NP_001107654.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
interleukin-1 receptor-associated kinase 4 isoform a
NCBI Official Synonym Full Names
interleukin-1 receptor-associated kinase 4
NCBI Protein Information
interleukin-1 receptor-associated kinase 4; IRAK-4; renal carcinoma antigen NY-REN-64
UniProt Protein Name
Interleukin-1 receptor associated kinase-4
UniProt Entry Name
Q69FE3_HUMAN
NCBI Summary for IRAK4 (pT345)
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq]
UniProt Comments for IRAK4 (pT345)
IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.
Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: extracellular space; cytoplasm; plasma membrane; endosome membrane; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; cytokine production; protein amino acid phosphorylation; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; JNK cascade; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
Product References and Citations for anti-IRAK4 (pT345) antibody
Li S et al (2002) IRAK-4, A novel member of the IRAK family with the properties of an IRAK-kinase. PNAS 99 (8): 5567-5572.
Research Articles on IRAK4 (pT345)
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Products associated with anti-IRAK4 (pT345) antibody
Pathways associated with anti-IRAK4 (pT345) antibody
Diseases associated with anti-IRAK4 (pT345) antibody
Organs/Tissues associated with anti-IRAK4 (pT345) antibody
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