NP_758525.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interleukin-25 isoform 2
NCBI Official Synonym Full Names
interleukin 25
NCBI Official Synonym Symbols
NCBI Protein Information
interleukin-25; interleukin-17E
UniProt Protein Name
Interleukin-25
UniProt Synonym Protein Names
Interleukin-17E
UniProt Synonym Gene Names
UniProt Entry Name
IL25_HUMAN
NCBI Summary for IL25
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Comments for IL25
Function: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
Subcellular location: Secreted.
Tissue specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
Sequence similarities: Belongs to the IL-17 family.
Product References and Citations for anti-IL25 antibody
1) Kleinschek, M.A. et al. (2007). J. Exp. Med. 204:161-70. 3) Fort, M.M. et al. (2001). Immunity. 15:985-95. 4) Owyang, A.M. et al. (2006). J. Exp. Med. 203:1105-16. 5) Stock, P. et al. (2009). J. Immunol. 182:5116-22. 6) Perrigoue, J.G. et al. (2008). Cell Microbiol. 10:1757-64.
Research Articles on IL25
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Products associated with anti-IL25 antibody
Pathways associated with anti-IL25 antibody
Diseases associated with anti-IL25 antibody
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