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anti-IL6 antibody :: Mouse anti-Human IL6 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245031
Immunohistochemistry (IHC)
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL6, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 6D9A1,6C12B1] (IgG1) to Human IL6

 Product Synonym Names    Anti-IL6 Antibody (clone 6D9A1,6C12B1) IHC-plus; IL6; B-cell stimulatory factor 2; BSF-2; BSF2; CTL differentiation factor; Hybridoma growth factor; IFN-beta-2; Interleukin-6; Interferon beta-2; Interleukin BSF-2; IFNB2; B-cell differentiation factor; CDF; HSF; IL-6; Human IL6
 Product Gene Name   

anti-IL6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 604302
 3D Structure    ModBase 3D Structure for P05231
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    6D9A1; 6C12B1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Ni-NTA purified recombinant human IL-6 expressed in E Coli strain BL21 (DE3)
 Purity/Purification    Ascites
 Form/Format    Ascitic fluid, 0.03% sodium azide.
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 Target Species    Human
 Immunogen Description    Recombinant human IL6 / IL-6.
 Immunogen Type    Recombinant protein
 Immunogen    IL6 antibody was raised against recombinant human IL6 / IL-6.
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-IL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL6 antibody

   Interleukin-6 (IL6) is a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this IL6 is implicated in a wide variety of inflammation-associated disease states, including susceptibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
 Product Categories/Family for anti-IL6 antibody    Family: Hormone
 Applications Tested/Suitable for anti-IL6 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-IL6 antibody    ELISA (1:10000), IHC-P (1:200), WB (1:200 - 1:1000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-IL6 antibody    Anti-IL-6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
anti-IL6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IL6. It may not necessarily be applicable to this product.
 NCBI GI #    10834984
 NCBI GeneID    3569
 NCBI Accession #    NP_000591.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000600.3 [Other Products]
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 UniProt Primary Accession #    P05231 [Other Products]
 UniProt Secondary Accession #    Q9UCU2; Q9UCU3; Q9UCU4 [Other Products]
 UniProt Related Accession #    P05231 [Other Products]
 Molecular Weight    23,718 Da
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 NCBI Official Full Name    interleukin-6
 NCBI Official Synonym Full Names    interleukin 6
 NCBI Official Symbol    IL6 [Similar Products]
 NCBI Official Synonym Symbols   
HGF; HSF; BSF2; IL-6; IFNB2
[Similar Products]
 NCBI Protein Information    interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor
 UniProt Protein Name    Interleukin-6
 UniProt Synonym Protein Names   
B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
 Protein Family    Interleukin
 UniProt Gene Name    IL6 [Similar Products]
 UniProt Synonym Gene Names    IFNB2; IL-6; BSF-2; CDF; IFN-beta-2 [Similar Products]
 UniProt Entry Name    IL6_HUMAN
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 NCBI Summary for IL6    This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]
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 UniProt Comments for IL6    IL6: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ). An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. Belongs to the IL-6 superfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p21

Cellular Component: extracellular space; cytoplasm; extracellular region; interleukin-6 receptor complex; external side of plasma membrane

Molecular Function: protein binding; interleukin-6 receptor binding; growth factor activity; cytokine activity

