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anti-Il6 antibody :: Rat anti-Human IL-6 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS670046 anti-Il6 antibody
Unit / Price
0.5 mg  /  $270 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL-6 (Il6), Monoclonal Antibody

★Popular Item★
 Also Known As   

Rat Anti-Human IL-6-UNLB

 Product Synonym Names    Rat Anti-Human IL-6 - Purified, Unlabeled Antibody; Rat Anti-Human IL-6
 Product Gene Name   

anti-Il6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_005103.2 (456799..461376, complement). Location: 4q11
 3D Structure    ModBase 3D Structure for P20607
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 Clonality    Monoclonal
 Isotype    Rat IgG2a, kappa
 Clone Number    MQ2-39C3
 Host    Rat
 Species Reactivity    Human
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 Specificity    Human Interleukin-6 (IL-6)1-3 This is a neutralizing antibody.
 Form/Format    Purified (UNLB) Antibody
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 Immunogen    COS-7-expressed recombinant human IL-6
 Characterization    To ensure acceptable performance, each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg labeled antibody in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
Reagents are stable for the period shown on the label if stored as directed.
 Other Notes    Small volumes of anti-Il6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Il6 antibody   

ELISA; Immunoprecipitation; Western Blot

 Application Notes for anti-Il6 antibody    Research Application(s): ELISA Detection: MQ2-39C3 monoclonal antibody is useful as a detection antibody in a sandwich ELISA for quantifying human IL-6 protein levels.1-3 Biotinylated MQ2-39C3 antibody should be paired with purified MQ2-13A5 antibody as the capture antibody, with purified recombinant human IL-6 as the standard.
Western Blotting: The purified MQ2-39C3 antibody is also useful for immunoprecipitation and Western blotting applications. For Western blotting, a concentration of 1-5 ug/mL (in conjunction with AP-labeled Goat Anti-Rat-Ig) has been found to enable detection of <= 100 ng/lane of recombinant human IL-6 under reducing conditions.
Since applications vary, each investigator should determine the optimal concentration appropriate for individual applications.
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NCBI/Uniprot data below describe general gene information for Il6. It may not necessarily be applicable to this product.
 NCBI GI #    7549769
 NCBI GeneID    24498
 NCBI Accession #    NP_036721.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012589.1 [Other Products]
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 UniProt Primary Accession #    P20607 [Other Products]
 UniProt Related Accession #    P20607 [Other Products]
 Molecular Weight    24,357 Da [Similar Products]
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 NCBI Official Full Name    interleukin-6
 NCBI Official Synonym Full Names    interleukin 6
 NCBI Official Symbol    Il6 [Similar Products]
 NCBI Official Synonym Symbols   
ILg6; Ifnb2
[Similar Products]
 NCBI Protein Information    interleukin-6; IL-6; Interleukin 6 (interferon, beta 2)
 UniProt Protein Name    Interleukin-6
 Protein Family    Interleukin
 UniProt Gene Name    Il6 [Similar Products]
 UniProt Synonym Gene Names    Il-6 [Similar Products]
 UniProt Entry Name    IL6_RAT
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 NCBI Summary for Il6    a cytokine involved in development and possibly in neurodegenerative processes [RGD]
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 UniProt Comments for Il6    Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-6 superfamily.
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Product References and Citations for anti-Il6 antibody

   1. Abrams, J.S., M.-G. Roncarolo, H.. Yssel, U. Andersson, G.J. Gleich, and J.E., Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5-24.
2. Abrams, J. 1995. Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. In Current Protocols in Immunology (J. Coligamn, A. Kruisbeek, D. Margulies, E. Shevach, W. Strober, eds.). John Wiley and Sons, New York. Unit 6.20.
3. Gaines Das, R., and S. Poole. 1993. The international standard for IL-6. Evaluation in an international collaborative study. J. Immunol. Meth. 160:147.
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 Research Articles on Il6    1. Data identify IL-6 as an important target for modulation of autoimmune responses.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Il6 antibodyDiseases associated with anti-Il6 antibody
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1069 publications with Il6 and Inflammation
 Neoplasms Antibodies  >539 publications with Il6 and Neoplasms
 Cardiovascular Diseases Antibodies  >454 publications with Il6 and Cardiovascular Diseases
 Lung Diseases Antibodies  >177 publications with Il6 and Lung Diseases
 Leukemia Antibodies  >133 publications with Il6 and Leukemia
 Atherosclerosis Antibodies  >126 publications with Il6 and Atherosclerosis
 Liver Diseases Antibodies  >123 publications with Il6 and Liver Diseases
 Obesity Antibodies  >122 publications with Il6 and Obesity
 Insulin Resistance Antibodies  >101 publications with Il6 and Insulin Resistance
 Kidney Diseases Antibodies  >98 publications with Il6 and Kidney Diseases
Organs/Tissues associated with anti-Il6 antibody
 Organ/Tissue Name  Pubmed Publications
 Uncharacterized Tissue Antibodies  >1 publications with Il6 and Uncharacterized Tissue
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