NP_002181.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,504 Da
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Synonym Symbols
IL17; CTLA8; IL-17; CTLA-8; IL-17A [Similar Products]
NCBI Protein Information
interleukin-17A
UniProt Protein Name
Interleukin-17A
UniProt Synonym Protein Names
Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
UniProt Synonym Gene Names
NCBI Summary for IL-17A
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for IL-17A
IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p12.2
Cellular Component: extracellular region
Molecular Function: protein binding
Biological Process: apoptosis; cell death; cell-cell signaling; immune response; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter
Research Articles on IL-17A
Precautions
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Disclaimer
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Products associated with anti-IL-17A antibody
Pathways associated with anti-IL-17A antibody
Diseases associated with anti-IL-17A antibody
Organs/Tissues associated with anti-IL-17A antibody
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