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of collagen biosynthetic process; negative regulation of cytokine secretion; response to glucocorticoid stimulus; positive regulation of JAK-STAT cascade; positive regulation of leukocyte chemotaxis; glucose homeostasis; bone remodeling; activation of NF-kappaB transcription factor; positive regulation of tyrosine phosphorylation of Stat3 protein; response to caffeine; response to antibiotic; muscle maintenance; monocyte chemotaxis; regulation of cell shape; positive regulation of T-helper 2 cell differentiation; positive regulation of acute inflammatory response; negative regulation of gluconeogenesis; acute-phase response; positive regulation of T cell proliferation; response to electrical stimulus; cell growth; defense response to virus; neurite development; response to drug; platelet activation; positive regulation of protein import into nucleus, translocation; positive regulation of interleukin-6 production; defense response to protozoan; response to amino acid stimulus; negative regulation of fat cell differentiation; positive regulation of chemokine production; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; response to heat; cell redox homeostasis; positive regulation of B cell activation; neutrophil apoptosis; negative regulation of protein kinase activity; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; response to calcium ion; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of muscle development; positive regulation of translation; positive regulation of smooth muscle cell proliferation; negative regulation of hormone secretion; neutrophil mediated immunity; regulation of circadian sleep/wake cycle, non-REM sleep; negative regulation of caspase activity; defense response to Gram-negative bacterium; response to insulin stimulus; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; response to peptidoglycan; positive regulation of cell proliferation; hepatic immune response; inflammatory response; negative regulation of chemokine biosynthetic process; aging; response to nutrient levels; cytokine and chemokine mediated signaling pathway; positive regulation of immunoglobulin secretion; endocrine pancreas development; positive regulation of peptidyl-serine phosphorylation; regulation of angiogenesis; humoral immune response; positive regulation of osteoblast differentiation; positive regulation of protein kinase B signaling cascade; response to cold; positive regulation of neuron differentiation; positive regulation of DNA replication; positive regulation of transmission of nerve impulse

Disease: Rheumatoid Arthritis, Systemic Juvenile; Arteriovenous Malformations Of The Brain; Kaposi Sarcoma, Susceptibility To; Inflammatory Bowel Disease 1
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 Research Articles on IL6    1. Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL6 antibodyPathways associated with anti-IL6 antibody
 Reference Product  PubMed Publications
 JUN antibody  >579 publications with IL6 and JUN
 STAT3 antibody  >377 publications with IL6 and STAT3
 IL1B antibody  >273 publications with IL6 and IL1B
 IL6R antibody  >115 publications with IL6 and IL6R
 IL17A antibody  >114 publications with IL6 and IL17A
 JAK2 antibody  >63 publications with IL6 and JAK2
 STAT1 antibody  >61 publications with IL6 and STAT1
 SOCS3 antibody  >54 publications with IL6 and SOCS3
 IL6ST antibody  >46 publications with IL6 and IL6ST
 FOS antibody  >42 publications with IL6 and FOS
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
Diseases associated with anti-IL6 antibodyOrgans/Tissues associated with anti-IL6 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2321 publications with IL6 and Inflammation
 Necrosis Antibodies  >1686 publications with IL6 and Necrosis
 Autoimmune Diseases Antibodies  >441 publications with IL6 and Autoimmune Diseases
 Skin Diseases Antibodies  >285 publications with IL6 and Skin Diseases
 Obesity Antibodies  >282 publications with IL6 and Obesity
 Arthritis, Rheumatoid Antibodies  >262 publications with IL6 and Arthritis, Rheumatoid
 Atherosclerosis Antibodies  >239 publications with IL6 and Atherosclerosis
 Myocardial Ischemia Antibodies  >225 publications with IL6 and Myocardial Ischemia
 Ischemia Antibodies  >117 publications with IL6 and Ischemia
 Diabetes Mellitus, Type 2 Antibodies  >108 publications with IL6 and Diabetes Mellitus, Type 2
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2967 publications with IL6 and Blood
 Vascular Antibodies  >655 publications with IL6 and Vascular
 Bone Antibodies  >406 publications with IL6 and Bone
 Lung Antibodies  >390 publications with IL6 and Lung
 Brain Antibodies  >366 publications with IL6 and Brain
 Muscle Antibodies  >292 publications with IL6 and Muscle
 Kidney Antibodies  >263 publications with IL6 and Kidney
 Connective Tissue Antibodies  >199 publications with IL6 and Connective Tissue
 Skin Antibodies  >181 publications with IL6 and Skin
 Eye Antibodies  >121 publications with IL6 and Eye
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