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anti-IL-1b antibody :: Mouse IL-1 beta Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140163 anti-IL-1b antibody
Unit / Price
0.5 mg  /  $280 +1 FREE 8GB USB
1 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-1 beta (IL-1b), Monoclonal Antibody

 Also Known As   

Mouse Anti Human IL-1 beta FITC

 Product Synonym Names    IL 1 Beta Antibody, FITC; Interleukin-1b, Mouse Anti-Human FITC; Catabolin; Lymphocyte-activating factor (LAF); Endogenous Pyrogen (EP); Leukocyte Endogenous Mediator (LEM); Mononuclear Cell Factor (MCF); IL1F2; IL-1 beta; IL-1b FITC
 Product Gene Name   

anti-IL-1b antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    NYR-hIL1
 Host    Mouse
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 Purity/Purification    Ion Exchange.
 Concentration    1 mg/ml in PBS (after reconstitution). (lot specific)
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 Reconstitution    Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
 Immunogen    r.Human IL-1b.
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 Preparation and Storage    In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
Antibody is shipped lyophilized at ambient temperature.
 Other Notes    Small volumes of anti-IL-1b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL-1b antibody

   Introduction: Interleukin-1b is produced by activated macrophages, IL-1B stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. IL1B proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
 Product Categories/Family for anti-IL-1b antibody    ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
 Applications Tested/Suitable for anti-IL-1b antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA), Immunoprecipitation (IP)

 Application Notes for anti-IL-1b antibody    Western Blot, immunohistochemistry intra-cellular staining and will also work in Direct ELISA and Immunoprecipitation.
For intra-cellular staining, 10 ul per 1,000,000 cells. By direct ELISA, 1:10,000 dilution will yield >1.0 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig.
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NCBI/Uniprot data below describe general gene information for IL-1b. It may not necessarily be applicable to this product.
 NCBI GI #    6680415
 NCBI GeneID    16176
 NCBI Accession #    NP_032387.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008361.3 [Other Products]
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 UniProt Secondary Accession #    Q2M4J6 [Other Products]
 UniProt Related Accession #    P10749 [Other Products]
 Molecular Weight    30,931 Da
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 NCBI Official Full Name    interleukin-1 beta
 NCBI Official Synonym Full Names    interleukin 1 beta
 NCBI Official Symbol    Il1b [Similar Products]
 NCBI Official Synonym Symbols   
Il-1b; IL-1beta
[Similar Products]
 NCBI Protein Information    interleukin-1 beta; IL-1 beta
 UniProt Protein Name    Interleukin-1 beta
 UniProt Gene Name    Il1b [Similar Products]
 UniProt Synonym Gene Names    IL-1 beta [Similar Products]
 UniProt Entry Name    IL1B_MOUSE
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 NCBI Summary for IL-1b    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]
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 UniProt Comments for IL-1b    IL1B: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Monomer. Belongs to the IL-1 family.

Protein type: Cytokine

Cellular Component: extracellular space; cell; extracellular region; intracellular; cytosol; vesicle; secretory granule

Molecular Function: protein domain specific binding; interleukin-1 receptor binding; cytokine activity; receptor binding

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; negative regulation of MAP kinase activity; positive regulation of JNK activity; positive regulation of nitric oxide biosynthetic process; negative regulation of glutamate secretion; positive regulation of apoptosis; activation of MAPK activity; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; germ cell programmed cell death; negative regulation of insulin receptor signaling pathway; positive regulation of glial cell differentiation; response to lipopolysaccharide; positive regulation of lipid catabolic process; positive regulation of NF-kappaB import into nucleus; fever; positive regulation of membrane protein ectodomain proteolysis; response to carbohydrate stimulus; activation of NF-kappaB transcription factor; elevation of cytosolic calcium ion concentration; positive regulation of phagocytosis; positive regulation of T cell proliferation; positive regulation of astrocyte differentiation; neutrophil chemotaxis; positive regulation of heterotypic cell-cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; positive regulation of interleukin-6 production; interleukin-1 beta production; social behavior; positive regulation of angiogenesis; negative regulation of neuron differentiation; positive regulation of cell division; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of lipid metabolic process; leukocyte migration; sequestering of triacylglycerol; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of stress-activated MAPK cascade; negative regulation of neurogenesis; positive regulation of interleukin-8 production; negative regulation of cell proliferation; negative regulation of lipid catabolic process; hyaluronan biosynthetic process; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; aging; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; positive regulation of immature T cell proliferation in the thymus; response to ATP; memory; positive regulation of interferon-gamma production; positive regulation of chemokine biosynthetic process; positive regulation of prostaglandin secretion; positive regulation of fever; immune response; positive regulation of protein amino acid phosphorylation; regulation of insulin secretion
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 Research Articles on IL-1b    1. Immune complexes inhibit IL-1 secretion and inflammasome activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL-1b antibodyPathways associated with anti-IL-1b antibody
 Reference Product  PubMed Publications
 Tnf antibody  >286 publications with IL-1b and Tnf
 Il6 antibody  >285 publications with IL-1b and Il6
 Il1a antibody  >196 publications with IL-1b and Il1a
 Casp1 antibody  >74 publications with IL-1b and Casp1
 Il1r1 antibody  >37 publications with IL-1b and Il1r1
 Il18 antibody  >34 publications with IL-1b and Il18
 Nfkb1 antibody  >26 publications with IL-1b and Nfkb1
 Myd88 antibody  >25 publications with IL-1b and Myd88
 Rela antibody  >19 publications with IL-1b and Rela
 Il1r2 antibody  >14 publications with IL-1b and Il1r2
 Products by Pathway  Pathway Diagram
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 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
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Diseases associated with anti-IL-1b antibodyOrgans/Tissues associated with anti-IL-1b antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >427 publications with IL-1b and Inflammation
 Necrosis Antibodies  >269 publications with IL-1b and Necrosis
 Skin Diseases Antibodies  >56 publications with IL-1b and Skin Diseases
 Stomach Neoplasms Antibodies  >43 publications with IL-1b and Stomach Neoplasms
 Hypersensitivity Antibodies  >27 publications with IL-1b and Hypersensitivity
 Arthritis, Rheumatoid Antibodies  >27 publications with IL-1b and Arthritis, Rheumatoid
 Adenocarcinoma Antibodies  >24 publications with IL-1b and Adenocarcinoma
 Asthma Antibodies  >22 publications with IL-1b and Asthma
 Myocardial Ischemia Antibodies  >21 publications with IL-1b and Myocardial Ischemia
 Colitis Antibodies  >20 publications with IL-1b and Colitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >351 publications with IL-1b and Blood
 Lung Antibodies  >80 publications with IL-1b and Lung
 Brain Antibodies  >64 publications with IL-1b and Brain
 Bone Marrow Antibodies  >37 publications with IL-1b and Bone Marrow
 Muscle Antibodies  >29 publications with IL-1b and Muscle
 Spleen Antibodies  >13 publications with IL-1b and Spleen
 Lymph Node Antibodies  >9 publications with IL-1b and Lymph Node
 Vagina Antibodies  >5 publications with IL-1b and Vagina
 Mammary Gland Antibodies  >5 publications with IL-1b and Mammary Gland
 Thymus Antibodies  >3 publications with IL-1b and Thymus
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