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anti-IGF1R antibody :: Mouse IGF-1 receptor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190274 anti-IGF1R antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF-1 receptor (IGF1R), Monoclonal Antibody

 Also Known As   

IGF-1 Receptor Monoclonal Antibody

 Product Synonym Names    Anti-IGF-1 receptor; IGF-1 Receptor
 Product Gene Name   

anti-IGF1R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_010443.3 (143851692..144145063, complement). Location: 1q17-q21; 1
 3D Structure    ModBase 3D Structure for Q29000
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 Clonality    Monoclonal
 Isotype    IgG1
 Host    Mouse
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 Specificity    Anti-IGF-1 receptor [Murine MAb recognizes human IGF-1 receptor; stimulates binding of IGF-1 and 2, stimulates cell growth.]
All three clones are specific for the human IGF-1 receptor
This product (3B7) stimulates binding of IGF-1 and -2; stimulates basal and IGF- 1 stimulated cell growth.
 Form/Format    100 ug Protein G-purified antibody in PBS, pH 7.4
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 Antigen    Purified human placental IGF-1 receptors.
 Stabilizer    None
 Preservatives    None. Available on request.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles
 Other Notes    Small volumes of anti-IGF1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IGF1R antibody    Growth Factors/Cytokines/Receptor Antibodies
 Applications Tested/Suitable for anti-IGF1R antibody   

Immunoblot, Immunoprecipitation

 Application Notes for anti-IGF1R antibody    Use these antibodies in research studies to delineate signal transduction pathways specific for IGF's and for detecting IGF-1 receptors in crude samples. 35101 may be used to immunoprecipitate IGF-1 receptors. 35102 and 35103 can recognize the IGF-1 alpha subunit on immunoblots.
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NCBI/Uniprot data below describe general gene information for IGF1R. It may not necessarily be applicable to this product.
 NCBI GI #    47523430
 NCBI GeneID    397350
 NCBI Accession #    NP_999337.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_214172.1 [Other Products]
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 UniProt Primary Accession #    Q29000 [Other Products]
 UniProt Secondary Accession #    Q28951 [Other Products]
 UniProt Related Accession #    Q29000 [Other Products]
 Molecular Weight    34,615 Da [Similar Products]
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 NCBI Official Full Name    insulin-like growth factor 1 receptor
 NCBI Official Symbol    IGF1R [Similar Products]
 NCBI Official Synonym Symbols   
IGF1R
[Similar Products]
 NCBI Protein Information    insulin-like growth factor 1 receptor; IGF-1 receptor; IGF-I receptor; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor; insulin-like growth factor 1 receptor beta subunit
 UniProt Protein Name    Insulin-like growth factor 1 receptor
 UniProt Synonym Protein Names   
Insulin-like growth factor I receptor
 Protein Family    Insulin-like growth factor 1 receptor
 UniProt Gene Name    IGF1R [Similar Products]
 UniProt Entry Name    IGF1R_PIG
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 UniProt Comments for IGF1R    Function: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Cofactor: Manganese

Subunit structure: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 1 fibronectin type-III domain.Contains 1 protein kinase domain.
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Product References and Citations for anti-IGF1R antibody

   Xiong et al. (1992) Proc Natl Acad Sci USA 89: 5356; Li et al. (1993) Biochem Biophys Res Commun 196: 92.
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 Research Articles on IGF1R    1. mRNA expression of IGF-I receptor
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-IGF1R antibodyOrgans/Tissues associated with anti-IGF1R antibody
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Glioma Pathway antibodies  Glioma Pathway Diagram
 Glioma Pathway antibodies  Glioma Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >140 publications with IGF1R and Embryonic Tissue
 Placenta Antibodies  >78 publications with IGF1R and Placenta
 Spleen Antibodies  >15 publications with IGF1R and Spleen
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