-gamma antibody :: Mouse IFN-gamma Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS592270 anti-IFN-gamma antibody
Unit / Price
0.5 mg  /  $490 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFN-gamma, Monoclonal Antibody

 Also Known As   

mAb anti-Human IFN-gamma

 Product Synonym Names    Interferon Gamma (IFN-gamma); Interferon Gamma (IFN-g); Mouse monoclonal antibody to human Interferon-gamma (IFN-gamma)
 Product Gene Name   

anti-IFN-gamma antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147570
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 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    23
 Host    Mouse
 Species Reactivity    Human. Other species not tested
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 Specificity    This antibody recognizes both recombinant and native human IFN-gamma.
Interferon Gamma (IFN-gamma)
 Purity/Purification    Protein G affinity purified
 Form/Format    Lyophilized from a solution in 0.01M PBS, pH 7.0
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 Target Protein    Human IFN-gamma
 Immunogen    Purified recombinant human IFN-gamma
 Myeloma    Sp2/0-Ag14
 Light Chain    Kappa
 Reconstitution    Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
 Research Area    Pro-inflammatory cytokine, anti-tumour and anti-viral immunity
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-IFN-gamma antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IFN-gamma antibody

   Mouse monoclonal antibody to human Interferon-gamma (IFN-γ (gamma)), Protein G affinity purified
 Product Categories/Family for anti-IFN-gamma antibody    Primary antibodies; Monoclonal Antibodies to Human Cytokines and Growth Factors
 Applications Tested/Suitable for anti-IFN-gamma antibody   

ELISA (EIA)

 Application Notes for anti-IFN-gamma antibody    ELISA: The antibody reacts with recombinant IFN-gamma coated plate at 0.1ng/mL of antibody concentration
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NCBI/Uniprot data below describe general gene information for IFN-gamma. It may not necessarily be applicable to this product.
 NCBI GI #    56786138
 NCBI GeneID    3458
 NCBI Accession #    NP_000610.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000619.2 [Other Products]
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 UniProt Secondary Accession #    Q53ZV4; B5BU88 [Other Products]
 UniProt Related Accession #    P01579 [Other Products]
 Molecular Weight    19,348 Da
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 NCBI Official Full Name    interferon gamma
 NCBI Official Synonym Full Names    interferon, gamma
 NCBI Official Symbol    IFNG [Similar Products]
 NCBI Official Synonym Symbols   
IFG; IFI
[Similar Products]
 NCBI Protein Information    interferon gamma; IFN-gamma; immune interferon
 UniProt Protein Name    Interferon gamma
 UniProt Synonym Protein Names   
Immune interferon
 UniProt Gene Name    IFNG [Similar Products]
 UniProt Entry Name    IFNG_HUMAN
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 NCBI Summary for IFN-gamma    This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]
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 UniProt Comments for IFN-gamma    IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family.

Protein type: Cytokine; Secreted; Secreted, signal peptide; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: interferon-gamma receptor binding; cytokine activity

Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; apoptosis; positive regulation of interleukin-23 production; negative regulation of smooth muscle cell proliferation; positive regulation of interleukin-12 production; positive regulation of interleukin-6 biosynthetic process; negative regulation of epithelial cell differentiation; positive regulation of killing of cells of another organism; sensory perception of mechanical stimulus; positive regulation of interleukin-1 beta secretion; negative regulation of transcription from RNA polymerase II promoter; positive regulation of membrane protein ectodomain proteolysis; cell surface receptor linked signal transduction; positive regulation of MHC class II biosynthetic process; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; regulation of the force of heart contraction; positive regulation of peptidyl-serine phosphorylation of STAT protein; response to drug; positive regulation of synaptic transmission, cholinergic; neutrophil chemotaxis; adaptive immune response; CD8-positive, alpha-beta T cell differentiation during immune response; negative regulation of myelination; unfolded protein response; cytokine and chemokine mediated signaling pathway; response to virus; defense response to protozoan; positive regulation of tumor necrosis factor production; humoral immune response; antigen processing and presentation; positive regulation of tyrosine phosphorylation of Stat1 protein; negative regulation of interleukin-17 production; positive regulation of interleukin-12 biosynthetic process; positive regulation of chemokine biosynthetic process; protein import into nucleus, translocation; defense response to bacterium; neutrophil apoptosis; positive regulation of transcription from RNA polymerase II promoter; cell motility; positive regulation of neuron differentiation; regulation of insulin secretion

Disease: Hepatitis C Virus, Susceptibility To; Aplastic Anemia; Tuberous Sclerosis 2; Mycobacterium Tuberculosis, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on IFN-gamma    1. Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-gamma by a T-bet-dependent mechanism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IFN-gamma antibodyPathways associated with anti-IFN-gamma antibody
 Reference Product  PubMed Publications
 CD4 antibody  >160 publications with IFN-gamma and CD4
 IL2 antibody  >59 publications with IFN-gamma and IL2
 TBX21 antibody  >55 publications with IFN-gamma and TBX21
 STAT1 antibody  >41 publications with IFN-gamma and STAT1
 IFNGR1 antibody  >31 publications with IFN-gamma and IFNGR1
 IL18 antibody  >24 publications with IFN-gamma and IL18
 IRF1 antibody  >16 publications with IFN-gamma and IRF1
 CD86 antibody  >7 publications with IFN-gamma and CD86
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
Diseases associated with anti-IFN-gamma antibodyOrgans/Tissues associated with anti-IFN-gamma antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >156 publications with IFN-gamma and Necrosis
 Autoimmune Diseases Antibodies  >91 publications with IFN-gamma and Autoimmune Diseases
 Respiratory Tract Diseases Antibodies  >71 publications with IFN-gamma and Respiratory Tract Diseases
 Hepatitis Antibodies  >34 publications with IFN-gamma and Hepatitis
 Lymphoproliferative Disorders Antibodies  >22 publications with IFN-gamma and Lymphoproliferative Disorders
 Diabetes Mellitus, Type 1 Antibodies  >17 publications with IFN-gamma and Diabetes Mellitus, Type 1
 HIV Infections Antibodies  >17 publications with IFN-gamma and HIV Infections
 Hepatitis C Antibodies  >16 publications with IFN-gamma and Hepatitis C
 Arthritis, Rheumatoid Antibodies  >15 publications with IFN-gamma and Arthritis, Rheumatoid
 Colitis Antibodies  >14 publications with IFN-gamma and Colitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >503 publications with IFN-gamma and Blood
 Kidney Antibodies  >43 publications with IFN-gamma and Kidney
 Lymph Node Antibodies  >27 publications with IFN-gamma and Lymph Node
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