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anti-IGF1 antibody :: Mouse IGF1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS530800
Western Blot (WB)
Unit / Price
0.2 mg  /  $550 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF1, Monoclonal Antibody

 Also Known As   

IGF1 antibody

 Product Synonym Names    Monoclonal IGF1; Anti-IGF1; IGF1; IGF 1; IGF-1; Insulin-Like Growth Factor-1
 Product Gene Name   

anti-IGF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P17647
 Clonality    Monoclonal
 Isotype    IgG1 kappa
 Clone Number    Sm1.2
 Host    Mouse
 Species Reactivity    Avian, Chicken, Mouse, Rat
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 Specificity    Human
 Purity/Purification    IGF1 antibody was purified by Ammonium sulfate precipitation.
 Form/Format    Lyophilized from 500ul of 0.1M tris-glycine, pH 7.4.
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 Biological Significance    Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 is produced primarily by the liver as an endocrine hormone and targets tissues in a paracrine/autocrine fashion.
 Immunogen    IGF1 antibody was raised in mouse using human insulin-like growth factor I as the immunogen.
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-IGF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IGF1 antibody

   Mouse monoclonal IGF1 antibody
 Product Categories/Family for anti-IGF1 antibody    Hormones & Steroids
 Applications Tested/Suitable for anti-IGF1 antibody   

Immunohistochemistry (IHC), Immunoprecipitation (IP), Neutralization, Western Blot (WB)

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 Western Blot (WB) of anti-IGF1 antibody    Western blot analysis of IGF1 probed with anti-IGF1 (0.5ug/ml).
anti-IGF1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IGF1. It may not necessarily be applicable to this product.
 NCBI GI #    290543535
 NCBI GeneID    100135551
 NCBI Accession #    NP_001166437.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172966.1 [Other Products]
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 UniProt Primary Accession #    P17647 [Other Products]
 UniProt Related Accession #    P17647 [Other Products]
 Molecular Weight    17 kDa (predicted detection band MW)
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 NCBI Official Full Name    insulin-like growth factor I
 NCBI Official Symbol    Igf1 [Similar Products]
 NCBI Protein Information    insulin-like growth factor I
 UniProt Protein Name    Insulin-like growth factor I
 UniProt Synonym Protein Names   
 Protein Family    Insulin-like growth factor
 UniProt Gene Name    IGF1 [Similar Products]
 UniProt Synonym Gene Names    IGF-I [Similar Products]
 UniProt Entry Name    IGF1_CAVPO
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 UniProt Comments for IGF1    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 ().
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 Research Articles on IGF1    1. Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IGF1 antibodyDiseases associated with anti-IGF1 antibody
 Reference Product  PubMed Publications
 IGF1R antibody  >468 publications with IGF1 and IGF1R
 IGFBP3 antibody  >236 publications with IGF1 and IGFBP3
 IGFBP1 antibody  >80 publications with IGF1 and IGFBP1
 IGFBP2 antibody  >65 publications with IGF1 and IGFBP2
 INSR antibody  >43 publications with IGF1 and INSR
 IGFBP5 antibody  >31 publications with IGF1 and IGFBP5
 IGFBP4 antibody  >26 publications with IGF1 and IGFBP4
 SHC1 antibody  >1 publications with IGF1 and SHC1
 INSRR antibody  >1 publications with IGF1 and INSRR
 Disease Name  Pubmed Publications
 Acromegaly Antibodies  >138 publications with IGF1 and Acromegaly
 Breast Neoplasms Antibodies  >115 publications with IGF1 and Breast Neoplasms
 Inflammation Antibodies  >92 publications with IGF1 and Inflammation
 Female Urogenital Diseases Antibodies  >88 publications with IGF1 and Female Urogenital Diseases
 Liver Diseases Antibodies  >72 publications with IGF1 and Liver Diseases
 Adenoma Antibodies  >67 publications with IGF1 and Adenoma
 Prostatic Neoplasms Antibodies  >56 publications with IGF1 and Prostatic Neoplasms
 Necrosis Antibodies  >49 publications with IGF1 and Necrosis
 Pituitary Neoplasms Antibodies  >48 publications with IGF1 and Pituitary Neoplasms
 Hypertension Antibodies  >41 publications with IGF1 and Hypertension
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