NP_665833.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,592 Da
NCBI Official Full Name
interleukin-17C
NCBI Official Synonym Full Names
interleukin 17C
NCBI Official Synonym Symbols
NCBI Protein Information
interleukin-17C
UniProt Protein Name
Interleukin-17C
UniProt Synonym Protein Names
Cytokine CX2
UniProt Synonym Gene Names
UniProt Comments for IL-17C
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NFKB and MAPK pathways. Acts synergically with IL22, TNF and IL1B in inducing antibacterial peptides. May have protective function by maintaining epithelial homeostasis after an inflammatory challenge, such as that caused in the intestine by dextran sulfate sodium in a colitis model. May also promote an inflammatory phenotype, such as skin in a psoriasis model. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, such as autoimmune encephalitis.
Research Articles on IL-17C
Precautions
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Disclaimer
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Products associated with anti-IL-17C antibody
Pathways associated with anti-IL-17C antibody
Diseases associated with anti-IL-17C antibody
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