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anti-IL12 antibody :: Mouse anti-Human IL-12 IL12 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531022 anti-IL12 antibody
Unit / Price
0.5 mg  /  $490 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL12, Monoclonal Antibody

 Also Known As   

IL12 antibody

 Product Synonym Names    Monoclonal IL12; Anti-IL12; CTL maturation factor; Cytotoxic lymphocyte maturation factor; Interleukin 12; TSF; IL-12; CLMF; TCMF; NKSF; IL 12; IL12
 Product Gene Name   

anti-IL12 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601604
 3D Structure    ModBase 3D Structure for P42701
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 Clonality    Monoclonal
 Isotype    IgG1 kappa
 Clone Number    M12
 Host    Mouse
 Species Reactivity    Human IL-12
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 Form/Format    Lyophilized from PBS.
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 Biological Significance    IL12 is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells.
 Immunogen    IL12 antibody was raised in mouse using highly pure recombinant human IL-12 as the immunogen.
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 Preparation and Storage    Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-IL12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL12 antibody

   Mouse monoclonal IL12 antibody
 Product Categories/Family for anti-IL12 antibody    Cytokines & Growth Factors
 Applications Tested/Suitable for anti-IL12 antibody   

ELISA (EIA), Inhibition, Western Blot (WB)

 Application Notes for anti-IL12 antibody    ELISA: 2-4 ug/ml
WB: 0.5-1 ug/ml
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NCBI/Uniprot data below describe general gene information for IL12. It may not necessarily be applicable to this product.
 NCBI GI #    5031785
 NCBI GeneID    3594
 NCBI Accession #    NP_005526.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005535.1 [Other Products]
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 UniProt Primary Accession #    P42701 [Other Products]
 UniProt Secondary Accession #    Q8N6Q7; A8K308; B2RPF1; B7ZKK3 [Other Products]
 UniProt Related Accession #    P42701 [Other Products]
 Molecular Weight    75 kDa (predicted detection band MW)
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 NCBI Official Full Name    interleukin-12 receptor subunit beta-1 isoform 1
 NCBI Official Synonym Full Names    interleukin 12 receptor, beta 1
 NCBI Official Symbol    IL12RB1 [Similar Products]
 NCBI Official Synonym Symbols   
CD212; IMD30; IL12RB; IL-12R-BETA1
[Similar Products]
 NCBI Protein Information    interleukin-12 receptor subunit beta-1
 UniProt Protein Name    Interleukin-12 receptor subunit beta-1
 UniProt Synonym Protein Names   
IL-12 receptor beta component; CD_antigen: CD212
 UniProt Gene Name    IL12RB1 [Similar Products]
 UniProt Synonym Gene Names    IL12R; IL12RB; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1 [Similar Products]
 UniProt Entry Name    I12R1_HUMAN
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 NCBI Summary for IL12    The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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 UniProt Comments for IL12    IL12RB1: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Defects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type I cytokine receptor family. Type 2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-12 receptor activity; interleukin-23 binding; interleukin-23 receptor activity; interleukin-12 receptor binding

Biological Process: positive regulation of memory T cell differentiation; positive regulation of interferon-gamma production; peptidyl-tyrosine phosphorylation; positive regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; signal transduction; positive regulation of defense response to virus by host; positive regulation of activated T cell proliferation

Disease: Immunodeficiency 30
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 Research Articles on IL12    1. Genetic variations of IL-12B, IL-12Rbeta1, IL-12Rbeta2 in Behcet's disease and VKH syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL12 antibodyPathways associated with anti-IL12 antibody
 Reference Product  PubMed Publications
 IL12RB2 antibody  >53 publications with IL12 and IL12RB2
 IL12B antibody  >40 publications with IL12 and IL12B
 STAT1 antibody  >31 publications with IL12 and STAT1
 STAT4 antibody  >24 publications with IL12 and STAT4
 IL23A antibody  >18 publications with IL12 and IL23A
 IL23R antibody  >16 publications with IL12 and IL23R
 STAT3 antibody  >15 publications with IL12 and STAT3
 IL12A antibody  >14 publications with IL12 and IL12A
 IFNG antibody  >10 publications with IL12 and IFNG
 TYK2 antibody  >10 publications with IL12 and TYK2
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with anti-IL12 antibodyOrgans/Tissues associated with anti-IL12 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >39 publications with IL12 and Immune System Diseases
 Inflammation Antibodies  >29 publications with IL12 and Inflammation
 Mycobacterium Infections, Nontuberculous Antibodies  >18 publications with IL12 and Mycobacterium Infections, Nontuberculous
 Necrosis Antibodies  >14 publications with IL12 and Necrosis
 Disease Models, Animal Antibodies  >7 publications with IL12 and Disease Models, Animal
 Carcinoma Antibodies  >4 publications with IL12 and Carcinoma
 Liver Diseases Antibodies  >4 publications with IL12 and Liver Diseases
 Vascular Diseases Antibodies  >3 publications with IL12 and Vascular Diseases
 Dermatitis Antibodies  >3 publications with IL12 and Dermatitis
 Kidney Diseases Antibodies  >2 publications with IL12 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >91 publications with IL12 and Blood
 Lymph Node Antibodies  >17 publications with IL12 and Lymph Node
 Lymph Antibodies  >17 publications with IL12 and Lymph
 Skin Antibodies  >16 publications with IL12 and Skin
 Lung Antibodies  >11 publications with IL12 and Lung
 Spleen Antibodies  >9 publications with IL12 and Spleen
 Bone Marrow Antibodies  >6 publications with IL12 and Bone Marrow
 Bone Antibodies  >6 publications with IL12 and Bone
 Liver Antibodies  >5 publications with IL12 and Liver
 Kidney Antibodies  >3 publications with IL12 and Kidney
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