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anti-IL-23 receptor antibody :: Rat anti-Mouse IL-23 receptor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690333 anti-IL-23 receptor antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-23 receptor, Monoclonal Antibody

 Also Known As   

Rat Anti-Mouse IL-23 receptor

 Product Synonym Names    Anti-mouse Interleukin-23 Receptor (#6D34)
 Product Gene Name   

anti-IL-23 receptor antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000072.6 (67422932..67491855, complement). Location: 6 C1; 6
 3D Structure    ModBase 3D Structure for Q8K4B4
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    (6D34)
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    This antibody detects mouse IL-23R in Western blotting.
 Purity/Purification    Protein A/G affinity chromatography
 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of IL-23R extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
 Antigen    Mouse recombinant EC domain of IL-23 R
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-IL-23 receptor antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IL-23 receptor antibody

   The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 R shares structural features with the IL-12 R beta 2, including an N-terminal Ig-like domain, two cytokine receptor domains and multiple glycosylation sites in the extracellular domain. IL-23 R lacks the three extracellular membrane-proximal fibronectin-type III domains present on IL-12 R beta 2.
 Applications Tested/Suitable for anti-IL-23 receptor antibody   

Western Blot (WB)

 Application Notes for anti-IL-23 receptor antibody    1. Western blot: Yes (1:500-1000)
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NCBI/Uniprot data below describe general gene information for IL-23 receptor. It may not necessarily be applicable to this product.
 NCBI GI #    239052137
 NCBI GeneID    209590
 NCBI Accession #    NP_653131.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_144548.1 [Other Products]
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 UniProt Primary Accession #    Q8K4B4 [Other Products]
 UniProt Related Accession #    Q8K4B4 [Other Products]
 Molecular Weight    73,453 Da
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 NCBI Official Full Name    interleukin-23 receptor
 NCBI Official Synonym Full Names    interleukin 23 receptor
 NCBI Official Symbol    Il23r [Similar Products]
 NCBI Official Synonym Symbols   
IL-23R
[Similar Products]
 NCBI Protein Information    interleukin-23 receptor; IL-23 receptor
 UniProt Protein Name    Interleukin-23 receptor
 UniProt Gene Name    Il23r [Similar Products]
 UniProt Synonym Gene Names    IL-23 receptor; IL-23R [Similar Products]
 UniProt Entry Name    IL23R_MOUSE
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 UniProt Comments for IL-23 receptor    Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis

By similarity.

Subunit structure: Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3

By similarity.

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Expressed by Th1, Th2 and dendritic cells. Ref.1

Post-translational modification: Phosphorylated in response to IL23

By similarity.

Sequence similarities: Belongs to the type I cytokine receptor family. Type 2 subfamily.Contains 2 fibronectin type-III domains.
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 Research Articles on IL-23 receptor    1. the balance between the enhancing and inhibitory effects of gamma-delta T cells is regulated by their level of IL-23R expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL-23 receptor antibodyPathways associated with anti-IL-23 receptor antibody
 Reference Product  PubMed Publications
 Il23a antibody  >21 publications with IL-23 receptor and Il23a
 Jak2 antibody  >16 publications with IL-23 receptor and Jak2
 Il21 antibody  >13 publications with IL-23 receptor and Il21
 Il12rb1 antibody  >12 publications with IL-23 receptor and Il12rb1
 Il6 antibody  >9 publications with IL-23 receptor and Il6
 Tyk2 antibody  >7 publications with IL-23 receptor and Tyk2
 Tbx21 antibody  >6 publications with IL-23 receptor and Tbx21
 Socs3 antibody  >2 publications with IL-23 receptor and Socs3
 Socs1 antibody  >1 publications with IL-23 receptor and Socs1
 Jak1 antibody  >1 publications with IL-23 receptor and Jak1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with anti-IL-23 receptor antibody
 Disease Name  Pubmed Publications
 Inflammatory Bowel Diseases Antibodies  >183 publications with IL-23 receptor and Inflammatory Bowel Diseases
 Crohn Disease Antibodies  >123 publications with IL-23 receptor and Crohn Disease
 Colitis, Ulcerative Antibodies  >91 publications with IL-23 receptor and Colitis, Ulcerative
 Arthritis Antibodies  >91 publications with IL-23 receptor and Arthritis
 Psoriasis Antibodies  >79 publications with IL-23 receptor and Psoriasis
 Inflammation Antibodies  >68 publications with IL-23 receptor and Inflammation
 Spondylitis, Ankylosing Antibodies  >54 publications with IL-23 receptor and Spondylitis, Ankylosing
 Inflammatory Bowel Disease 17 Antibodies  >41 publications with IL-23 receptor and Inflammatory Bowel Disease 17
 Necrosis Antibodies  >25 publications with IL-23 receptor and Necrosis
 Liver Diseases Antibodies  >8 publications with IL-23 receptor and Liver Diseases
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