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anti-IL18R1 antibody :: Mouse anti-Human IL18R1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS632453 anti-IL18R1 antibody
Unit / Price
100 Tests  /  $740 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL18R1, Monoclonal Antibody

 Also Known As   

IL18R1 (Interleukin 18 Receptor 1, IL-18R-1, IL-18R1, CD218 Antigen-like Family Member A, CDw218a, IL1 Receptor-related Protein, IL-1Rrp, IL1R-rp, CD218a, IL1RRP) (PerCP)

 Product Synonym Names    Anti -IL18R1 (Interleukin 18 Receptor 1, IL-18R-1, IL-18R1, CD218 Antigen-like Family Member A, CDw218a, IL1 Receptor-related Protein, IL-1Rrp, IL1R-rp, CD218a, IL1RRP) (PerCP)
 Product Gene Name   

anti-IL18R1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (102979097..103015218). Location: 2q12
 OMIM    604494
 3D Structure    ModBase 3D Structure for Q13478
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    10K20
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human IL-18 R-a.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in 1ml saline, 0.5% BSA, 0.1% sodium azide. Labeled with Labeled with Peridinin-chlorophyll-protein complex (PerCP).
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 Immunogen    NS0-derived, recombinant human IL-18 R-a (aa20-329; Accession #Q13478).
 Hybridoma    Fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, NS0-derived, recombinant human IL-18 R-a.
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 Preparation and Storage    May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degree C. Freezing PerCP conjugates will result in a substantial loss of activity. PerCP conjugates are sensitive to light.
 Other Notes    Small volumes of anti-IL18R1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL18R1 antibody

   Interleukin 18 receptor alpha (IL-18 Ra) is a member of the IL-1 receptor superfamily and has been designated IL-1 R5. Along with IL-1 R7, it forms a heterodimeric receptor for IL-18. temperature.
 Product Categories/Family for anti-IL18R1 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-IL18R1 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-IL18R1 antibody    Suitable for use in Flow Cytometry.
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NCBI/Uniprot data below describe general gene information for IL18R1. It may not necessarily be applicable to this product.
 NCBI GI #    4504655
 NCBI GeneID    8809
 NCBI Accession #    NP_003846.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003855.2 [Other Products]
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 UniProt Primary Accession #    Q13478 [Other Products]
 UniProt Secondary Accession #    Q52LC9; B2R9Y5 [Other Products]
 UniProt Related Accession #    Q13478; Q86YL8 [Other Products]
 Molecular Weight    62,304 Da [Similar Products]
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 NCBI Official Full Name    interleukin-18 receptor 1
 NCBI Official Synonym Full Names    interleukin 18 receptor 1
 NCBI Official Symbol    IL18R1 [Similar Products]
 NCBI Official Synonym Symbols   
CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp
[Similar Products]
 NCBI Protein Information    interleukin-18 receptor 1; IL-18R1; IL1R-rp; IL-18R-1; cytokine receptor; OTTHUMP00000161340; OTTHUMP00000203113; IL1 receptor-related protein; CD218 antigen-like family member A
 UniProt Protein Name    Interleukin-18 receptor 1
 UniProt Synonym Protein Names   
CD218 antigen-like family member A; CDw218a; IL1 receptor-related protein
 Protein Family    Interleukin-18 receptor
 UniProt Gene Name    IL18R1 [Similar Products]
 UniProt Synonym Gene Names    IL1RRP [Similar Products]
 UniProt Entry Name    IL18R_HUMAN
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 NCBI Summary for IL18R1    The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq]
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 UniProt Comments for IL18R1    IL18R1: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. Belongs to the interleukin-1 receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; receptor activity; interleukin-1 receptor activity; interleukin-18 receptor activity

Biological Process: positive regulation of interferon-gamma production; T-helper 1 cell differentiation; natural killer cell activation; immune response; positive regulation of NF-kappaB import into nucleus; signal transduction
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 Research Articles on IL18R1    1. The levels of plasma IL-18 and IL-18R on CD3(+) lymphocytes were significantly increased in active phase immune thrombocytopenia than in remission phase and controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL18R1 antibodyPathways associated with anti-IL18R1 antibody
 Reference Product  PubMed Publications
 IL18 antibody  >198 publications with IL18R1 and IL18
 IL1RAP antibody  >5 publications with IL18R1 and IL1RAP
 CD48 antibody  >1 publications with IL18R1 and CD48
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL12 Signaling Mediated By STAT4 Pathway antibodies  IL12 Signaling Mediated By STAT4 Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
Diseases associated with anti-IL18R1 antibodyOrgans/Tissues associated with anti-IL18R1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >49 publications with IL18R1 and Inflammation
 Neoplasms Antibodies  >22 publications with IL18R1 and Neoplasms
 Necrosis Antibodies  >21 publications with IL18R1 and Necrosis
 Liver Diseases Antibodies  >8 publications with IL18R1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >8 publications with IL18R1 and Cardiovascular Diseases
 Inflammatory Bowel Diseases Antibodies  >7 publications with IL18R1 and Inflammatory Bowel Diseases
 Vascular Diseases Antibodies  >7 publications with IL18R1 and Vascular Diseases
 Psoriasis Antibodies  >5 publications with IL18R1 and Psoriasis
 Skin Diseases Antibodies  >5 publications with IL18R1 and Skin Diseases
 Kidney Diseases Antibodies  >4 publications with IL18R1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >15 publications with IL18R1 and Spleen
 Lung Antibodies  >9 publications with IL18R1 and Lung
 Liver Antibodies  >9 publications with IL18R1 and Liver
 Intestine Antibodies  >8 publications with IL18R1 and Intestine
 Bone Marrow Antibodies  >7 publications with IL18R1 and Bone Marrow
 Lymph Node Antibodies  >4 publications with IL18R1 and Lymph Node
 Ovary Antibodies  >3 publications with IL18R1 and Ovary
 Stomach Antibodies  >1 publications with IL18R1 and Stomach
 Thymus Antibodies  >1 publications with IL18R1 and Thymus
 Prostate Antibodies  >1 publications with IL18R1 and Prostate
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