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anti-IL33 antibody :: Mouse anti-Human IL33 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200087
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL33, Monoclonal Antibody

★Popular Item★
 Also Known As   

IL33 antibody

 Product Synonym Names    Interleukin 33; DVS27; NF-HEV; NKHEV; C9orf26; IL-33; Interleukin 33 CHROMOSOME 9 OPEN READING FRAME 26; DKFZp586H0523; DVS27 related protein; IL 1F11; IL 33; IL1F11; Interleukin 1 family member 11; INTERLEuKIN 33 NFHEV; Interleukin 33 precursor; Interleukin33; NF HEV; NFHEV; Nuclear factor from high endothelial venules; RP11 575C20.2; il33
 Product Gene Name   

anti-IL33 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AB024518 mRNA
 3D Structure    ModBase 3D Structure for O95760
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 Clonality    Monoclonal
 Isotype    IgG2b, k
 Clone Number    4E9
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human IL-33 (112-270aa) purified from E. coli
 Clone Note    Anti-human IL-33 mAb, clone 4E9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IL-33 protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-IL33 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL33 antibody

   Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.
 Product Categories/Family for anti-IL33 antibody    Hormones & Cytokines
 Applications Tested/Suitable for anti-IL33 antibody   

ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-IL33 antibody    WB: 1:500 ~ 1,000.
Recommended starting dilution is 1:500.
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 Western Blot (WB) of anti-IL33 antibody    The Cell lysates of 293T (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human IL-33 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. The Cell lysates of Jurkat (35ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human IL-33 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
anti-IL33 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-IL33 antibody    ICC/IF analysis of IL-33 in Jurkat cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human IL-33 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
anti-IL33 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for IL33. It may not necessarily be applicable to this product.
 NCBI GI #    15559209
 NCBI GeneID    90865
 NCBI Accession #    NP_254274 [Other Products]
 NCBI GenBank Nucleotide #    NM_033439.3 [Other Products]
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 UniProt Primary Accession #    O95760 [Other Products]
 UniProt Secondary Accession #    Q2YEJ5; B2R8L1; B4DJ35; B4E1Q9; D3DRI5; E7EAX4 [Other Products]
 UniProt Related Accession #    O95760 [Other Products]
 Molecular Weight    16,250 Da
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 NCBI Official Full Name    interleukin-33 isoform a
 NCBI Official Synonym Full Names    interleukin 33
 NCBI Official Symbol    IL33 [Similar Products]
 NCBI Official Synonym Symbols   
DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26
[Similar Products]
 NCBI Protein Information    interleukin-33
 UniProt Protein Name    Interleukin-33
 UniProt Synonym Protein Names   
Interleukin-1 family member 11; IL-1F11
 Protein Family    Interleukin
 UniProt Gene Name    IL33 [Similar Products]
 UniProt Synonym Gene Names    C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV [Similar Products]
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 NCBI Summary for IL33    The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
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 UniProt Comments for IL33    Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).
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Product References and Citations for anti-IL33 antibody

   Brint Ek, et al., (2005) J Biol Chem. 20:277 (51); Schmitz, et al., (2005) immunity. 23:479; Baekkevold ES, et al., (2003) Am.J.Pathol. 163 (1):69-90
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 Research Articles on IL33    1. Data suggest that interleukin-33 (IL-33) isoforms activate basophils and mast cells to drive type 2 inflammation in chronic stable asthma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL33 antibodyPathways associated with anti-IL33 antibody
 Reference Product  PubMed Publications
 IL1RL1 antibody  >404 publications with IL33 and IL1RL1
 IL13 antibody  >122 publications with IL33 and IL13
 TSLP antibody  >103 publications with IL33 and TSLP
 IL18 antibody  >47 publications with IL33 and IL18
 IL6 antibody  >31 publications with IL33 and IL6
 IL4 antibody  >26 publications with IL33 and IL4
 IL5 antibody  >21 publications with IL33 and IL5
 GATA3 antibody  >16 publications with IL33 and GATA3
 IL17A antibody  >12 publications with IL33 and IL17A
 USP21 antibody  >1 publications with IL33 and USP21
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Deubiquitination Pathway antibodies  Deubiquitination Pathway Diagram
 Development And Heterogeneity Of The ILC Family Pathway antibodies  Development And Heterogeneity Of The ILC Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with anti-IL33 antibodyOrgans/Tissues associated with anti-IL33 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >711 publications with IL33 and Inflammation
 Asthma Antibodies  >312 publications with IL33 and Asthma
 Lung Diseases Antibodies  >287 publications with IL33 and Lung Diseases
 Hypersensitivity, Immediate Antibodies  >268 publications with IL33 and Hypersensitivity, Immediate
 Disease Models, Animal Antibodies  >203 publications with IL33 and Disease Models, Animal
 Necrosis Antibodies  >168 publications with IL33 and Necrosis
 Cardiovascular Diseases Antibodies  >134 publications with IL33 and Cardiovascular Diseases
 Fibrosis Antibodies  >90 publications with IL33 and Fibrosis
 Heart Diseases Antibodies  >74 publications with IL33 and Heart Diseases
 Dermatitis, Atopic Antibodies  >59 publications with IL33 and Dermatitis, Atopic
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >274 publications with IL33 and Lung
 Skin Antibodies  >130 publications with IL33 and Skin
 Heart Antibodies  >119 publications with IL33 and Heart
 Vascular Antibodies  >94 publications with IL33 and Vascular
 Liver Antibodies  >88 publications with IL33 and Liver
 Intestine Antibodies  >73 publications with IL33 and Intestine
 Brain Antibodies  >71 publications with IL33 and Brain
 Muscle Antibodies  >67 publications with IL33 and Muscle
 Connective Tissue Antibodies  >39 publications with IL33 and Connective Tissue
 Kidney Antibodies  >31 publications with IL33 and Kidney
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