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anti-IRAK4 (pT345) antibody :: Mouse IRAK4 (pT345) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS462225
Testing Data
Unit / Price
0.1 mg  /  $275 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRAK4 (pT345) (IRAK4 (pT345)), Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse anti Phospho-IRAK-4 (pThr345)

 Product Synonym Names    Ms anti-Phospho-IRAK4 (pT345); Interleukin-1 receptor-associated kinase 4; IRAK-4; IPD1; REN64; NY-REN-64
 Product Gene Name   

anti-IRAK4 (pT345) antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (44152747..44183346). Location: 12q12
 3D Structure    ModBase 3D Structure for Q69FE3
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    A8A8
 Host    Mouse
 Species Reactivity    Human, Mouse, Bovine, Canine
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 Specificity    This antibody recognizes IRAK-4 (pT345) with a phosphorylated site at Threonine 345. It does not crossreact with non-phosphospecific peptide.
 Purity/Purification    The Mouse IgG is purified by Isotyping-specific Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH 7.2) containing antibody stabilizer
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 Antigen Preparation    A synthetic peptide surrounding to the epitope -VMTSR- with a phosphorylation site at Thr345 of human IRAK-4 protein. This sequence is identical among human, mouse, bovine and dog.
 Positive Control    Jurkat Cell lysate
 Cellular Location    Cytoplasmic
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C -8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-IRAK4 (pT345) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IRAK4 (pT345) antibody

   IRAK (IL-1 associated serine/threonine kinase) is a critical regulator of Interleukin-1 (IL-1) induced activation of the NFkappaB pathway. IL-1 stimulation leads to the recruitment of interleukin-1 receptor-associated kinase (IRAK) to the IL-1 receptor, where IRAK is phosphorylated, ubiquitinated, and eventually degraded. There are four members (IRAK1, IRAK2, IRAK3/IRAK-M and IRAK4). IRAK-4, recently found another IRAK family member necessary for the IL-1 pathway, is able to phosphorylate IRAK in vitro suggests that IRAK-4 might be the IRAK kinase. IRAK4 is required for the efficient recruitment of IRAK to the IL-1 receptor complex.
 Applications Tested/Suitable for anti-IRAK4 (pT345) antibody   

ELISA, Western Blot, Immunohistochemistry
Optimal dilutions should be determined by researchers for the specific applications.

 Application Notes for anti-IRAK4 (pT345) antibody    Western Blot:0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 2-5 ug/ml
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 Testing Data of anti-IRAK4 (pT345) antibody    anti-IRAK4 (pT345) antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for IRAK4 (pT345). It may not necessarily be applicable to this product.
 NCBI GI #    166795295
 NCBI GeneID    51135
 NCBI Accession #    NP_001107654.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114182.2 [Other Products]
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 UniProt Primary Accession #    Q69FE3 [Other Products]
 UniProt Related Accession #    Q69FE3; Q7Z6A7; Q7Z6A8; Q9NWZ3 [Other Products]
 Molecular Weight    ~51 kDa
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 NCBI Official Full Name    interleukin-1 receptor-associated kinase 4 isoform a
 NCBI Official Synonym Full Names    interleukin-1 receptor-associated kinase 4
 NCBI Official Symbol    IRAK4 [Similar Products]
 NCBI Official Synonym Symbols   
IPD1; REN64; NY-REN-64
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor-associated kinase 4; IRAK-4; renal carcinoma antigen NY-REN-64
 UniProt Protein Name    Interleukin-1 receptor associated kinase-4
 UniProt Gene Name    IRAK4 [Similar Products]
 UniProt Entry Name    Q69FE3_HUMAN
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 NCBI Summary for IRAK4 (pT345)    This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq]
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 UniProt Comments for IRAK4 (pT345)    IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: extracellular space; cytoplasm; plasma membrane; endosome membrane; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; cytokine production; protein amino acid phosphorylation; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; JNK cascade; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway

Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
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Product References and Citations for anti-IRAK4 (pT345) antibody

   Li S et al (2002) IRAK-4, A novel member of the IRAK family with the properties of an IRAK-kinase. PNAS 99 (8): 5567-5572.
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 Research Articles on IRAK4 (pT345)    1. These results indicate that IL-1beta-induced IL-6 production in A549 cells is mediated by both PI3K and IRAK4 and suggest that involvement of PI3K in the IL-1-induced IL-6 production is cell type specific.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRAK4 (pT345) antibodyPathways associated with anti-IRAK4 (pT345) antibody
 Reference Product  PubMed Publications
 MYD88 antibody  >58 publications with IRAK4 (pT345) and MYD88
 IRAK1 antibody  >37 publications with IRAK4 (pT345) and IRAK1
 TRAF6 antibody  >26 publications with IRAK4 (pT345) and TRAF6
 PELI1 antibody  >4 publications with IRAK4 (pT345) and PELI1
 PELI2 antibody  >1 publications with IRAK4 (pT345) and PELI2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with anti-IRAK4 (pT345) antibodyOrgans/Tissues associated with anti-IRAK4 (pT345) antibody
 Disease Name  Pubmed Publications
 IRAK4 DEFICIENCY Antibodies  >42 publications with IRAK4 (pT345) and IRAK4 DEFICIENCY
 Inflammation Antibodies  >30 publications with IRAK4 (pT345) and Inflammation
 Necrosis Antibodies  >25 publications with IRAK4 (pT345) and Necrosis
 Death Antibodies  >21 publications with IRAK4 (pT345) and Death
 Lymphoma, B-Cell Antibodies  >3 publications with IRAK4 (pT345) and Lymphoma, B-Cell
 Breast Neoplasms Antibodies  >1 publications with IRAK4 (pT345) and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with IRAK4 (pT345) and Cell Transformation, Neoplastic
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1 publications with IRAK4 (pT345) and Encephalomyelitis, Autoimmune, Experimental
 Ovarian Neoplasms Antibodies  >1 publications with IRAK4 (pT345) and Ovarian Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with IRAK4 (pT345) and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >45 publications with IRAK4 (pT345) and Blood
 Bone Antibodies  >10 publications with IRAK4 (pT345) and Bone
 Bone Marrow Antibodies  >9 publications with IRAK4 (pT345) and Bone Marrow
 Vascular Antibodies  >6 publications with IRAK4 (pT345) and Vascular
 Lung Antibodies  >6 publications with IRAK4 (pT345) and Lung
 Muscle Antibodies  >5 publications with IRAK4 (pT345) and Muscle
 Brain Antibodies  >4 publications with IRAK4 (pT345) and Brain
 Liver Antibodies  >4 publications with IRAK4 (pT345) and Liver
 Skin Antibodies  >4 publications with IRAK4 (pT345) and Skin
 Spleen Antibodies  >3 publications with IRAK4 (pT345) and Spleen
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