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anti-IL4R antibody :: Mouse IL-4 RECEPTOR Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS211332 anti-IL4R antibody
Unit / Price
0.1 mg  /  $590 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-4 RECEPTOR (IL4R), Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN INTERLEUKIN-4 RECEPTOR

 Product Gene Name   

anti-IL4R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147781
 3D Structure    ModBase 3D Structure for P24394
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    25463 (49/20)
 Host    Mouse
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 Specificity    This item is specific for human interleukin 4 receptor, the transmembrane ligand-binding subunit of the heterodimeric IL-4 receptor complex. IL-4 R is expressed by B cells, T cells, monocytes and macrophages.Clone 25463 is reported to block human cell surface IL-4 receptor mediated bioactivities induced by IL-4 or IL-13. An ND50 was observed at approximately 5-20 ng/ml in the presence of 0.2 ng/ml of IL-4 using the factor dependant human erythroleukemic cell line, TF-1.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
10% Trehalose
Preparation
 Immunogen    Sf 21-derived, recombinant human interleukin 4 receptor, extracellular domain.
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-IL4R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL4R antibody

   MBS211332 is specific for human interleukin 4 receptor, the transmembrane ligand-binding subunit of the heterodimeric IL-4 receptor complex. IL-4 R is expressed by B cells, T cells, monocytes and macrophages. Clone 25463 is reported to block human cell surface IL-4 receptor mediated bioactivities induced by IL-4 or IL-13. An ND50 was observed at approximately 5-20 ng/ml in the presence of 0.2 ng/ml of IL-4 using the factor dependant human erythroleukemic cell line, TF-1.
 Applications Tested/Suitable for anti-IL4R antibody   

ELISA (EIA), Flow cytometry (FC/FACS), Immunohistology Paraffin, Western Blot (WB)*

 Application Notes for anti-IL4R antibody    ELISA: Minimum Dilution: 1/500; Maximum Dilution: 1/2000;
Flow Cytometry: Minimum Dilution: 1/20; Maximum Dilution: 1/80;
Immunohistology - Paraffin: Minimum Dilution: 1/40; Maximum Dilution: 1/125;
Western Blotting: Minimum Dilution: 1/250; Maximum Dilution: 1/1000; Application Note: 0100-0462 detects human IL-4 R under non-reducing conditions.
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NCBI/Uniprot data below describe general gene information for IL4R. It may not necessarily be applicable to this product.
 NCBI GI #    4557669
 NCBI GeneID    3566
 NCBI Accession #    NP_000409.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000418.3 [Other Products]
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 UniProt Primary Accession #    P24394 [Other Products]
 UniProt Secondary Accession #    Q96P01; Q9H181; Q9H182; Q9H183; Q9H184; Q9H185; Q9H186; Q9H187; B4E076; B9EKU8; H3BSY5 [Other Products]
 UniProt Related Accession #    P24394 [Other Products]
 Molecular Weight    88,267 Da [Similar Products]
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 NCBI Official Full Name    interleukin-4 receptor subunit alpha isoform a
 NCBI Official Synonym Full Names    interleukin 4 receptor
 NCBI Official Symbol    IL4R [Similar Products]
 NCBI Official Synonym Symbols   
CD124; IL4RA; IL-4RA
[Similar Products]
 NCBI Protein Information    interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin-4 receptor alpha chain
 UniProt Protein Name    Interleukin-4 receptor subunit alpha
 UniProt Synonym Protein Names   
CD_antigen: CD124Soluble interleukin-4 receptor subunit alpha; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; sIL4Ralpha/protAlternative name(s):IL-4-binding protein; IL4-BP
 Protein Family    Interleukin-4 receptor
 UniProt Gene Name    IL4R [Similar Products]
 UniProt Synonym Gene Names    IL4RA; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; sIL4Ralpha/prot; IL4-BP [Similar Products]
 UniProt Entry Name    IL4RA_HUMAN
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 NCBI Summary for IL4R    This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
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 UniProt Comments for IL4R    IL4R: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 16p12.1-p11.2

Cellular Component: extracellular space; integral to plasma membrane; receptor complex

Molecular Function: protein binding; receptor signaling protein activity; interleukin-4 receptor activity

Biological Process: ovulation; positive regulation of T-helper 2 cell differentiation; negative regulation of T-helper 1 cell differentiation; production of molecular mediator of acute inflammatory response; response to estrogen stimulus; immune response; signal transduction; defense response to protozoan; positive regulation of macrophage activation; regulation of cell proliferation

Disease: Ige Responsiveness, Atopic; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on IL4R    1. increased expression in B cells of patients with house dust mites allergic asthma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-IL4R antibodyDiseases associated with anti-IL4R antibody
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 IL-4 Signaling Pathway antibodies  IL-4 Signaling Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >38 publications with IL4R and Inflammation
 Nervous System Diseases Antibodies  >22 publications with IL4R and Nervous System Diseases
 Necrosis Antibodies  >17 publications with IL4R and Necrosis
 Cardiovascular Diseases Antibodies  >10 publications with IL4R and Cardiovascular Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >8 publications with IL4R and Drug-Related Side Effects and Adverse Reactions
 Kidney Diseases Antibodies  >6 publications with IL4R and Kidney Diseases
 Breast Neoplasms Antibodies  >6 publications with IL4R and Breast Neoplasms
 Leukemia Antibodies  >6 publications with IL4R and Leukemia
 HIV Infections Antibodies  >6 publications with IL4R and HIV Infections
 Neoplasms, Experimental Antibodies  >5 publications with IL4R and Neoplasms, Experimental
Organs/Tissues associated with anti-IL4R antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >79 publications with IL4R and Blood
 Skin Antibodies  >13 publications with IL4R and Skin
 Brain Antibodies  >9 publications with IL4R and Brain
 Lung Antibodies  >8 publications with IL4R and Lung
 Vascular Antibodies  >7 publications with IL4R and Vascular
 Kidney Antibodies  >6 publications with IL4R and Kidney
 Bone Antibodies  >6 publications with IL4R and Bone
 Liver Antibodies  >4 publications with IL4R and Liver
 Lymph Node Antibodies  >3 publications with IL4R and Lymph Node
 Heart Antibodies  >3 publications with IL4R and Heart
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